Background:Once a global financial crisis breaks out,the interdependence between different financial markets suddenly increases and leads to a significant contagion.Methods:With 39 countries used as samples,this paper...Background:Once a global financial crisis breaks out,the interdependence between different financial markets suddenly increases and leads to a significant contagion.Methods:With 39 countries used as samples,this paper analyzes the interdependence between the stock market and the government bond market during the crisis periods.Results:It proves that the investor focuses more on the safety of their portfolio so there is neither a flight from quality nor a positive spillover during a crisis period.When one market is safer than the other market in the same country,a flight to quality occurs between the two markets;however,when the two markets in one country are both risky,negative spillover appears between these two markets.Conclusions:This means a flight to quality from the stock market to the short-term government bond will occur more frequently than will occur from the stock market to the long-term government bond markets.In addition,a flight to quality always emerges in developed markets,while negative spillovers take place in emerging markets and in the PIIGS countries(Portugal,Italy,Ireland,Greece,and Spain,referred to hereon as“PIIGS”)in the European Debt Crisis.展开更多
Hydrogen peroxide(H2O2)plays a significant role in regulating a variety of biological processes.Dysregulation of H2O2 can lead to various diseases.Although numerous fluorescent imaging probes for H2O2 have been report...Hydrogen peroxide(H2O2)plays a significant role in regulating a variety of biological processes.Dysregulation of H2O2 can lead to various diseases.Although numerous fluorescent imaging probes for H2O2 have been reported,the development of H2O2 ratiometric fluorescent probe with large Stokes shift remains rather limited.Such probes have shown distinct advantages,such as minimized interference from environment and improved signal-to noise ratio.In this work,we reported a new pyrene-based compound Py-VPB as H2O2 fluorescent probe in vitro.The probe demonstrated ratiometric detection behavior,large Stokes shift and large emission shift.In addition,the probe showed high sensitivity and selectivity towards H2O2 in vitro.Based on these excellent properties,we successfully applied Py-VPB to the visualization of exogenous and endogenous H2O2 in living cells.Cell imaging study also showed that our probe was localized in the mitochondria.We envision that the probe can provide a useful tool for unmasking the biological roles of mitochondrial H2O2 in living systems.展开更多
Automated optical inspection(AOI)is a significant process in printed circuit board assembly(PCBA)production lines which aims to detect tiny defects in PCBAs.Existing AOI equipment has several deficiencies including lo...Automated optical inspection(AOI)is a significant process in printed circuit board assembly(PCBA)production lines which aims to detect tiny defects in PCBAs.Existing AOI equipment has several deficiencies including low throughput,large computation cost,high latency,and poor flexibility,which limits the efficiency of online PCBA inspection.In this paper,a novel PCBA defect detection method based on a lightweight deep convolution neural network is proposed.In this method,the semantic segmentation model is combined with a rule-based defect recognition algorithm to build up a defect detection frame-work.To improve the performance of the model,extensive real PCBA images are collected from production lines as datasets.Some optimization methods have been applied in the model according to production demand and enable integration in lightweight computing devices.Experiment results show that the production line using our method realizes a throughput more than three times higher than traditional methods.Our method can be integrated into a lightweight inference system and pro-mote the flexibility of AOI.The proposed method builds up a general paradigm and excellent example for model design and optimization oriented towards industrial requirements.展开更多
To the Editor:Despite of the rapid increase of donation after cardiac death (DCD) in China, the shortage of organs continues to be a major problem. Every organ procured is so valuable that it should never be discar...To the Editor:Despite of the rapid increase of donation after cardiac death (DCD) in China, the shortage of organs continues to be a major problem. Every organ procured is so valuable that it should never be discarded easily, especially a liver that could save a patient's life in an emergency. This leads to the use of grafts from donors with unrecognized Here and unusual diseases, including schistosomiasis. we reported a case of orthotopic liver transplantation (OLT) from a donor with Schistosorna japonicurn to a patient with end-stage cirrhosis due to HBV infection.展开更多
