Magnetic proximity effect in the two-dimensional ε-Fe_(2)O_(3)/NbSe_(2)heterojunction

Two-dimensional(2D)magnet/superconductor heterostructures can promote the design of artificial materials for exploring 2D physics and device applications by exotic proximity effects.However,plagued by the low Curie temperature and instability in air,it is hard to realize practical applications for the reported layered magnetic materials at present.In this paper,we developed a space-confined chemical vapor deposition method to synthesize ultrathin air-stable ε-Fe_(2)O_(3) nanosheets with Curie temperature above 350 K.The ε-Fe_(2)O_(3)/NbSe_(2) heterojunction was constructed to study the magnetic proximity effect on the superconductivity of the NbSe_(2) multilayer.The electrical transport results show that the subtle proximity effect can modulate the interfacial spin–orbit interaction while undegrading the superconducting critical parameters.Our work paves the way to construct 2D heterojunctions with ultrathin nonlayered materials and layered van der Waals(vdW)materials for exploring new physical phenomena.

Chronic spinal cord compression associated with intervertebral disc degeneration in SPARC-null mice

Chronic spinal cord compression(CSCC)is induced by disc herniation and other reasons,leading to movement and sensation dysfunction,with a serious impact on quality of life.Spontaneous disc herniation rarely occurs in rodents,and therefore establishing a chronic spinal cord compression(CSCC)animal model is of crucial importance to explore the pathogenesis and treatment of CSCC.The absence of secreted protein,acidic,and rich in cysteine(SPARC)leads to spontaneous intervertebral disc degeneration in mice,which resembles human disc degeneration.In this study,we evaluated whether SPARC-null mice may serve as an animal model for CSCC.We performed rod rotation test,pain threshold test,gait analysis,and Basso Mouse Scale score.Our results showed that the motor function of SPARC-null mice was weakened,and magnetic resonance images revealed compression at different spinal cord levels,particularly in the lumbar segments.Immunofluorescence staining and western blot assay showed that the absence of SPARC induced apoptosis of neurons and oligodendrocytes,activation of microglia/macrophages with M1/M2 phenotype and astrocytes with A1/A2 phenotype;it also activated the expression of the NOD-like receptor protein 3 inflammasome and inhibited brain-derived neurotrophic factor/tyrosine kinase B signaling pathway.Notably,these findings are characteristics of CSCC.Therefore,we propose that SPARC-null mice may be an animal model for studying CSCC caused by disc herniation.

Metal-organic frameworks with mixed-ligands strategy as heterogeneous nucleation center to assist crystallization for efficient and stable perovskite solar cells

Deep-level defects and random oriented configuration in perovskite crystallization process would cause the nonradiative recombination and further affect the performance of perovskite solar cells(PSCs).Herein,two metal-organic frameworks(MOFs)with tunable Lewis-base passivation sites have been constructed(Cd-Httb and Cd-Httb-BDC,Httb=5-(4-(1H-1,2,4-triazole-1-yl)benzyl)-1h-tetrazole,BDC=1,4-dicarboxybenzene)to eliminate deep-level defects and simultaneously as nanostructured heterogeneous nucleation seed to assist the growth of large-grained perovskite films.Compared with the control and Cd-Httb,Cd-Httb-BDC designed with mix-ligands strategy exhibited the enhanced inducted effect on the crystallization and nucleation of high-quality perovskite films during annealing process.Consequently,the resultant Cd-Httb-BDC-modified device achieved higher power conversion efficiency(PCE)(22.18%)than the control(20.89%)and Cd-Httb(21.56%).Meanwhile,the unencapsulated Cd-Httb-BDC-modified device still maintained 90%of initial PCE after 1500 h in ambient conditions and exhibited enhanced thermal stability(85℃ in N_(2) atmosphere).This work presented a successful example of mixligands strategy on construction of high-quality MOF-assisted perovskite films for high-efficient and stable PSCs.

Fatal ventricular arrhythmias after osimertinib treatment for lung adenocarcinoma: a case report

Osimertinib,a third-generation epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKIs),is approved globally as the first-line treatment for patients with EGFR mutations(EGFRm:Ex19del/L858R)and T790M resistance mutations in advanced non-small cell lung cancer(NSCLC).[1−3]With its widespread use,the cardiotoxicity of osimertinib has been of great concern.According to the U.S.Food and Drug Administration Adverse Events Reporting System(FAERS),the main cardiac-related adverse events with EGFR-TKIs are heart failure,QT prolongation,atrial fibrillation,acute myocardial infarction and pericardial effusion,and osimertinib has a higher incidence of QT prolongation,heart failure and atrial fibrillation than other EGFR-TKIs.

