In this study,using mesoporous silica for the solubility enhancement of poorly watersoluble drug was investigated.Although the incorporating drug into mesoporous silica is generally performed through the solvent meth...In this study,using mesoporous silica for the solubility enhancement of poorly watersoluble drug was investigated.Although the incorporating drug into mesoporous silica is generally performed through the solvent method,the new melting method was proposed in the present study.Fenofibrate,a poorly water-soluble drug,was incorporated into mesoporous silica by solvent method and melting method.The obtained samples were observed by SEM and their physicochemical properties were evaluated by PXRD and DSC measurement.The dissolution and supersaturated property were also investigated.The results from SEM,PXRD and DSC measurement showed that drug could be loaded into pore via the melting method as well as by the solvent method.The drug loaded quantity depended on the pore volume.Drug up to 33%could be incorporated into mesoporous silica and existed in amorphous state.When drug was overloaded or difficulty in incorporation into pore was found,recrystallization of drug occurred at the outer surface of mesoporous silica.From the dissolution test,samples prepared by solvent method and melting method gave the supersaturated drug concentration which sample from melting method showed superior dissolution to the one from solvent method.From this study,drug was efficiently incorporated into mesoporous silica by the melting method which is a simple and solvent-free process,and the aqueous solubility enhancement of poorly watersoluble drug was achieved.展开更多
Aminoalkyl methacrylate copolymer,Eudragit?E PO(EPO),has been used as a polymeric carrier for solid dispersion to significantly enhance the drug dissolution.However,the improvement of the drug dissolution by the drug/...Aminoalkyl methacrylate copolymer,Eudragit?E PO(EPO),has been used as a polymeric carrier for solid dispersion to significantly enhance the drug dissolution.However,the improvement of the drug dissolution by the drug/EPO solid dispersion is limited only in acidic solution due to the pHdependant solubility of basic EPO with its tertiary amino group.We previously reported that the blending of saccharin(SAC)in the drug/EPO solid dispersion led to the supersaturation formation of drug even at neutral pH[1].展开更多
Liposomes, closed vesicles composed of lipid bilayers, have been widely used as pharmaceutical carriers. Liposomal formulations containing doxorubicin (DOX) of an anticancer drug are developed to reduce toxic side eff...Liposomes, closed vesicles composed of lipid bilayers, have been widely used as pharmaceutical carriers. Liposomal formulations containing doxorubicin (DOX) of an anticancer drug are developed to reduce toxic side effects and to improve drug accumulation at tumor tissues. An encapsulation of DOX into the inner water phase of liposomes results in the formations of fibrous DOX bundles and the elongation of the liposomes [1].In this study, atomic force microscopy (AFM).展开更多
文摘In this study,using mesoporous silica for the solubility enhancement of poorly watersoluble drug was investigated.Although the incorporating drug into mesoporous silica is generally performed through the solvent method,the new melting method was proposed in the present study.Fenofibrate,a poorly water-soluble drug,was incorporated into mesoporous silica by solvent method and melting method.The obtained samples were observed by SEM and their physicochemical properties were evaluated by PXRD and DSC measurement.The dissolution and supersaturated property were also investigated.The results from SEM,PXRD and DSC measurement showed that drug could be loaded into pore via the melting method as well as by the solvent method.The drug loaded quantity depended on the pore volume.Drug up to 33%could be incorporated into mesoporous silica and existed in amorphous state.When drug was overloaded or difficulty in incorporation into pore was found,recrystallization of drug occurred at the outer surface of mesoporous silica.From the dissolution test,samples prepared by solvent method and melting method gave the supersaturated drug concentration which sample from melting method showed superior dissolution to the one from solvent method.From this study,drug was efficiently incorporated into mesoporous silica by the melting method which is a simple and solvent-free process,and the aqueous solubility enhancement of poorly watersoluble drug was achieved.
文摘Aminoalkyl methacrylate copolymer,Eudragit?E PO(EPO),has been used as a polymeric carrier for solid dispersion to significantly enhance the drug dissolution.However,the improvement of the drug dissolution by the drug/EPO solid dispersion is limited only in acidic solution due to the pHdependant solubility of basic EPO with its tertiary amino group.We previously reported that the blending of saccharin(SAC)in the drug/EPO solid dispersion led to the supersaturation formation of drug even at neutral pH[1].
文摘Liposomes, closed vesicles composed of lipid bilayers, have been widely used as pharmaceutical carriers. Liposomal formulations containing doxorubicin (DOX) of an anticancer drug are developed to reduce toxic side effects and to improve drug accumulation at tumor tissues. An encapsulation of DOX into the inner water phase of liposomes results in the formations of fibrous DOX bundles and the elongation of the liposomes [1].In this study, atomic force microscopy (AFM).