The orbital angular momentum(OAM)of light has been implemented as an information carrier in OAM holography.Holographic information can be multiplexed in theoretical unbounded OAM channels,promoting the applications of...The orbital angular momentum(OAM)of light has been implemented as an information carrier in OAM holography.Holographic information can be multiplexed in theoretical unbounded OAM channels,promoting the applications of optically addressable dynamic display and high-security optical encryption.However,the frame-rate of the dynamic extraction of the information reconstruction process in OAM holography is physically determined by the switching speed of the incident OAM states,which is currently below 30 Hz limited by refreshing rate of the phase-modulation spatial light modulator(SLM).Here,based on a cross convolution with the spatial frequency of the OAM-multiplexing hologram,the spatial frequencies of an elaborately-designed amplitude distribution,namely amplitude decoding key,has been adopted for the extraction of three-dimensional holographic information encoded in a specific OAM information channel.We experimentally demonstrated a dynamic extraction frame rate of 100 Hz from an OAM multiplexing hologram with 10 information channels indicated by individual OAM values from-50 to 50.The new concept of cross convolution theorem can even provide the potential of parallel reproduction and distribution of information encoded in many OAM channels at various positions which boosts the capacity of information processing far beyond the traditional decoding methods.Thus,our results provide a holographic paradigm for high-speed 3D information processing,paving an unprecedented way to achieve the high-capacity short-range optical communication system.展开更多
Tree diversity has long been considered a key driver of insect herbivory in forest ecosystems.However,studies have given contradictory results:increased tree diversity can have positive,negative or neutral effects on ...Tree diversity has long been considered a key driver of insect herbivory in forest ecosystems.However,studies have given contradictory results:increased tree diversity can have positive,negative or neutral effects on insect herbivory.Since many issues can complicate the tree-herbivore interactions,the descriptor‘tree diversity’per se actually has only limited explanatory power for insect herbivory.Particularly,in addition to the direct bottom-up effects on insect herbivores,tree diversity may have stronger indirect top-down effects via natural enemies of insect herbivores.However,most research has addressed only direct bottom-up impacts.In fact,insect herbivory is the result of complex interactions(food webs)among all the species in a community.Although it is hard to integrate all functionally important species and dynamic information into food webs,the effects of tree diversity on insect herbivory are highly dependent on the dominant species at different trophic levels.It is important and practical to simultaneously consider the characteristics of main trees,herbivores,and natural enemies when attempting to predict the overall effects of forest tree diversity on insect herbivory.In order to ensure comparability between studies,it is necessary to classify them according to the descriptors of insect herbivory and tree diversity,and to compare results within each category.These measures might enhance our understanding of the mechanisms by which tree diversity drives insect herbivory and,in turn,help to develop sustainable pest management strategies for forests.展开更多
To explore the effect of non-uniform polarization on orbital angular momentum(OAM) in anisotropic medium, in this work investigated are the evolution of the spiral spectra and OAM densities of non-uniformly polarized ...To explore the effect of non-uniform polarization on orbital angular momentum(OAM) in anisotropic medium, in this work investigated are the evolution of the spiral spectra and OAM densities of non-uniformly polarized vortex(NUPV)beams in uniaxial crystals propagating orthogonal to the optical axis, and also the case of uniformly polarized vortex(UPV)beams with left-handed elliptical polarization. In the input plane, the NUPV beams present their spiral spectra of m-mode concentrated at m = l ± 1 modes rather than m = l mode, and reveal the relation among topological charge l, mode of spiral spectra m and the power weight value Rmexpressed by l=∑^(∞)_(m)=-∞Rm. is still satisfied for UPV beams in uniaxially anisotropic crystals, whereas for NUPV beams their relations are no longer valid owing to non-uniform polarization. Furthermore, the analysis indicates that the asymmetrical distribution of power weight of spiral spectra and the non-zero value in the sum of longitudinal OAM densities originate from the initial non-uniform polarization and anisotropy in uniaxial crystals rather than topological charges. In addition, the relation between spiral spectrum and longitudinal OAM density is numerically discussed. This work may provide an avenue for OAM-based communications,optical metrology, and imaging by varying the initial non-uniform polarization.展开更多