藏医放血疗法对急性痛风局部及全身炎性因子的影响

目的:评价藏医放血疗法对急性痛风局部及全身炎性因子的影响。方法:选取2017年11月至2018年8月昌都市藏医院收治的急性痛风赤巴型患者30例作为研究对象,采取藏医放血疗法治疗,取放血局部最初0 mL,30 mL,60 mL,90 mL时血液各5 mL,同时分别在放血至0 mL,30 mL,60 mL,90 mL时肘正中静脉取血5 mL,检测白细胞(WBC)、C-反应蛋白(CRP)、血尿酸(UA)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)和低氧诱导因子-1α(HIF-1α)水平。结果:放血后全身90 mL与0 mL UA比较,差异有统计学意义(P<0.01),90 mL与0 mL WBC、CRP比较,差异无统计学意义(P>0.05)。放血后全身90 mL与0 mL HIF-1α值比较,差异有统计学意义(P<0.01),90 mL与0 mL IL-1β、TNF-α值,差异无统计学意义(P>0.05)。放血后局部90 mL与0 mL IL-1β、TNF-α、HIF-1α水平比较,差异有统计学意义(P<0.01)。HIF-1α与IL-1β和TNF-α两者呈弱相关。结论:放血疗法通过改善局部组织缺氧,减少局部UA水平,进而导致局部IL-1β、TNF-α、HIF-1α下降,最终起到缓解急性痛风症状的作用。

藏医放血疗法对急性痛风全身及局部NLRP3、IL-4和CXCL2的影响

目的:评价藏医放血疗法对急性痛风全身和局部NLRP3、IL-4和CXCL2等影响。方法:选取符合纳入标准的急性痛风患者30例行藏医放血疗法治疗,分别在放血0 ml、30 ml、60 ml、90 ml时取局部和肘正中静脉血液各5 ml,检测炎性相关因子NLRP3、IL-1β和炎性抑制因子IL-4、TGF-β以及趋化因子CXCL2变化情况。结果:放血前后全身IL-1β、NLRP3、TGF-β、IL-4和CXCL2变化比较差异无统计学意义,放血前后局部IL-1β、NLRP3、TGF-β、IL-4和CXCL2比较差异有统计学意义,放血过程中0 ml和90 ml时局部与全身IL-1β、NLRP3、TGF-β、IL-4及CXCL2差异有统计学意义。结论:放血疗法所导致的局部IL-1β降低除了可能与放血过程中全身血液稀释作用有关,还与局部尿酸下降和IL-4及CXCL2升高所诱导的炎症反应减弱有关。

藏医放血疗法对急性痛风局部NLRP3、S100A8/A9和IL-1β的影响

目的:评价藏医放血疗法对急性痛风局部NLRP3、S100A8/A9和白细胞介素1β(interleukin-1β,IL-1β)的影响。方法:选取急性痛风患者30例,采取藏医放血疗法治疗,取放血局部最初及一次性放血量达到30、60、90 m L的患者放血部位血液各5 m L,检测IL-1β、NLRP3、TGF-β、S100A8/A9及血UA水平。结果:放血后局部IL-1β、S100A8/A9呈逐渐下降趋势,TGF-β、NLRP3呈逐渐上升趋势,放血90 mL时与放血0 mL时IL-1β、TGF-β、S100A8/A9和NLRP3水平均存在统计学差异(P<0.01)。放血过程中局部IL-1β和NLRP3存在相关性;局部IL-1β和S100A8/A9 90 mL时两者存在弱正相关;局部IL-1β和TGF-β无明显负相关性。结论:MSU下降可直接导致IL-β水平下降,随着放血量的继续增加,包括巨噬细胞表型转化在内的其他因素所发挥的降低IL-β作用可能增强,提示放血疗法不仅仅通过单一机制发挥作用,可能是多种途径共同作用的结果。

Glutamate receptor delocalization in postsynaptic membrane and reduced hippocampal synaptic plasticity in the early stage of Alzheimer's disease

