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Ginkgo biloba extract(EGb 761) attenuates lung injury induced by intestinal ischemia/reperfusion in rats:Roles of oxidative stress and nitric oxide 被引量:24
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作者 ke-xuan liu Wei-Kang Wu +1 位作者 Wei He Chui-Liang liu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第2期299-305,共7页
AIM: To investigate the effect of ginkgo biloba extract (EGb 761) on lung injury induced by intestinal ischemia/ reperfusion ( Ⅱ/R). METHODS: The rat model of Ⅱ/R injury was produced by damping the superior me... AIM: To investigate the effect of ginkgo biloba extract (EGb 761) on lung injury induced by intestinal ischemia/ reperfusion ( Ⅱ/R). METHODS: The rat model of Ⅱ/R injury was produced by damping the superior mesenteric artery for 60 min followed by reperfusion for 180 min. The rats were randomly allocated into sham, Ⅱ/R, and EGb +Ⅱ/R groups. In EGb +Ⅱ/R group, EGb 761 (100 mg/kg per day) was given via a gastric tube for 7 consecutive days prior to surgery. Rats in Ⅱ/R and sham groups were treated with equal volumes of the vehicle of EGb 761. Lung injury was assessed by light microscopy, wet-todry lung weight ratio (W/D) and pulmonary permeability index (PPT). The levels of malondialdehyde (MDA) and nitrite/nitrate (NO2/NO3), as well as the activities of superoxide dismutase (SOD) and myeloperoxidase (MPO) were examined. Western blot was used to determine the expression of inducible nitric oxide synthase (iNOS). RESULTS: EGb 761 markedly improved mean arterial pressure and attenuated lung injury, manifested by the improvement of histological changes and significant decreases of pulmonary W/D and PPT (P 〈 0.05 or 0.01).Moreover, EGb 761 markedly increased SOD activity, reduced MDA levels and MPO activity, and suppressed NO generation accompanied by down-regulation of iNOS expression (P 〈 0.05 or 0.01). CONCLUSION: The results indicate that EGb 761 has a protective effect on lung injury induced by Ⅱ /R, which may be related to its antioxidant property and suppressions of neutrophil accumulation and iNOS- induced NO generation. EGb 761 seems to be an effective therapeutic agent for critically ill patients with respiratory failure related to Ⅱ/R. 展开更多
关键词 Ginkgo biloba Extract INTESTINE Reperfusion injury LUNG Adult respiratory distress syndrome Vascular permeability Nitric oxide Lipid peroxidation
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Expert consensus on the perioperative management of patients with sepsis 被引量:4
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作者 Jun-ping Chen Xiang-ming Fang +19 位作者 Xiao-ju Jin Rong-tian Kang ke-xuan liu Jin-bao Li Yan Luo Zhi-jie Lu Chang-hong Miao Han-xiang Ma Wei Mei Yang-wen Ou Si-hua Qi Zai-sheng Qin Guo-gang Tian An-shi Wu Dong-xin Wang Tian Yu Yong-hao Yu Jing Zhao Ming-zhang Zuo Shi-hai Zhang 《World Journal of Emergency Medicine》 CAS 2015年第4期245-260,共16页
INTRODUCTION Sepsis is defined as an infection associated with systemic manifestations of inflammation, which has become the most common complication in the perioperative period caused by severe burn/trauma and major ... INTRODUCTION Sepsis is defined as an infection associated with systemic manifestations of inflammation, which has become the most common complication in the perioperative period caused by severe burn/trauma and major surgical operation.[1,2] The incidence of sepsis in adults is estimated to be 149–240/100 000 per year, and that of severe sepsis and septic shock is 56–91/100 000 per year. In the last decade, the short-term mortality of sepsis has declined to around 20% in developed countries partly due to the international Surviving Sepsis Campaign (SSC), while the mortality remains very high (50%–80%) in 1–5 years after discharge from hospitals.[3–7] Thus, sepsis and its subsequent severe sepsis and septic shock are currently major issues in the field of medical and health care. 展开更多
关键词 Expert consensus perioperative management patients with sepsis
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