Black phosphorus(BP)nano-materials,especially BP quantum dots(BPQDs),performs outstanding photothermal antitumor effects,excellent biocompatibility and biodegradability.However,there are several challenges to overcome...Black phosphorus(BP)nano-materials,especially BP quantum dots(BPQDs),performs outstanding photothermal antitumor effects,excellent biocompatibility and biodegradability.However,there are several challenges to overcome before offering real benefits,such as poor stability,poor dispersibility as well as difficulty in tailoring other functions.Here,a“three-in-one”mitochondria-targeted BP nano-platform,called as BPQD-PEG-TPP,was designed.In this nano-platform,BPQDs were covalently grafted with a heterobifunctional PEG,in which one end was an aryl diazo group capable of reacting with BPQDs to form a covalent bond and the other end was a mitochondria-targeted triphenylphosphine(TPP)group.In addition to its excellent near-infrared photothermal properties,BPQD-PEG-TPP had much enhanced stability and dispersibility under physiological conditions,efficient mitochondria targeting and promoted ROS production through a photothermal effect.Both in vitro and in vivo experiments demonstrated that BPQD-PEG-TPP performed much superior photothermal cytotoxicity than BPQDs and BPQD-PEG as the mitochondria targeted PTT.Thus this“three-in-one”nanoplatform fabricated through polymer grafting,with excellent stability,dispersibility and negligible side effects,might be a promising strategy for mitochondria-targeted photothermal cancer therapy.展开更多
We employ a Hall-effect magnetic sensor array to accurately track the trajectory of a single magnetic sphere,referred to as the“intruder,”within a three-dimensional vibro-fluidized granular bed to unravel the underl...We employ a Hall-effect magnetic sensor array to accurately track the trajectory of a single magnetic sphere,referred to as the“intruder,”within a three-dimensional vibro-fluidized granular bed to unravel the underlying physical mechanism governing the motion of the intruder.Within the acceleration range of 3.5 g≥Γ≥1.5 g,we find that,regardless of the intruder's initial position,it consistently reaches the same equilibrium depth when the vibration acceleration(Γ)and frequency(ω)are fixed.ForΓ≤2.5 g,the equilibrium position lies on the surface of the granular bed,while forΓ>2.5 g,it shifts below the surface.Additionally,intruders with different densities exhibit varying equilibrium depths,with higher density resulting in a deeper equilibrium position.To understand the mechanism behind the intruder's upward or downward motion,we measure its rising or sinking velocities under different vibration parameters.Our findings demonstrate that the rising velocity of the intruder,under varying vibration accelerations(Γ)and frequencies(ω),can be collapsed using the ratioΓ/ω,while the sinking velocity remains unaffected by the vibration strength.This confirms that the upward motion of the larger sphere,associated with the Brazil nut effect,primarily arises from the void-filling mechanism of the bed particles.Furthermore,our experiments reveal that the presence of convection within the bed particles has minimal impact on the motion of the intruder.展开更多
Fiber reinforced polymer(FRP)has been used in the construction industry because of its advantages such as high strength,light weight,corrosion resistance,low density and high elasticity.This paper presents a review of...Fiber reinforced polymer(FRP)has been used in the construction industry because of its advantages such as high strength,light weight,corrosion resistance,low density and high elasticity.This paper presents a review of bonding techniques adopted to strengthen timber beams using FRP to achieve larger spans.Different methods of bonding between FRP and timber beams have been summarized with a focus on the influencing factors and their effects as well as relevant bond-slip models proposed for fundamental understanding.Experimental investigations to evaluate the flexural performance of timber beams strengthened by FRP bars,sheets and wraps have also been critically reviewed to identify key influencing parameters.Limited research available on the shear performance of FRP reinforced timber beams have been analyzed to determine the influencing factors of the shear performance in timber-FRP beams.The paper finally presents an overall summary of the current-state-of-the-art and proposes some future research directions in the field.展开更多
To the Editor:Graft versus host disease(GVHD)occurs when the immunocompetent cells from the donor mount an immune response against the tissues of the host[1].It is commonly seen in the patients who received hematopoie...To the Editor:Graft versus host disease(GVHD)occurs when the immunocompetent cells from the donor mount an immune response against the tissues of the host[1].It is commonly seen in the patients who received hematopoietic stem cell transplantation(HSCT).GVHD is a rare but lethal complication in orthotopic liver展开更多
基金This paper is funded by China Postdoctoral Science Foundation(2014M550985)National Science Foundation of China(71532013,71528001).
