PURPOSE: To report the efficacy of electrolysis as a treatment of corneal opac ities in a young patient with the superficial variant of granular corneal dystro phy. DESIGN: Interventional case report. METHODS: An 11-y...PURPOSE: To report the efficacy of electrolysis as a treatment of corneal opac ities in a young patient with the superficial variant of granular corneal dystro phy. DESIGN: Interventional case report. METHODS: An 11-year-old boy presented with subepithelial opacities in both eyes. His visual acuity was 0.2 in the lef t eye; he received corneal electrolysis under topical anesthesia. RESULTS: The e lectrolysis, which required only 5 minutes, resulted in the disappearance of the subepithelial opacities. His visual acuity improved to 0.4 on the next day and was 1.0 eight months later. The corneal curvature and thickness were not altered by the electrolysis. CONCLUSIONS: Corneal electrolysis proved to be an effectiv e treatment for subepithelial opacities, and we recommend electrolysis as an eff ective and simple treatment for young patients with SGCD.展开更多
Background:Atopic dermatitis(AD),a significant problemin Japan,has a major impact on health-related quality of life(QOL).The development of steroid phobia in patients with AD may restrict the therapeutic options avail...Background:Atopic dermatitis(AD),a significant problemin Japan,has a major impact on health-related quality of life(QOL).The development of steroid phobia in patients with AD may restrict the therapeutic options available to these patients.Tacrolimus ointment is a safe and effective nonsteroid treatment for AD.It may be an appropriate alternative for patients with AD and steroid phobia.The aim of this study was to determine the impact of AD on QOL and to investigate the effect of tacrolimus ointment on QOL in patients with steroid phobia.Methods:Firstly,QOL scores were investigated inpatients with AD and steroid phobia using the World Health Organization Quality of Life instrument,WHOQOL-26,and were compared with QOL scores from a previous study in volunteers from Tokyo,Japan.Secondly,patients with steroid phobia received tacrolimus ointment treatment for 12 weeks.Quality of life scores were assessed using WHOQOL-26 at baseline and study end.Results:The overall mean QOL score of 106 patients with AD was significantly lower than that of 708 volunteers(3.1 ±0.5 vs.3.3 ±0.5,P < 0.001).The overall QOL score improved from 2.9 ±0.4 at baseline to 3.3±0.4 following 12 weeks’tacrolimus ointment treatment in 35 patients with AD and steroid phobia(P < 0.001).Conclusions:Atopic dermatitis significantly lowers QOL.Tacrolimus ointmentis associated with a significant improvement in QOL inpatients with steroid phobia,indicating that it is an effective alternative to topical corticosteroids in these patients.展开更多
文摘PURPOSE: To report the efficacy of electrolysis as a treatment of corneal opac ities in a young patient with the superficial variant of granular corneal dystro phy. DESIGN: Interventional case report. METHODS: An 11-year-old boy presented with subepithelial opacities in both eyes. His visual acuity was 0.2 in the lef t eye; he received corneal electrolysis under topical anesthesia. RESULTS: The e lectrolysis, which required only 5 minutes, resulted in the disappearance of the subepithelial opacities. His visual acuity improved to 0.4 on the next day and was 1.0 eight months later. The corneal curvature and thickness were not altered by the electrolysis. CONCLUSIONS: Corneal electrolysis proved to be an effectiv e treatment for subepithelial opacities, and we recommend electrolysis as an eff ective and simple treatment for young patients with SGCD.
文摘Background:Atopic dermatitis(AD),a significant problemin Japan,has a major impact on health-related quality of life(QOL).The development of steroid phobia in patients with AD may restrict the therapeutic options available to these patients.Tacrolimus ointment is a safe and effective nonsteroid treatment for AD.It may be an appropriate alternative for patients with AD and steroid phobia.The aim of this study was to determine the impact of AD on QOL and to investigate the effect of tacrolimus ointment on QOL in patients with steroid phobia.Methods:Firstly,QOL scores were investigated inpatients with AD and steroid phobia using the World Health Organization Quality of Life instrument,WHOQOL-26,and were compared with QOL scores from a previous study in volunteers from Tokyo,Japan.Secondly,patients with steroid phobia received tacrolimus ointment treatment for 12 weeks.Quality of life scores were assessed using WHOQOL-26 at baseline and study end.Results:The overall mean QOL score of 106 patients with AD was significantly lower than that of 708 volunteers(3.1 ±0.5 vs.3.3 ±0.5,P < 0.001).The overall QOL score improved from 2.9 ±0.4 at baseline to 3.3±0.4 following 12 weeks’tacrolimus ointment treatment in 35 patients with AD and steroid phobia(P < 0.001).Conclusions:Atopic dermatitis significantly lowers QOL.Tacrolimus ointmentis associated with a significant improvement in QOL inpatients with steroid phobia,indicating that it is an effective alternative to topical corticosteroids in these patients.
