Aluminum is concerned as a possible cause of many diseases.To investigate the long-term A1 biokinetics and bioavailability in various kinds of Al-contained medicine and food,an accelerator mass spectrometry(AMS)based ...Aluminum is concerned as a possible cause of many diseases.To investigate the long-term A1 biokinetics and bioavailability in various kinds of Al-contained medicine and food,an accelerator mass spectrometry(AMS)based on the HI-13 tandem has been established for biological analysis with ^(26)A1(T_(1/2) = 716,000 years) as the tracer.In this paper,the animal tracing,sample preparation procedure and ^(26)A1-AMS measurement are presented.The sample preparation procedure has been simplified.A high sensitivity of 5×10^(-15) for ^(26)A1/^(27)A1 has been achieved.Two phases were found before and after a break time(t_b)for the ^(26)A1 retained in blood and brain,with t_b≈8 and12 h after the ^(26)Al tracer injection,respectively.展开更多
基金National Natural Science Foundation of China(No.52201103)Natural Science Basis Research Plan in Shaanxi Province of China(No.2023JCYB445)Fundamental Research Funds for the Central Universities of CHD(Nos.300102122201,300102122106)。
基金Projects(51661005,U1612442)supported by the National Natural Science Foundation of ChinaProject(QKHJC[2017]1025)supported by the Natural Science Foundation of Guizhou Province,ChinaProject(2018JJ3560)supported by the Natural Science Foundation of Hunan Province,China。
基金supported by National Natural Science Foundation of China(No.41166002)Guangxi Natural Science Foundation(Nos.2012GXNSFBA053004,2013GXNSFFA019001)Guangxi New Century Education Project(No.2013JGZ100)
文摘Aluminum is concerned as a possible cause of many diseases.To investigate the long-term A1 biokinetics and bioavailability in various kinds of Al-contained medicine and food,an accelerator mass spectrometry(AMS)based on the HI-13 tandem has been established for biological analysis with ^(26)A1(T_(1/2) = 716,000 years) as the tracer.In this paper,the animal tracing,sample preparation procedure and ^(26)A1-AMS measurement are presented.The sample preparation procedure has been simplified.A high sensitivity of 5×10^(-15) for ^(26)A1/^(27)A1 has been achieved.Two phases were found before and after a break time(t_b)for the ^(26)A1 retained in blood and brain,with t_b≈8 and12 h after the ^(26)Al tracer injection,respectively.
基金supported by the National Natural Science Foundations of China(11775157 and 41888101)the National Key Research and Development Program of China(2020YFA0607700)。