Mounting evidence suggests that synaptic plasticity provides the cellular biological basis of learning and memory, and plasticity deficits play a key role in dementia caused by Alzheimer's disease. However, the mechanisms by which synaptic dysfunction contributes to the pathogenesis of Alzheimer's disease remain unclear. In the present study, Alzheimer's disease transgenic mice were used to determine the relationship between decreased hippocampal synaptic plasticity and pathological changes and cognitive-behavioral deterioration, as well as possible mechanisms underlying decreased synaptic plasticity in the early stages of Alzheimer's disease-like diseases. APP/PS1 double transgenic(5 XFAD; Jackson Laboratory) mice and their littermates(wild-type, controls) were used in this study. Additional 6-weekold and 10-week-old 5 XFAD mice and wild-type mice were used for electrophysiological recording of hippocampal dentate gyrus. For10-week-old 5 XFAD mice and wild-type mice, the left hippocampus was used for electrophysiological recording, and the right hippocampus was used for biochemical experiments or immunohistochemical staining to observe synaptophysin levels and amyloid beta deposition levels. The results revealed that, compared with wild-type mice, 6-week-old 5 XFAD mice exhibited unaltered long-term potentiation in the hippocampal dentate gyrus. Another set of 5 XFAD mice began to show attenuation at the age of 10 weeks, and a large quantity of amyloid beta protein was accumulated in hippocampal cells. The location of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor and N-methyl-D-aspartic acid receptor subunits in synaptosomes was decreased. These findings indicate that the delocalization of postsynaptic glutamate receptors and an associated decline in synaptic plasticity may be key mechanisms in the early onset of Alzheimer's disease. The use and care of animals were in strict accordance with the ethical standards of the Animal Ethics Committee of Capital Medical University,China on December 17, 2015(approval No. AEEI-2015-182).

Peroxymonosulfate activation by Fe-N-S co-doped tremella-like carbocatalyst for degradation of bisphenol A: Synergistic effect of pyridine N, Fe-Nx, thiophene S

Bisphenol A(BPA)has received increasing attention due to its long-term industrial application and persistence in environmental pollution.Iron-based carbon catalyst activation of peroxymonosulfate(PMS)shows a good prospect for effective elimination of recalcitrant contaminants in water.Herein,considering the problem about the leaching of iron ions and the optimization of heteroatoms doping,the iron,nitrogen and sulfur co-doped tremellalike carbon catalyst(Fe-NS@C)was rationally designed using very little iron,S-C_(3)N_(4) and low-cost chitosan(CS)via the impregnation-calcination method.The as-prepared Fe-NS@C exhibited excellent performance for complete removal of BPA(20 mg/L)by activating PMS with the high kinetic constant(1.492 min^(−1))in 15 min.Besides,the Fe-NS@C/PMS system not only possessed wide pH adaptation and high resistance to environmental interference,but also maintained an excellent degradation efficiency on different pollutants.Impressively,increased S-C_(3)N_(4) doping amount modulated the contents of different N species in Fe-NS@C,and the catalytic activity of Fe-NS@C-1-x was visibly enhanced with increasing SC_(3)N_(4) contents,verifying pyridine N and Fe-Nx as main active sites in the system.Meanwhile,thiophene sulfur(C-S-C)as active sites played an auxiliary role.Furthermore,quenching experiment,EPR analysis and electrochemical test proved that surface-bound radicals(·OH and SO_(4)^(·−))and non-radical pathways worked in the BPA degradation(the former played a dominant role).Finally,possible BPA degradation route were proposed.This work provided a promising way to synthesize the novel Fe,N and S co-doping carbon catalyst for degrading organic pollutants with low metal leaching and high catalytic ability.

Fe-N co-doped coral-like hollow carbon shell toward boosting peroxymonosulfate activation for efficient degradation of tetracycline: Singlet oxygen-dominated non-radical pathway

Fe-N co-doped coral-like hollow carbon shell (Fe-N-CS) was synthesized via a simply impregnation-pyrolysis method.The Fe-N-CS showed an excellent ability for activating peroxymonosulfate (PMS),which could degrade about 93.74%tetracycline (20 mg/L) in 12 min.The Fe-N-CS/PMS system exhibited a good anti-interference capacity of various pH,inorganic anions,HA and different water qualities.More importantly,the Fe nanoparticles were anchored uniformly in the carbon layer,effectively limiting the metal leaching.The quenching tests and electron spin resonance (ESR) manifested that non-radical singlet oxygen (1O_(2))was the main reactive oxygen species (ROS) for TC degradation.The mechanism study showed that Fe nanoparticles,defect and graphite N played a key role in activating PMS to produce ROS.Moreover,three probable degradation pathways were proposed by using LC-MS measurements.Generally,this work had a new insight for the synthesis of heterogeneous Fe-N-C catalysts in the advanced oxidation process based on PMS.

