Bone marrow cells are capable of differentiation into liver cells.Therefore,transplantation of bone marrow cells has considerable potential as a future therapy for regeneration of damaged liver tissue.Autologous bone ...Bone marrow cells are capable of differentiation into liver cells.Therefore,transplantation of bone marrow cells has considerable potential as a future therapy for regeneration of damaged liver tissue.Autologous bone marrow infusion therapy has been applied to patients with liver cirrhosis,and improvement of liver function parameters has been demonstrated.In this review,we summarize clinical trials of regenerative therapy using bone marrow cells for advanced liver diseases including cirrhosis,as well as topics pertaining to basic in vitro or in vivo approaches in order to outline the essentials of this novel treatment modality.展开更多
AIM: To clarify the characteristics of metabolite profiles in virus-related hepatocellular carcinoma (HCC) patients using serum metabolome analysis.METHODS: The serum levels of low-molecular-weight metabolites in 68 p...AIM: To clarify the characteristics of metabolite profiles in virus-related hepatocellular carcinoma (HCC) patients using serum metabolome analysis.METHODS: The serum levels of low-molecular-weight metabolites in 68 patients with HCC were quantified using capillary electrophoresis chromatography and mass spectrometry. Thirty and 38 of the patients suffered from hepatitis B virus-related HCC (HCC-B) and hepatitis C virus-related HCC (HCC-C), respectively.RESULTS: The main metabolites characteristic of HCC were those associated with glutathione metabolism, notably 13 γ-glutamyl peptides, which are by-products of glutathione induction. Two major profiles, i.e., concentration patterns, of metabolites were identified in HCC patients, and these were classified into two groups: an HCC-B group and an HCC-C group including some of the HCC-B cases. The receiver operating characteristic curve for the multiple logistic regression model discriminating HCC-B from HCC-C incorporating the concentrations of glutamic acid, methionine and γ-glutamyl-glycine-glycine showed a highly significant area under the curve value of 0.94 (95%CI: 0.89-1.0, P < 0.0001).CONCLUSION: The serum levels of γ-glutamyl peptides, as well as their concentration patterns, contribute to the development of potential biomarkers for virus-related HCC. The difference in metabolite profiles between HCC-B and HCC-C may reflect the respective metabolic reactions that underlie the different pathogeneses of these two types of HCC.展开更多
文摘Bone marrow cells are capable of differentiation into liver cells.Therefore,transplantation of bone marrow cells has considerable potential as a future therapy for regeneration of damaged liver tissue.Autologous bone marrow infusion therapy has been applied to patients with liver cirrhosis,and improvement of liver function parameters has been demonstrated.In this review,we summarize clinical trials of regenerative therapy using bone marrow cells for advanced liver diseases including cirrhosis,as well as topics pertaining to basic in vitro or in vivo approaches in order to outline the essentials of this novel treatment modality.
基金Supported by the Japan Agency for Medical Research and DevelopmentYamagata Prefectural Government and City of Tsuruoka
文摘AIM: To clarify the characteristics of metabolite profiles in virus-related hepatocellular carcinoma (HCC) patients using serum metabolome analysis.METHODS: The serum levels of low-molecular-weight metabolites in 68 patients with HCC were quantified using capillary electrophoresis chromatography and mass spectrometry. Thirty and 38 of the patients suffered from hepatitis B virus-related HCC (HCC-B) and hepatitis C virus-related HCC (HCC-C), respectively.RESULTS: The main metabolites characteristic of HCC were those associated with glutathione metabolism, notably 13 γ-glutamyl peptides, which are by-products of glutathione induction. Two major profiles, i.e., concentration patterns, of metabolites were identified in HCC patients, and these were classified into two groups: an HCC-B group and an HCC-C group including some of the HCC-B cases. The receiver operating characteristic curve for the multiple logistic regression model discriminating HCC-B from HCC-C incorporating the concentrations of glutamic acid, methionine and γ-glutamyl-glycine-glycine showed a highly significant area under the curve value of 0.94 (95%CI: 0.89-1.0, P < 0.0001).CONCLUSION: The serum levels of γ-glutamyl peptides, as well as their concentration patterns, contribute to the development of potential biomarkers for virus-related HCC. The difference in metabolite profiles between HCC-B and HCC-C may reflect the respective metabolic reactions that underlie the different pathogeneses of these two types of HCC.
