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Targeting neuroinflammation after therapeutic hypothermia for perinatal hypoxic-ischemic brain injury
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作者 kelly q.zhou Joanne O.Davidson 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第6期1261-1262,共2页
Hypoxic-ischemic encephalopathy(HIE)has an incidence of 1-3 in 1000 term births in high-income countries(Zhou et al.,2020).The standard treatment for these infants is therapeutic hypothermia.Although therapeutic hypot... Hypoxic-ischemic encephalopathy(HIE)has an incidence of 1-3 in 1000 term births in high-income countries(Zhou et al.,2020).The standard treatment for these infants is therapeutic hypothermia.Although therapeutic hypothermia significantly reduces the risk of death and disability for infants with HIE,it is still only partially protective as up to 45%of infants still develop disability despite treatment(Zhou et al.,2020).The current therapeutic hypothermia protocol is optimal for widespread use in infants with moderate to severe HIE.However,it is possible that a more tailored approach for individual babies,including stratification of the cooling regimen for the severity of HIE and the identification of reliable biomarkers to guide treatment,may improve efficacy in the future. 展开更多
关键词 THERAPEUTIC INFLAMMATION protective
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