文摘Background:Once a global financial crisis breaks out,the interdependence between different financial markets suddenly increases and leads to a significant contagion.Methods:With 39 countries used as samples,this paper analyzes the interdependence between the stock market and the government bond market during the crisis periods.Results:It proves that the investor focuses more on the safety of their portfolio so there is neither a flight from quality nor a positive spillover during a crisis period.When one market is safer than the other market in the same country,a flight to quality occurs between the two markets;however,when the two markets in one country are both risky,negative spillover appears between these two markets.Conclusions:This means a flight to quality from the stock market to the short-term government bond will occur more frequently than will occur from the stock market to the long-term government bond markets.In addition,a flight to quality always emerges in developed markets,while negative spillovers take place in emerging markets and in the PIIGS countries(Portugal,Italy,Ireland,Greece,and Spain,referred to hereon as“PIIGS”)in the European Debt Crisis.
基金This work was supported by the Science Technology and Innovation Committee of Shenzhen Municipality(JCYJ20180507181654823)the National Natural Science Foundation of China(21778044)and Sichuan Science and Technology Program(2018JY0360).
文摘Hydrogen peroxide(H2O2)plays a significant role in regulating a variety of biological processes.Dysregulation of H2O2 can lead to various diseases.Although numerous fluorescent imaging probes for H2O2 have been reported,the development of H2O2 ratiometric fluorescent probe with large Stokes shift remains rather limited.Such probes have shown distinct advantages,such as minimized interference from environment and improved signal-to noise ratio.In this work,we reported a new pyrene-based compound Py-VPB as H2O2 fluorescent probe in vitro.The probe demonstrated ratiometric detection behavior,large Stokes shift and large emission shift.In addition,the probe showed high sensitivity and selectivity towards H2O2 in vitro.Based on these excellent properties,we successfully applied Py-VPB to the visualization of exogenous and endogenous H2O2 in living cells.Cell imaging study also showed that our probe was localized in the mitochondria.We envision that the probe can provide a useful tool for unmasking the biological roles of mitochondrial H2O2 in living systems.
基金supported in part by the IoT Intelligent Microsystem Center of Tsinghua University-China Mobile Joint Research Institute.
文摘Automated optical inspection(AOI)is a significant process in printed circuit board assembly(PCBA)production lines which aims to detect tiny defects in PCBAs.Existing AOI equipment has several deficiencies including low throughput,large computation cost,high latency,and poor flexibility,which limits the efficiency of online PCBA inspection.In this paper,a novel PCBA defect detection method based on a lightweight deep convolution neural network is proposed.In this method,the semantic segmentation model is combined with a rule-based defect recognition algorithm to build up a defect detection frame-work.To improve the performance of the model,extensive real PCBA images are collected from production lines as datasets.Some optimization methods have been applied in the model according to production demand and enable integration in lightweight computing devices.Experiment results show that the production line using our method realizes a throughput more than three times higher than traditional methods.Our method can be integrated into a lightweight inference system and pro-mote the flexibility of AOI.The proposed method builds up a general paradigm and excellent example for model design and optimization oriented towards industrial requirements.
基金supported by a grant from the Wu Jieping Medical Foundation(320.6750.15070)
文摘To the Editor:Despite of the rapid increase of donation after cardiac death (DCD) in China, the shortage of organs continues to be a major problem. Every organ procured is so valuable that it should never be discarded easily, especially a liver that could save a patient's life in an emergency. This leads to the use of grafts from donors with unrecognized Here and unusual diseases, including schistosomiasis. we reported a case of orthotopic liver transplantation (OLT) from a donor with Schistosorna japonicurn to a patient with end-stage cirrhosis due to HBV infection.
