Ocular manifestations and quality of life in patients after hematopoietic stem cell transplantation

AIM:To explore the relationship between ocular and systemic conditions and the impact of ocular complications on the quality of life(QOL)in patients after allogeneic hematopoietic stem cell transplantation(ALLO-HSCT).METHODS:Forty-four patients with severe hematopoietic disease were enrolled after ALLO-HSCT at our center from July 2018 to October 2020.They completed two questionnaires:the Ocular Surface Disease Index(OSDI)and the quality-of-life scale for Chinese patients with visual impairment(SQOL-DV1).Ocular conditions and systemic conditions were also assessed.RESULTS:Eye damage was correlated with total bilirubin(P=0.005),and gamma-glutamyl transferase(GGT)(P=0.021).There was no significant correlation between the overall QOL score and OSDI(P=0.8226)or SQOLDV1(P=0.9526)scores.The OSDI and the overall QOL score were not correlated with ocular conditions,including best-corrected visual acuity(BCVA),intraocular pressure,Schirmer tear test II,sodium fluorescein staining,tear film breakup time,and tear meniscus height.SQOLDV1 was correlated with BCVA(P=0.0007),sodium fluorescein staining(P=0.007),and tear film breakup time(P=0.0146).CONCLUSION:In some patients,early ocular symptoms are not evident after ALLO-HSCT,while ocular surface complications can be observed after a comprehensive ophthalmological examination.Especially for those with elevated total bilirubin or GGT,regular ophthalmic follow-up visits are essential to diagnose and treat ocular graft versus host disease(o GVHD),especially for patients with elevated total bilirubin or GGT.

Effect of artificial tribological layer on sliding wear behavior of H13 steel

An artificial tribological layer was formed on the worn surface during sliding,through supplying MoS_2,Fe_2O_3 or their equiponderant mixtures onto the sliding interface of H13/GCr15 steels.The effect of this tribological layer on the wear behavior of H13 steel was studied.The worn surfaces and subsurfaces of H13 steel were thoroughly characterized by using X-ray diffraction（XRD）,scanning electron microscopy（SEM）and energy dispersive spectrometry（EDS）;the wear mechanisms were explored.The research results demonstrated that tribological layer did not exist during sliding of H13 steel with no additive,but it formed with the addition of MoS_2,Fe_2O_3 or their equiponderant mixtures.When there was no tribological layer,the wear rate rapidly increased with an increase of the load.In this case,adhesive and abrasive wear prevailed.As the additives were supplied,the artificial tribological layer was observed to be immediately formed and stably existed on worn surfaces.This tribological layer presented an obvious protective function from wear and friction.Hence,the wear rate and friction coefficient were significantly decreased.MoS_2 as tribological layer seemed to present more obvious protective function than Fe_2O_3.By supplying their mixture,the artificial tribological layer possessed not only the load-carrying capacity of Fe_2O_3,but also the lubricative capacity of MoS_2.These two simultaneous capacities could improve the friction and wear properties of H13 steel further.

Microstructure and deuterium resistance of Al_(2)O_(3)/Y_(2)O_(3) composite coating with different annealing atmospheres

The Al_(2)O_(3)/Y_(2)O_(3) composite coating with a total thickness of 320 nm was prepared by radio-frequency magnetron sputtering.The annealing treatments in three different atmosphere,Ar gas,H;and vacuum,were performed in order to study the influence of microstructure on the deuterium resistance of the coating.