Combined spatial frequency spectroscopy analysis with visible resonance Raman for optical biopsy of human brain metastases of lung cancers

The purpose of this study is to examine optical spatial frequency spectroscopy analysis(SFSA)combined with visible resonance Raman(VRR)spectroscopic method,for thefirst time,to discriminate human brain metastases of lung cancers adenocarcinoma(ADC)and squamous cell carcinoma(SCC)from normal tissues.A total of 31 label-free micrographic images of three type of brain tissues were obtained using a confocal micro-Raman spectroscopic system.VRR spectra of the corresponding samples were synchronously collected using excitation wavelength of 532 nm from the same sites of the tissues.Using SFSA method,the difference in the randomness of spatial frequency structures in the micrograph images was analyzed using Gaussian functionfitting.The standard deviations,calculated from the spatial frequencies of the micrograph images were then analyzed using support vector machine(SVM)classifier.The key VRR biomolecularfingerprints of carotenoids,tryptophan,amide II,lipids and proteins(methylene/methyl groups)were also analyzed using SVM classifier.All three types of brain tissues were identified with high accuracy in the two approaches with high correlation.The results show that SFSA–VRR can potentially be a dual-modal method to provide new criteria for identifying the three types of human brain tissues,which are on-site,real-time and label-free and may improve the accuracy of brain biopsy.

Partial Collapsing Degeneration of Floer Trajectories and Adiabatic Gluing

In the present paper,we study partial collapsing degeneration of Hamiltonian-perturbed Floer trajectories for an adiabatic ε-family and its reversal adiabatic gluing,as the prototype of the partial collapsing degeneration of 2-dimensional(perturbed)J-holomorphic maps to 1-dimensional gradient segments.We consider the case when the Floer equations are S^(1)-invariant on parts of their domains whose adiabatic limit has positive length as ε→0,which we call thimble-flow-thimble configurations.The main gluing theorem we prove also applies to the case with Lagrangian boundaries such as in the problem of recovering holomorphic disks out of pearly configuration.In particular,our gluing theorem gives rise to a new direct proof of the chain isomorphism property between the Morse-Bott version of Lagrangian intersection Floer complex of L by Fukaya-Oh-Ohta-Ono and the pearly complex of L Lalonde and Biran-Cornea.It also provides another proof of the present authors’earlier proof of the isomorphism property of the PSS map without involving the target rescaling and the scale-dependent gluing.

Phytic acid-derivative Co_(2)B-CoPO_x coralloidal structure with delicate boron vacancy for enhanced hydrogen generation from sodium borohydride

Application of transition metal boride(TMB) catalysts towards hydrolysis of NaBH_(4) holds great significance to help relieve the energy crisis. Herein, we present a facile and versatile metal-organic framework(MOF) assisted strategy to prepare Co_(2)B-CoPO_x with massive boron vacancies by introducing phytic acid(PA) cross-linked Co complexes that are acquired from reaction of PA and ZIF-67 into cobalt boride. The PA etching effectively breaks down the structure of ZIF-67 to create more vacancies, favoring the maximal exposure of active sites and elevation of catalytic activity. Experimental results demonstrate a drastic electronic interaction between Co and the dopant phosphorous(P), thereby the robustly electronegative P induces electron redistribution around the metal species, which facilitates the dissociation of B-H bond and the adsorption of H_(2)O molecules. The vacancy-rich Co_(2)B-CoPO_x catalyst exhibits scalable performance, characterized by a high hydrogen generation rate(HGR) of 7716.7 m L min^(-1)g^(-1) and a low activation energy(Ea) of 44.9 k J/mol, rivaling state-of-the-art catalysts. This work provides valuable insights for the development of advanced catalysts through P doping and boron vacancy engineering and the design of efficient and sustainable energy conversion systems.

