In a recent publication in Cell,Li et al.reported that inhibiting the spliceosome in human pluripotent stem cells(hPSCs)can induce a stable totipotent state.1 This study signifies the importance of post-transcriptiona...In a recent publication in Cell,Li et al.reported that inhibiting the spliceosome in human pluripotent stem cells(hPSCs)can induce a stable totipotent state.1 This study signifies the importance of post-transcriptional regulation in controlling developmental potential and provides a powerful model system for studying the process of human pre-implantation development in vitro.展开更多
基金K.-P.K.acknowledges support from the Korean Fund for Regenerative Medicine(KFRM)grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Health&Welfare)(22A0203L1)J.K.acknowledges support from the German Research Council(DFG,Project 496710327)Federal Ministry for Education and Research(BMBF)with the grant number 03ZU1202FA.
文摘In a recent publication in Cell,Li et al.reported that inhibiting the spliceosome in human pluripotent stem cells(hPSCs)can induce a stable totipotent state.1 This study signifies the importance of post-transcriptional regulation in controlling developmental potential and provides a powerful model system for studying the process of human pre-implantation development in vitro.