文摘The orbital angular momentum(OAM)of light has been implemented as an information carrier in OAM holography.Holographic information can be multiplexed in theoretical unbounded OAM channels,promoting the applications of optically addressable dynamic display and high-security optical encryption.However,the frame-rate of the dynamic extraction of the information reconstruction process in OAM holography is physically determined by the switching speed of the incident OAM states,which is currently below 30 Hz limited by refreshing rate of the phase-modulation spatial light modulator(SLM).Here,based on a cross convolution with the spatial frequency of the OAM-multiplexing hologram,the spatial frequencies of an elaborately-designed amplitude distribution,namely amplitude decoding key,has been adopted for the extraction of three-dimensional holographic information encoded in a specific OAM information channel.We experimentally demonstrated a dynamic extraction frame rate of 100 Hz from an OAM multiplexing hologram with 10 information channels indicated by individual OAM values from-50 to 50.The new concept of cross convolution theorem can even provide the potential of parallel reproduction and distribution of information encoded in many OAM channels at various positions which boosts the capacity of information processing far beyond the traditional decoding methods.Thus,our results provide a holographic paradigm for high-speed 3D information processing,paving an unprecedented way to achieve the high-capacity short-range optical communication system.
基金This study was supported by the National Key Research and Development Project of China(2018YFD060024-04).
文摘Tree diversity has long been considered a key driver of insect herbivory in forest ecosystems.However,studies have given contradictory results:increased tree diversity can have positive,negative or neutral effects on insect herbivory.Since many issues can complicate the tree-herbivore interactions,the descriptor‘tree diversity’per se actually has only limited explanatory power for insect herbivory.Particularly,in addition to the direct bottom-up effects on insect herbivores,tree diversity may have stronger indirect top-down effects via natural enemies of insect herbivores.However,most research has addressed only direct bottom-up impacts.In fact,insect herbivory is the result of complex interactions(food webs)among all the species in a community.Although it is hard to integrate all functionally important species and dynamic information into food webs,the effects of tree diversity on insect herbivory are highly dependent on the dominant species at different trophic levels.It is important and practical to simultaneously consider the characteristics of main trees,herbivores,and natural enemies when attempting to predict the overall effects of forest tree diversity on insect herbivory.In order to ensure comparability between studies,it is necessary to classify them according to the descriptors of insect herbivory and tree diversity,and to compare results within each category.These measures might enhance our understanding of the mechanisms by which tree diversity drives insect herbivory and,in turn,help to develop sustainable pest management strategies for forests.
基金supported by the Science and Technology Program of Sichuan Province, China (Grant No. 23NSFSC1097)。
文摘To explore the effect of non-uniform polarization on orbital angular momentum(OAM) in anisotropic medium, in this work investigated are the evolution of the spiral spectra and OAM densities of non-uniformly polarized vortex(NUPV)beams in uniaxial crystals propagating orthogonal to the optical axis, and also the case of uniformly polarized vortex(UPV)beams with left-handed elliptical polarization. In the input plane, the NUPV beams present their spiral spectra of m-mode concentrated at m = l ± 1 modes rather than m = l mode, and reveal the relation among topological charge l, mode of spiral spectra m and the power weight value Rmexpressed by l=∑^(∞)_(m)=-∞Rm. is still satisfied for UPV beams in uniaxially anisotropic crystals, whereas for NUPV beams their relations are no longer valid owing to non-uniform polarization. Furthermore, the analysis indicates that the asymmetrical distribution of power weight of spiral spectra and the non-zero value in the sum of longitudinal OAM densities originate from the initial non-uniform polarization and anisotropy in uniaxial crystals rather than topological charges. In addition, the relation between spiral spectrum and longitudinal OAM density is numerically discussed. This work may provide an avenue for OAM-based communications,optical metrology, and imaging by varying the initial non-uniform polarization.
基金We are grateful for the financial support from National Natural Science Foundation of China(51703258,81772449 and 81971081)Guangzhou science technology and innovation commission(201804010309 and 201803010090)Science,Technology&Innovation Commission of Shenzhen Municipality(JCYJ20180307154606793 and JCYJ20180507181654186).