Advances in ground heat exchangers for space heating and cooling:Review and perspectives

As a renewable energy source,geothermal energy has been widely used to provide space heating and cooling for buildings.The thermal performance of ground heat exchanger(GHE)is significant for the operating efficiency of the ground source heat pump(GSHP)systems.This paper presents a comprehensive review of developments and advances of three kinds of GHE,including vertical borehole GHE(VBGHE),Pile GHE(PGHE),and deep borehole GHE(DBGHE)which are currently popular in larger GSHP systems.Firstly,analytical models proposed to ana-lyze heat transfer process of VBGHE with different geological conditions are summarized,such as homogenous or heterogeneous ground,with or without groundwater advection.Numerical and short-time step models and measures to improve GHE thermal performance are also reviewed.Secondly,a summary of research advances in PGHE is provided,which includes the heat transfer models of PGHE,the effects of geometric structure,oper-ation modes,pile spacing,use of phase change material(PCM),thermal properties of PCM,thermo-mechanical behavior and/or thermal performance of PGHE.The effects of groundwater flow direction and velocity on PGHE are also summarized in brief.Lastly,models of three kinds of DBGHEs,i.e.,deep coaxial GHE(DCGHE),deep U-bend GHE(DUGHE)and super-long gravity heat pipe(SLGHP),are reviewed.The physical bases of the dif-ferent analytical models are elaborated and also their advantages and disadvantages are described.Advances in numerical modelling and improving numerical model calculation speed of DCBHE,DCBHE array,and DUBHE are summarized.The review provides a meaningful reference for the further study of GHEs.

三果汤散对急性痛风局部静脉全血黏度、红细胞分析及炎性因子的影响

目的:评价三果汤散对急性痛风局部静脉全血黏度、红细胞分析及炎性因子的影响。方法:将2018年10月至2019年10月就诊于昌都市藏医院的赤巴型痛风患者分为三果汤散组、对照组,最终满足条件放血病例分别为36、38例,三果汤散组给予三果汤散治疗,每日早晚2次,每次4g水冲服,连续服用5d后行放血治疗;对照组未采取任何治疗,仅观察5d后行放血治疗。两组自0d(用采血针自痛风脉处取血)、放血开始时和结束时取所放静脉血各5mL,对所采血液标本行全血黏度、红细胞(RBC)、血红蛋白(HGB)、红细胞压积(HCT)、氧分压(PO2)、血尿酸(UA)、白介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)、缺氧诱导因子1α(HIF-1α)检测。结果:放血量中位数(52.50mL vs 65.50mL)比较,三果汤散组显著少于对照组(P<0.01),放血过程中RBC、HGB、HCT无明显变化,两组放血结束时PO2较0d、放血开始时显著升高(P<0.05),三果汤散组各全血黏度随治疗进行呈逐渐下降趋势,两组间差异均有统计学意义(P<0.05),三果汤散组IL-1β、TNF-α、HIF-1α随治疗进行呈逐渐下降趋势,两组放血结束时与0d、放血开始时比较,各炎性因子显著降低(P<0.05)。两组UA随放血过程进行呈下降趋势,放血结束时两组间差异有统计学意义(P<0.05)。结论:三果汤散通过改善局部PO2、UA、各全血黏度及炎性因子水平,加速病血与津血分离,最终实现减少放血量的目的。

藏医放血疗法治疗痛风研究进展

藏医对于痛风的治疗有其独特的治疗理念,尤其是藏医的放血疗法对于急性痛风性关节炎治疗效果显著,已有多个文献就藏医放血疗法的临床疗效进行评价,结果显示放血疗法整体治疗效果满意。放血部位多选择发作关节附近的血管,每次放血量约为2~400mL不等。文章通过文献检索,通过对放血前期准备、放血部位、放血量的多少及放血后管理等进行系统回顾,综合评价藏医放血疗法对痛风的治疗效果,以期为今后的工作开展提供帮助。

Superior trichloroethylene removal from water by sulfide-modified nanoscale zero-valent iron/graphene aerogel composite

Sulfide-modified nanoscale zero-valent iron(S-nZVI) is a promising material for removal of organic pollutants from water, but S-nZVI nanoparticles(NPs) easily agglomerate and have poor contact with organic contaminants.Herein, we propose a new S-nZVI/graphene aerogel(S-nZVI/GA) composite which exhibits superior removal capability for trichloroethylene(TCE) from water.Three-dimensional porous graphene aerogel(GA) can improve the efficiency of electron transport, enhance the adsorption of organic pollutants and restrain the agglomeration of the core-shell S-nZVI NPs.The TCE removal rates of Fe S, nZVI, GA and S-nZVI were 27.8%, 42%, 63% and 75% in 2 hr, respectively.Furthermore, TCE was completely removed within 50 min by S-nZVI/GA.The TCE removal rate increased with increasing p H and temperature, and TCE removal followed the pseudo-first-order kinetic model.The results demonstrate the great potential of S-nZVI/GA composite as a low-cost,easily separated and superior monolithic adsorbent for removal of organic pollutants.

