Eight darmarane-type saponins,named as sanchirhinoside D(1),3β,6 α-20(S)-6,20-bis(β-D-glucopyranosyloxy)-3-hydroxy dammar-24-en-12-one(2),20(R)-ginsenoside Rg3(3),ginsenosides F2(4)and Rd(5),gypenoside XVII(6),gins...Eight darmarane-type saponins,named as sanchirhinoside D(1),3β,6 α-20(S)-6,20-bis(β-D-glucopyranosyloxy)-3-hydroxy dammar-24-en-12-one(2),20(R)-ginsenoside Rg3(3),ginsenosides F2(4)and Rd(5),gypenoside XVII(6),ginsenosides Rb1(7)and ginsenoside V(8)were isolated from the 70%ethanol extract of Panax notoginseng roots by silica gel,octadecyl silane(ODS)column chromatography and HPLC,and identified by chemical and physical methods,especially by spectral analysis.Among them,1 was a new compound and 2 was a new natural product.展开更多
Objective To study the chemical constituents in the dried roots of Panax notoginseng.Methods The constituents were isolated and purified with chromatographic methods.Their structures were elucidated by spectroscopic m...Objective To study the chemical constituents in the dried roots of Panax notoginseng.Methods The constituents were isolated and purified with chromatographic methods.Their structures were elucidated by spectroscopic methods（1D,2D NMR,UV,IR,[α]D,and HRESI-TOF-MS）and chemical analyses.Results Twenty saponins including 20（S）-ginsenoside Rh1（1）,6-O-β-D-（6′-acetyl）-glucopyranosyl-24-ene-dammar-3β,6α,12β,20S-tetraol（2）,ginseno-side Rf（3）,notoginsenoside R2（4）,ginsenoside Rg2（5）,ginsenoside Rg1（6）,notoginsenoside Rt（7）,koryoginsenoside R1（8）,6-O-（β-D-glucopyranosyl）-20-O-（β-D-xylopyranosyl）-3β,6α,12β,20（S）-tetrahydroxy-dammar-24-ene（9）,pseudoginsenoside Rt3（10）,notoginsenoside R1（11）,ginsenoside Re（12）,notoginsenoside N（13）,ginsenoside F1（14）,ginsenoside U（15）,ginsenoside Rk3（16）,3β,12β-dihydroxydammar-（E）-20（22）,24-diene-6-O-β-D-xylopyranosyl-（1→2）-β-D-glucopyranoside（17）,ginsenoside Rh4（18）,pseudoginsenoside Rt5（19）,and vinaginsenoside R22（20）were obtained.Conclusion Compounds 2,19,and 20 are isolated from this species for the first time.The 1H-NMR data of compound 19 and1H-NMR and 13C-NMR data of compound 20 are first reported.Meanwhile,the NMR data ofβ-D-xylopyranosyl group in compound 9 is corrected.展开更多
基金supported by Program for National Natural Science Foundation of China(NSFC81202995)New Century Excellent Talents in University(NCET-10-0958,NCET-12-1069)+1 种基金Applied Basic and Advanced Research Program of Tianjin(10ZCKFSY09300)Important Drug Development Fund,Ministry of Science and Technology of China(2011ZX09307-002-01).
文摘Eight darmarane-type saponins,named as sanchirhinoside D(1),3β,6 α-20(S)-6,20-bis(β-D-glucopyranosyloxy)-3-hydroxy dammar-24-en-12-one(2),20(R)-ginsenoside Rg3(3),ginsenosides F2(4)and Rd(5),gypenoside XVII(6),ginsenosides Rb1(7)and ginsenoside V(8)were isolated from the 70%ethanol extract of Panax notoginseng roots by silica gel,octadecyl silane(ODS)column chromatography and HPLC,and identified by chemical and physical methods,especially by spectral analysis.Among them,1 was a new compound and 2 was a new natural product.
基金Fund: Important Drug Development Fund, Ministry of Science and Technology of China (2012ZX09101201-002)Research Fund for the Doctoral Program of Higher Education of China (20121210110007)
文摘Objective To study the chemical constituents in the dried roots of Panax notoginseng.Methods The constituents were isolated and purified with chromatographic methods.Their structures were elucidated by spectroscopic methods（1D,2D NMR,UV,IR,[α]D,and HRESI-TOF-MS）and chemical analyses.Results Twenty saponins including 20（S）-ginsenoside Rh1（1）,6-O-β-D-（6′-acetyl）-glucopyranosyl-24-ene-dammar-3β,6α,12β,20S-tetraol（2）,ginseno-side Rf（3）,notoginsenoside R2（4）,ginsenoside Rg2（5）,ginsenoside Rg1（6）,notoginsenoside Rt（7）,koryoginsenoside R1（8）,6-O-（β-D-glucopyranosyl）-20-O-（β-D-xylopyranosyl）-3β,6α,12β,20（S）-tetrahydroxy-dammar-24-ene（9）,pseudoginsenoside Rt3（10）,notoginsenoside R1（11）,ginsenoside Re（12）,notoginsenoside N（13）,ginsenoside F1（14）,ginsenoside U（15）,ginsenoside Rk3（16）,3β,12β-dihydroxydammar-（E）-20（22）,24-diene-6-O-β-D-xylopyranosyl-（1→2）-β-D-glucopyranoside（17）,ginsenoside Rh4（18）,pseudoginsenoside Rt5（19）,and vinaginsenoside R22（20）were obtained.Conclusion Compounds 2,19,and 20 are isolated from this species for the first time.The 1H-NMR data of compound 19 and1H-NMR and 13C-NMR data of compound 20 are first reported.Meanwhile,the NMR data ofβ-D-xylopyranosyl group in compound 9 is corrected.
