Background. Behc.et’s disease (BD) is a multisystemic disease of unknown etio logy characterized by chronic relapsing oral-genital ulcers and uveitis. Some a bnormalities in lipoprotein metabolism have been described...Background. Behc.et’s disease (BD) is a multisystemic disease of unknown etio logy characterized by chronic relapsing oral-genital ulcers and uveitis. Some a bnormalities in lipoprotein metabolism have been described in patients with BD. Methods. In this study, apolipoprotein E (apo E) polymorphism and lipoprotein ch olesterol concentrations in 30 patients with BD were compared with those of 27 c ontrol subjects. Results. Both patients and controls were found to be normolipid emic. Patients with BD had significantly higher concentrations of high-density lipoprotein (HDL) cholesterol than those of controls (P < .0.05); however, there was no difference in serum triglyceride, low-densitylipoprotein(LDL)and very l ow-density lipoprotein (VLDL) cholesterol concentrations. The distribution of a po E genotypes and alleles was the same in both groups. There were slight differ ences in allele frequency between the groups, but this was not statistically sig nificant. Conclusions. The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles.展开更多
Background. Patients frequently request the removal of benign, papular and dome-shaped nevi for cosmetic or functional reasons. Total excision is probably the most widely used method of removal. Aim. To introduce the ...Background. Patients frequently request the removal of benign, papular and dome-shaped nevi for cosmetic or functional reasons. Total excision is probably the most widely used method of removal. Aim. To introduce the round excision technique for the treatment of benign, papular and dome-shaped nevi on the face. Methods. In a prospective study, 36 benign, papular or dome-shaped nevi of all types were removed by the round excision technique. The lesions were circumscribed with a number 15 scalpel blade, 2 mm beyond the limits, with incision to the full depth of the dermis, and removed by cutting horizontally at the maximum depth of the circular incision. Histologic examinations were performed for all specimens. Results. Complete removal of nevi was achieved in all patients with excellent or good cosmetic results. Of the 36 nevi, 24 were intradermal and 12 were compound nevi. Dog-ear formation was observed in only one patient. Conclusion. Round excision may be a better alternative to conventional fusiformor shaveexcision of benign, dome-shaped or papular nevi of the face.展开更多
文摘Background. Behc.et’s disease (BD) is a multisystemic disease of unknown etio logy characterized by chronic relapsing oral-genital ulcers and uveitis. Some a bnormalities in lipoprotein metabolism have been described in patients with BD. Methods. In this study, apolipoprotein E (apo E) polymorphism and lipoprotein ch olesterol concentrations in 30 patients with BD were compared with those of 27 c ontrol subjects. Results. Both patients and controls were found to be normolipid emic. Patients with BD had significantly higher concentrations of high-density lipoprotein (HDL) cholesterol than those of controls (P < .0.05); however, there was no difference in serum triglyceride, low-densitylipoprotein(LDL)and very l ow-density lipoprotein (VLDL) cholesterol concentrations. The distribution of a po E genotypes and alleles was the same in both groups. There were slight differ ences in allele frequency between the groups, but this was not statistically sig nificant. Conclusions. The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles.
文摘Background. Patients frequently request the removal of benign, papular and dome-shaped nevi for cosmetic or functional reasons. Total excision is probably the most widely used method of removal. Aim. To introduce the round excision technique for the treatment of benign, papular and dome-shaped nevi on the face. Methods. In a prospective study, 36 benign, papular or dome-shaped nevi of all types were removed by the round excision technique. The lesions were circumscribed with a number 15 scalpel blade, 2 mm beyond the limits, with incision to the full depth of the dermis, and removed by cutting horizontally at the maximum depth of the circular incision. Histologic examinations were performed for all specimens. Results. Complete removal of nevi was achieved in all patients with excellent or good cosmetic results. Of the 36 nevi, 24 were intradermal and 12 were compound nevi. Dog-ear formation was observed in only one patient. Conclusion. Round excision may be a better alternative to conventional fusiformor shaveexcision of benign, dome-shaped or papular nevi of the face.