Oil spill cleanup from sea water by carbon nanotube sponges

Oil spills in the sea have caused many serious environmental problems worldwide. In this study, carbon nanotube （CNT） sponges were used to cleanup oil slicks on sea waters. This method was compared with two traditional representative sorbents, including polypropylene fiber fabric and woolen felt. The CNT sponges had a larger oil sorption capacity than the other two sorbents. The maximum oil sorption capacity （Qm） of the CNT sponge was 92.30 g/g, which was 12 to 13.5 times larger than the Qm of the other two sorbents （the Qm of the polypropylene fiber fabric and woolen felt were 7.45 and 6.74 g/g, respectively）. In addition, unlike the other two sorbents, the CNT sponge was super- hydrophobic and did not adsorb any water during oil spill cleanup. CNT sponges are potentially very useful for cleaning up oil spills from sea water.

化学掺杂笼目结构超导体CsV_(3-x)Ti_(x)Sb_(5)及其两个显著物相

钒基笼目结构(kagome)超导体CsV_(3)Sb_(5)展现出反常霍尔效应(AHE)、电荷密度波(CDW),相列序和配对密度波(PDW)等新奇物性而得到了广泛关注.在kagome层进行化学取代掺杂是直接揭示内禀物性相互关联机制的最有效途径之一,但目前尚未见报道.本文成功制备出钛(Ti)化学掺杂的CsV_(3)Sb_(5)单晶,其中Ti原子直接取代kagome层中的部分V原子.CsV_(3-x)Ti_(x)Sb_(5)展现出2个显著不同的物相:少取代相展示出一个非常规V形的超导能隙,同时与减弱的长程CDW、PDW、AHE和相列序共存;多取代相则为常规U形的超导能隙并与短程CDW共存,同时长程CDW、AHE、PDW和具有二重对称性的面内磁电阻均消失.除Ti元素外,作者还成功制备了Cr和Nb掺杂的CsV_(3)Sb_(5)单晶.该研究成果开辟了制备化学掺杂笼目超导体的新方法以及研究不同电子关联态和超导配对精确调控的新平台.

Tetracycline removal via adsorption and metal-free catalysis with 3D macroscopic N-doped porous carbon nanosheets:Non-radical mechanism and degradation pathway

Recently,metal-based carbon materials have been verified to be an effective persulfate activator,but secondary pollution caused by metal leaching is inevitable.Hence,a green metalfree 3D macroscopic N-doped porous carbon nanosheets(NPCN)was synthesized successfully.The obtained NPCN showed high adsorption capacity of tetracycline(TC)and excellent persulfate(PS)activation ability,especially when calcined at 700℃(NPCN-700).The maximum adsorption capacity of NPCN-700 was 121.51 mg/g by H-bonds interactions.Moreover,the adsorption process followed pseudo-second-order kinetics model and Langmuir adsorption isotherm.The large specific surface area(365.27 mg/g)and hierarchical porous structure of NPCN-700 reduced the mass transfer resistance and increased the adsorption capacity.About 96.39%of TC was removed after adding PS.The effective adsorption of the catalyst greatly shortened the time for the target organic molecules to migrate to the catalyst.Moreover,the NPCN-700 demonstrated high reusability with the TC removal rate of 80.23%after 4 cycles.Quenching experiment and electron paramagnetic resonance(EPR)test confirmed the non-radical mechanism dominated by ^(1)O_(2).More importantly,the C=O groups,defects and Graphitic N acted as active sites to generate ^(1)O_(2).Correspondingly,electrochemical measurement revealed the direct electron transfer pathway of TC degradation.Finally,multiple degradation intermediates were recognized by the LC-MS measurement and three possible degradation pathways were proposed.Overall,the prepared NPCN had excellent application prospects for removal of antibiotics due to its remarkable adsorption and catalytic degradation capabilities.