Here, we infer the historical biogeography and evolutionary diversification of the genus Lilium. For this purpose, we used the complete plastomes of 64 currently accepted species in the genus Lilium(14plastomes were n...Here, we infer the historical biogeography and evolutionary diversification of the genus Lilium. For this purpose, we used the complete plastomes of 64 currently accepted species in the genus Lilium(14plastomes were newly sequenced) to recover the phylogenetic backbone of the genus and a timecalibrated phylogenetic framework to estimate biogeographical history scenarios and evolutionary diversification rates of Lilium. Our results suggest that ancient climatic changes and geological tectonic activities jointly shaped the distribution range and drove evolutionary radiation of Lilium, including the Middle Miocene Climate Optimum(MMCO), the late Miocene global cooling, as well as the successive uplift of the Qinghai-Tibet Plateau(QTP) and the strengthening of the monsoon climate in East Asia during the late Miocene and the Pliocene. This case study suggests that the unique geological and climatic events in the Neogene of East Asia, in particular the uplift of QTP and the enhancement of monsoonal climate, may have played an essential role in formation of uneven distribution of plant diversity in the Northern Hemisphere.展开更多
目的探讨甲状腺摄99mTcO4-功能显像、彩色超声多普勒检查及其两者联合检查,对甲状腺结节性质的诊断价值。方法对我院2014年8月至2018年9月期间同时行超声检查及核素显像并有病理结果对照的112例患者共147个结节进行回顾性分析,对比超声...目的探讨甲状腺摄99mTcO4-功能显像、彩色超声多普勒检查及其两者联合检查,对甲状腺结节性质的诊断价值。方法对我院2014年8月至2018年9月期间同时行超声检查及核素显像并有病理结果对照的112例患者共147个结节进行回顾性分析,对比超声和核素检查及其两者联合检查对甲状腺结节的诊断效能并探讨单发良恶性结节半定量参数的差异。结果(1)其中147个结节中经病理诊断证实为甲状腺癌16个,良性甲状腺结节131个。(2)甲状腺摄锝99mTcO4-功能显像、彩超检查及两者联合的对甲状腺结节诊断的敏感性分别为75.0%、43.8%和93.8%(χ2=3.329、2.133、9.309,P=0.072、0.144、0.001),特异性分别为65.6%、84.7%和58.0%(χ2=12.788、1.617、22.884,P<0.001、0.203、<0.001),准确率分别为66.7%、80.3%和61.9%(χ2=6.980、0.726、12.065,P=0.008、0.394、<0.001),假阳性率分别为34.4%、15.3%和42.0%(χ2=12.788、1.617、22.884,P<0.001、0.203、<0.001),假阴性率分别为25.0%、56.2%和6.2%(χ2=3.329、2.133、9.309,P=0.072、0.144、0.001)。(3)甲状腺良性结节组与甲状腺癌组的甲状腺直观指数(visualindex of thyroid uptake,VITU)分别为4.18±3.94和2.35±1.60(t=1.326,P=0.190),良性甲状腺结节与甲状腺癌的摄99mTcO4-功能(病变部位的放射性浓度/周围正常甲状腺组织放射性浓度L/N)分别为0.53±0.39和0.49±0.18(t=0.212,P=0.833)。结论甲状腺99mTcO4-功能显像对甲状腺恶性结节的鉴别诊断有一定的应用价值,并能提供甲状腺的功能信息,超声联合核素显像能减少恶性结节的漏诊率。展开更多
基金financially supported by the National Natural Science Foundation of China (31872673)Yunnan Revitalization Talent Support Program “Top Team” Project (202305AT350001)the NSFC-Joint Foundation of Yunnan Province (U1802287)。
文摘Here, we infer the historical biogeography and evolutionary diversification of the genus Lilium. For this purpose, we used the complete plastomes of 64 currently accepted species in the genus Lilium(14plastomes were newly sequenced) to recover the phylogenetic backbone of the genus and a timecalibrated phylogenetic framework to estimate biogeographical history scenarios and evolutionary diversification rates of Lilium. Our results suggest that ancient climatic changes and geological tectonic activities jointly shaped the distribution range and drove evolutionary radiation of Lilium, including the Middle Miocene Climate Optimum(MMCO), the late Miocene global cooling, as well as the successive uplift of the Qinghai-Tibet Plateau(QTP) and the strengthening of the monsoon climate in East Asia during the late Miocene and the Pliocene. This case study suggests that the unique geological and climatic events in the Neogene of East Asia, in particular the uplift of QTP and the enhancement of monsoonal climate, may have played an essential role in formation of uneven distribution of plant diversity in the Northern Hemisphere.
文摘目的探讨甲状腺摄99mTcO4-功能显像、彩色超声多普勒检查及其两者联合检查,对甲状腺结节性质的诊断价值。方法对我院2014年8月至2018年9月期间同时行超声检查及核素显像并有病理结果对照的112例患者共147个结节进行回顾性分析,对比超声和核素检查及其两者联合检查对甲状腺结节的诊断效能并探讨单发良恶性结节半定量参数的差异。结果(1)其中147个结节中经病理诊断证实为甲状腺癌16个,良性甲状腺结节131个。(2)甲状腺摄锝99mTcO4-功能显像、彩超检查及两者联合的对甲状腺结节诊断的敏感性分别为75.0%、43.8%和93.8%(χ2=3.329、2.133、9.309,P=0.072、0.144、0.001),特异性分别为65.6%、84.7%和58.0%(χ2=12.788、1.617、22.884,P<0.001、0.203、<0.001),准确率分别为66.7%、80.3%和61.9%(χ2=6.980、0.726、12.065,P=0.008、0.394、<0.001),假阳性率分别为34.4%、15.3%和42.0%(χ2=12.788、1.617、22.884,P<0.001、0.203、<0.001),假阴性率分别为25.0%、56.2%和6.2%(χ2=3.329、2.133、9.309,P=0.072、0.144、0.001)。(3)甲状腺良性结节组与甲状腺癌组的甲状腺直观指数(visualindex of thyroid uptake,VITU)分别为4.18±3.94和2.35±1.60(t=1.326,P=0.190),良性甲状腺结节与甲状腺癌的摄99mTcO4-功能(病变部位的放射性浓度/周围正常甲状腺组织放射性浓度L/N)分别为0.53±0.39和0.49±0.18(t=0.212,P=0.833)。结论甲状腺99mTcO4-功能显像对甲状腺恶性结节的鉴别诊断有一定的应用价值,并能提供甲状腺的功能信息,超声联合核素显像能减少恶性结节的漏诊率。
