The purpose of this study was to evaluate the diagnostic value of an interleukin- 6 (IL- 6) bedside test of vaginal secretions for neonatal infection in cases of preterm premature rupture of membranes. This prospectiv...The purpose of this study was to evaluate the diagnostic value of an interleukin- 6 (IL- 6) bedside test of vaginal secretions for neonatal infection in cases of preterm premature rupture of membranes. This prospective clinical study included 73 patients. Interleukin- 6 protein in vaginal secretions was determined with an immunochromatographic bedside test in < 20 minutes. Elevated C- reactive protein level (>20 mg/dL; odds ratio, 5.1; 95% CI, 0.9- 28.6) and positive interleukin- 6 level (odds ratio, 4.6; 95% CI, 1.2- 18.4) were both associated with neonatal infection. After adjustment, only interleukin- 6 remained associated with neonatal infection (odds ratio, 4.5; 95% CI, 1.1- 18.5). The sensitivity of interleukin- 6 for the prediction of neonatal infection was 79% (95% CI, 65- 92); its specificity was 56% (95% CI, 42- 70); its positive predictive value was 30% (95% CI, 12- 47), and its negative predictive value was 92% (95% CI, 84- 99). Interleukin- 6 protein determination by this new immunochromatographic test is a noninvasive prenatal vaginal marker of neonatal infection.展开更多
文摘The purpose of this study was to evaluate the diagnostic value of an interleukin- 6 (IL- 6) bedside test of vaginal secretions for neonatal infection in cases of preterm premature rupture of membranes. This prospective clinical study included 73 patients. Interleukin- 6 protein in vaginal secretions was determined with an immunochromatographic bedside test in < 20 minutes. Elevated C- reactive protein level (>20 mg/dL; odds ratio, 5.1; 95% CI, 0.9- 28.6) and positive interleukin- 6 level (odds ratio, 4.6; 95% CI, 1.2- 18.4) were both associated with neonatal infection. After adjustment, only interleukin- 6 remained associated with neonatal infection (odds ratio, 4.5; 95% CI, 1.1- 18.5). The sensitivity of interleukin- 6 for the prediction of neonatal infection was 79% (95% CI, 65- 92); its specificity was 56% (95% CI, 42- 70); its positive predictive value was 30% (95% CI, 12- 47), and its negative predictive value was 92% (95% CI, 84- 99). Interleukin- 6 protein determination by this new immunochromatographic test is a noninvasive prenatal vaginal marker of neonatal infection.
