Objective To assess the effectiveness, side effects, and acceptability of copper uterine cavity - shaped intrauterine devices （UCD） with and without indomethacin. Methods We used electronic search and hand search to...Objective To assess the effectiveness, side effects, and acceptability of copper uterine cavity - shaped intrauterine devices （UCD） with and without indomethacin. Methods We used electronic search and hand search to identify relevant literatures. Included papers were systematically reviewed according to previous established guidelines. Results A total of 39 related papers were identified. Of them, 9papers were included in this review： 4 associated with medicated or non-medicated UCD200 （containing copper 200 mm^2） and 5 associated with medicated or non-medicated UCD300 （containing copper 300 mm^2）. The contraceptive effectiveness, cumulative one-year and two-year continuation rates＇ were similar between medicated UCD200, non-medicated UCD200 and TCu220C. The effectiveness of non-medicated UCD300 was similar to that of TCu220C and TCu200. The effectiveness of medicated UCD300 was similar to that of MLCu375 and TCu220C but lower than that of TCu38OA. The cumulative one-year, three-year and five-year continuation rates were similar between medicated, non-medicated UCD300 and TCu380A or MLCu375. The problem of bleeding was less common among medicated UCD users than among non-medicated devices. Conclusions Uterine cavity-shaped devices should continue to be used in the National Family Planning Proramme. However, priority should be given to the 300 mm^2 copper containing device. A large multicenter randomized comparative trial of UCD300 and TCu380A is needed.展开更多
文摘Objective To assess the effectiveness, side effects, and acceptability of copper uterine cavity - shaped intrauterine devices （UCD） with and without indomethacin. Methods We used electronic search and hand search to identify relevant literatures. Included papers were systematically reviewed according to previous established guidelines. Results A total of 39 related papers were identified. Of them, 9papers were included in this review： 4 associated with medicated or non-medicated UCD200 （containing copper 200 mm^2） and 5 associated with medicated or non-medicated UCD300 （containing copper 300 mm^2）. The contraceptive effectiveness, cumulative one-year and two-year continuation rates＇ were similar between medicated UCD200, non-medicated UCD200 and TCu220C. The effectiveness of non-medicated UCD300 was similar to that of TCu220C and TCu200. The effectiveness of medicated UCD300 was similar to that of MLCu375 and TCu220C but lower than that of TCu38OA. The cumulative one-year, three-year and five-year continuation rates were similar between medicated, non-medicated UCD300 and TCu380A or MLCu375. The problem of bleeding was less common among medicated UCD users than among non-medicated devices. Conclusions Uterine cavity-shaped devices should continue to be used in the National Family Planning Proramme. However, priority should be given to the 300 mm^2 copper containing device. A large multicenter randomized comparative trial of UCD300 and TCu380A is needed.
