Nanosizing by wet beads milling is one of the methods to improve the solubility of poorlywater soluble compounds[1,2].Hydrophilic polymers,such as Hydroxypropylcellulose-SSL(HPC),Polyvinylalcohol(PVA),and Polyvinylpyr...Nanosizing by wet beads milling is one of the methods to improve the solubility of poorlywater soluble compounds[1,2].Hydrophilic polymers,such as Hydroxypropylcellulose-SSL(HPC),Polyvinylalcohol(PVA),and Polyvinylpyrrolidone-K30(PVP)etc.are used as dispersion stabilizer to prevent aggregation of nanoparticles.However,there are many compounds that cannot be dispersed by ordinary dispersion stabilizers.In this study,we used Povacoat?as a dispersion stabilizer for several poorly water soluble compounds milled to nanoparticles.The influences of aggregation of the nanoparticles on the dissolution behavior and the oral absorption of the compoundswere studied using formulations with high and low dispersion characters.展开更多
文摘Nanosizing by wet beads milling is one of the methods to improve the solubility of poorlywater soluble compounds[1,2].Hydrophilic polymers,such as Hydroxypropylcellulose-SSL(HPC),Polyvinylalcohol(PVA),and Polyvinylpyrrolidone-K30(PVP)etc.are used as dispersion stabilizer to prevent aggregation of nanoparticles.However,there are many compounds that cannot be dispersed by ordinary dispersion stabilizers.In this study,we used Povacoat?as a dispersion stabilizer for several poorly water soluble compounds milled to nanoparticles.The influences of aggregation of the nanoparticles on the dissolution behavior and the oral absorption of the compoundswere studied using formulations with high and low dispersion characters.
