BACKGROUND Biliary adenofibroma(BF)is a rare benign epithelial tumor with the possibility of malignant transformation.Its main pathological feature is a well-defined cystic or honeycomb mass.BF has no specific clinica...BACKGROUND Biliary adenofibroma(BF)is a rare benign epithelial tumor with the possibility of malignant transformation.Its main pathological feature is a well-defined cystic or honeycomb mass.BF has no specific clinical manifestations or laboratory and imaging findings;thus,it is easily misdiagnosed before surgery.This report describes a case in which biliary cystadenoma was misdiagnosed preoperatively and BF was diagnosed postoperatively.The imaging features,particularly the magnetic resonance imaging(MRI)features,were analyzed and summarized.CASE SUMMARY A 68-year-old Chinese man was admitted to our hospital with a 2-mo history of abdominal discomfort.Following admission to our hospital,laboratory examinations showed normal tumor marker concentrations and liver function.Hepatocellular carcinoma was considered after contrast-enhanced ultrasound examination.MRI suggested the possibility of cystadenoma of the bile duct.However,postoperative pathological examination confirmed the diagnosis of BF.No local recurrence was found 1 mo after surgery.CONCLUSION Our objective is to highlight the imaging diagnostic value of BF,especially on an MRI enhanced scan with gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid.展开更多
Background:It is crucial to differentiate accurately glioma recurrence and pseudoprogression which have entirely different prognosis and require different treatment strategies.This study aimed to assess the diagnostic...Background:It is crucial to differentiate accurately glioma recurrence and pseudoprogression which have entirely different prognosis and require different treatment strategies.This study aimed to assess the diagnostic accuracy of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)as a tool for distinguishing glioma recurrence and pseudoprogression.Methods:According to particular criteria of inclusion and exclusion,related studies up to May 1,2019,were thoroughly searched from several databases including PubMed,Embase,Cochrane Library,and Chinese biomedical databases.The quality assessment of diagnostic accuracy studies was applied to evaluate the quality of the included studies.By using the"mada"package in R,the heterogeneity,overall sensitivity,specificity,and diagnostic odds ratio were calculated.Moreover,funnel plots were used to visualize and estimate the publication bias in this study.The area under the summary receiver operating characteristic(SROC)curve was computed to display the diagnostic efficiency of DCE-MRI.Results:In the present meta-analysis,a total of 11 studies covering 616 patients were included.The results showed that the pooled sensitivity,specificity,and diagnostic odds ratio were 0.792(95%confidence interval[CI]0.707-0.857),0.779(95%CI 0.715-0.832),and 16.219(97.5%CI 9.123-28.833),respectively.The value of the area under the SROC curve was 0.846.In addition,the SROC curve showed high sensitivities(>0.6)and low false positive rates(<0.5)from most of the included studies,which suggest that the results of our study were reliable.Furthermore,the funnel plot suggested the existence of publication bias.Conclusions:While the DCE-MRI is not the perfect diagnostic tool for distinguishing glioma recurrence and pseudoprogression,it was capable of improving diagnostic accuracy.Hence,further investigations combining DCE-MRI with other imaging modalities are required to establish an efficient diagnostic method for glioma patients.展开更多
文摘BACKGROUND Biliary adenofibroma(BF)is a rare benign epithelial tumor with the possibility of malignant transformation.Its main pathological feature is a well-defined cystic or honeycomb mass.BF has no specific clinical manifestations or laboratory and imaging findings;thus,it is easily misdiagnosed before surgery.This report describes a case in which biliary cystadenoma was misdiagnosed preoperatively and BF was diagnosed postoperatively.The imaging features,particularly the magnetic resonance imaging(MRI)features,were analyzed and summarized.CASE SUMMARY A 68-year-old Chinese man was admitted to our hospital with a 2-mo history of abdominal discomfort.Following admission to our hospital,laboratory examinations showed normal tumor marker concentrations and liver function.Hepatocellular carcinoma was considered after contrast-enhanced ultrasound examination.MRI suggested the possibility of cystadenoma of the bile duct.However,postoperative pathological examination confirmed the diagnosis of BF.No local recurrence was found 1 mo after surgery.CONCLUSION Our objective is to highlight the imaging diagnostic value of BF,especially on an MRI enhanced scan with gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid.
文摘Background:It is crucial to differentiate accurately glioma recurrence and pseudoprogression which have entirely different prognosis and require different treatment strategies.This study aimed to assess the diagnostic accuracy of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)as a tool for distinguishing glioma recurrence and pseudoprogression.Methods:According to particular criteria of inclusion and exclusion,related studies up to May 1,2019,were thoroughly searched from several databases including PubMed,Embase,Cochrane Library,and Chinese biomedical databases.The quality assessment of diagnostic accuracy studies was applied to evaluate the quality of the included studies.By using the"mada"package in R,the heterogeneity,overall sensitivity,specificity,and diagnostic odds ratio were calculated.Moreover,funnel plots were used to visualize and estimate the publication bias in this study.The area under the summary receiver operating characteristic(SROC)curve was computed to display the diagnostic efficiency of DCE-MRI.Results:In the present meta-analysis,a total of 11 studies covering 616 patients were included.The results showed that the pooled sensitivity,specificity,and diagnostic odds ratio were 0.792(95%confidence interval[CI]0.707-0.857),0.779(95%CI 0.715-0.832),and 16.219(97.5%CI 9.123-28.833),respectively.The value of the area under the SROC curve was 0.846.In addition,the SROC curve showed high sensitivities(>0.6)and low false positive rates(<0.5)from most of the included studies,which suggest that the results of our study were reliable.Furthermore,the funnel plot suggested the existence of publication bias.Conclusions:While the DCE-MRI is not the perfect diagnostic tool for distinguishing glioma recurrence and pseudoprogression,it was capable of improving diagnostic accuracy.Hence,further investigations combining DCE-MRI with other imaging modalities are required to establish an efficient diagnostic method for glioma patients.
