Denture stomatitis and fungal infection are commonly found in long-time denture wearer. Ionic liquids have been used as plasticizer and also possess antimicrobial activity. In this study, ionic liquid in form of 1-Dec...Denture stomatitis and fungal infection are commonly found in long-time denture wearer. Ionic liquids have been used as plasticizer and also possess antimicrobial activity. In this study, ionic liquid in form of 1-Decyl-3-methy-limidazolium chloride was incorporated into tissue conditioner (GC Soft-liner TM) to improve antifungal activity. Physical and mechanical properties were evaluated. Compliance was carried out using penetration test according to ISO 10139-1. Weight change, water absorption and solubility were determined by weight measurement. Conventional and nystatin-incorporated tissue conditioner served as controls. Results showed that ionic liquid-incorporated tissue conditioner significantly decreased fungal formation, both in material suspension and on material surface. The penetration depth of all groups tended to reduce over time with no significant difference at each time point. After water immersion, ionic liquid- and nystatin-incorporated tissue conditioner gained weight while conventional group showed weight loss. The percentage of water absorption of conventional group was significantly lower than ionic liquid and nystatin group, while the percentage of water solubility of nystatin group was significantly higher than others. Our work indicated that antifungal ionic liquid-incorporated tissue conditioner met the standard criteria in terms of material compliance. However, further studies including dynamic viscoelastic property are needed before clinical trial or application.展开更多
文摘Denture stomatitis and fungal infection are commonly found in long-time denture wearer. Ionic liquids have been used as plasticizer and also possess antimicrobial activity. In this study, ionic liquid in form of 1-Decyl-3-methy-limidazolium chloride was incorporated into tissue conditioner (GC Soft-liner TM) to improve antifungal activity. Physical and mechanical properties were evaluated. Compliance was carried out using penetration test according to ISO 10139-1. Weight change, water absorption and solubility were determined by weight measurement. Conventional and nystatin-incorporated tissue conditioner served as controls. Results showed that ionic liquid-incorporated tissue conditioner significantly decreased fungal formation, both in material suspension and on material surface. The penetration depth of all groups tended to reduce over time with no significant difference at each time point. After water immersion, ionic liquid- and nystatin-incorporated tissue conditioner gained weight while conventional group showed weight loss. The percentage of water absorption of conventional group was significantly lower than ionic liquid and nystatin group, while the percentage of water solubility of nystatin group was significantly higher than others. Our work indicated that antifungal ionic liquid-incorporated tissue conditioner met the standard criteria in terms of material compliance. However, further studies including dynamic viscoelastic property are needed before clinical trial or application.
