期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Role of endoscopic vacuum therapy in the management of gastrointestinal transmural defects 被引量:7
1
作者 Diogo Turiani Hourneaux de Moura Bruna Furia Buzetti Hourneaux de Moura +5 位作者 Michael A Manfredi kelly e hathorn Ahmad N Bazarbashi Igor Braga Ribeiro eduardo Guimaraes Hourneaux de Moura Christopher C Thompson 《World Journal of Gastrointestinal Endoscopy》 CAS 2019年第5期329-344,共16页
A gastrointestinal(GI) transmural defect is defined as total rupture of the GI wall,and these defects can be divided into three categories: perforations,leaks,and fistulas. Surgical management of these defects is usua... A gastrointestinal(GI) transmural defect is defined as total rupture of the GI wall,and these defects can be divided into three categories: perforations,leaks,and fistulas. Surgical management of these defects is usually challenging and may be associated with high morbidity and mortality rates. Recently,several novel endoscopic techniques have been developed,and endoscopy has become a firstline approach for therapy of these conditions. The use of endoscopic vacuum therapy(EVT) is increasing with favorable results. This technique involves endoscopic placement of a sponge connected to a nasogastric tube into the defect cavity or lumen. This promotes healing via five mechanisms,including macrodeformation,microdeformation,changes in perfusion,exudate control,and bacterial clearance,which is similar to the mechanisms in which skin wounds are treated with commonly employed wound vacuums. EVT can be used in the upper GI tract,small bowel,biliopancreatic regions,and lower GI tract,with variable success rates and a satisfactory safety profile. In this article,we review and discuss the mechanism of action,materials,techniques,efficacy,and safety of EVT in the management of patients with GI transmural defects. 展开更多
关键词 GASTROINTESTINAL ENDOSCOPY Endoscopic vacuum therapy Negative pressure therapy FISTULA LEAK PERFORATION Defect
下载PDF
Role of gastroesophageal reflux disease in lung transplantation 被引量:8
2
作者 kelly e hathorn Walter W Chan Wai-Kit Lo 《World Journal of Transplantation》 2017年第2期103-116,共14页
Lung transplantation is one of the highest risk solid organ transplant modalities. Recent studies have demonstrated a relationship between gastroesophageal reflux disease(GERD) and lung transplant outcomes, including ... Lung transplantation is one of the highest risk solid organ transplant modalities. Recent studies have demonstrated a relationship between gastroesophageal reflux disease(GERD) and lung transplant outcomes, including acute and chronic rejection. The aim of this review is to discuss the pathophysiology, evaluation, and management of GERD in lung transplantation, as informed by the most recent publications in the field. The pathophysiology of reflux-induced lung injury includes the effects of aspiration and local immunomodulation in the development of pulmonary decline and histologic rejection, as reflective of allograft injury. Modalities of reflux and esophageal assessment, including ambulatory p H testing, impedance, and esophageal manometry, are discussed, as well as timing of these evaluations relative to transplantation. Finally, antireflux treatments are reviewed, including medical acid suppression and surgical fundoplication, as well as the safety, efficacy, and timing of such treatments relative to transplantation. Our review of the data supports an association between GERD and allograft injury, encouraging a strategy of early diagnosis and aggressive reflux management in lung transplant recipients to improve transplant outcomes. Further studies are needed to explore additional objective measures of reflux and aspiration, better compare medical and surgical antireflux treatment options, extend followup times to capture longer-term clinical outcomes, and investigate newer interventions including minimally invasive surgery and advanced endoscopic techniques. 展开更多
关键词 Lung TRANSPLANT REFLUX ASPIRATION Rejection BRONCHIOLITIS OBLITERANS syndrome FUNDOPLICATION
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部