文摘Black phosphorus(BP)nano-materials,especially BP quantum dots(BPQDs),performs outstanding photothermal antitumor effects,excellent biocompatibility and biodegradability.However,there are several challenges to overcome before offering real benefits,such as poor stability,poor dispersibility as well as difficulty in tailoring other functions.Here,a“three-in-one”mitochondria-targeted BP nano-platform,called as BPQD-PEG-TPP,was designed.In this nano-platform,BPQDs were covalently grafted with a heterobifunctional PEG,in which one end was an aryl diazo group capable of reacting with BPQDs to form a covalent bond and the other end was a mitochondria-targeted triphenylphosphine(TPP)group.In addition to its excellent near-infrared photothermal properties,BPQD-PEG-TPP had much enhanced stability and dispersibility under physiological conditions,efficient mitochondria targeting and promoted ROS production through a photothermal effect.Both in vitro and in vivo experiments demonstrated that BPQD-PEG-TPP performed much superior photothermal cytotoxicity than BPQDs and BPQD-PEG as the mitochondria targeted PTT.Thus this“three-in-one”nanoplatform fabricated through polymer grafting,with excellent stability,dispersibility and negligible side effects,might be a promising strategy for mitochondria-targeted photothermal cancer therapy.
基金Project supported by the Space Application System of China Manned Space Programthe National Natural Science Foundation of China(Grant Nos.12072200 and 12002213)。
文摘We employ a Hall-effect magnetic sensor array to accurately track the trajectory of a single magnetic sphere,referred to as the“intruder,”within a three-dimensional vibro-fluidized granular bed to unravel the underlying physical mechanism governing the motion of the intruder.Within the acceleration range of 3.5 g≥Γ≥1.5 g,we find that,regardless of the intruder's initial position,it consistently reaches the same equilibrium depth when the vibration acceleration(Γ)and frequency(ω)are fixed.ForΓ≤2.5 g,the equilibrium position lies on the surface of the granular bed,while forΓ>2.5 g,it shifts below the surface.Additionally,intruders with different densities exhibit varying equilibrium depths,with higher density resulting in a deeper equilibrium position.To understand the mechanism behind the intruder's upward or downward motion,we measure its rising or sinking velocities under different vibration parameters.Our findings demonstrate that the rising velocity of the intruder,under varying vibration accelerations(Γ)and frequencies(ω),can be collapsed using the ratioΓ/ω,while the sinking velocity remains unaffected by the vibration strength.This confirms that the upward motion of the larger sphere,associated with the Brazil nut effect,primarily arises from the void-filling mechanism of the bed particles.Furthermore,our experiments reveal that the presence of convection within the bed particles has minimal impact on the motion of the intruder.
基金the National Natural Science Foundation of China(Nos.51878354&51308301)the Natural Science Foundation of Jiangsu Province(Nos.BK20181402&BK20130978)+1 种基金Six Talent Peak High-Level Projects of Jiangsu Province(No.JZ029)Qinglan Project of Jiangsu Higher Education Institutions and the Ministry of Housing and Urban-Rural Science Project of Jiangsu Province under Grant No.JS2021ZD10。
文摘Fiber reinforced polymer(FRP)has been used in the construction industry because of its advantages such as high strength,light weight,corrosion resistance,low density and high elasticity.This paper presents a review of bonding techniques adopted to strengthen timber beams using FRP to achieve larger spans.Different methods of bonding between FRP and timber beams have been summarized with a focus on the influencing factors and their effects as well as relevant bond-slip models proposed for fundamental understanding.Experimental investigations to evaluate the flexural performance of timber beams strengthened by FRP bars,sheets and wraps have also been critically reviewed to identify key influencing parameters.Limited research available on the shear performance of FRP reinforced timber beams have been analyzed to determine the influencing factors of the shear performance in timber-FRP beams.The paper finally presents an overall summary of the current-state-of-the-art and proposes some future research directions in the field.
基金supported by a grant from the National Natural Science Foundation of China(81771722)
文摘To the Editor:Graft versus host disease(GVHD)occurs when the immunocompetent cells from the donor mount an immune response against the tissues of the host[1].It is commonly seen in the patients who received hematopoietic stem cell transplantation(HSCT).GVHD is a rare but lethal complication in orthotopic liver