The treatment of metastatic colorectal cancer by chemotherapy alone was considered palliative and without the potential to cure patients unless patients were rendered resectable.We report two patients with metastatic ...The treatment of metastatic colorectal cancer by chemotherapy alone was considered palliative and without the potential to cure patients unless patients were rendered resectable.We report two patients with metastatic colorectal cancer involving the liver who were considered inoperable andwere treated with systemic chemotherapy using biomodulated 5-fluorouracil.Both patients received 5-fluorouracil and N-(phosphonoacetyl)-l-aspartic acid;one also received methotrexate,leucovorin,and triacetyluridine with the N-(phosphonoacetyl)-l-aspartic acid and 5-fluorouracil.Both patients had a complete remission with chemotherapy and are still alive with no evidence of cancer ten years after the diagnosis of unresectable metastatic disease.These patients provide evidence that prolonged survival can be achieved with systemic chemotherapy without the use of surgery or other forms of local therapy.These patients also confirm the importance of continued investigation of fluorouracil modulating agents,which may further enhance the recent progress made with fluorouracil-based combination chemo-therapy for colorectal cancer.展开更多
文摘The treatment of metastatic colorectal cancer by chemotherapy alone was considered palliative and without the potential to cure patients unless patients were rendered resectable.We report two patients with metastatic colorectal cancer involving the liver who were considered inoperable andwere treated with systemic chemotherapy using biomodulated 5-fluorouracil.Both patients received 5-fluorouracil and N-(phosphonoacetyl)-l-aspartic acid;one also received methotrexate,leucovorin,and triacetyluridine with the N-(phosphonoacetyl)-l-aspartic acid and 5-fluorouracil.Both patients had a complete remission with chemotherapy and are still alive with no evidence of cancer ten years after the diagnosis of unresectable metastatic disease.These patients provide evidence that prolonged survival can be achieved with systemic chemotherapy without the use of surgery or other forms of local therapy.These patients also confirm the importance of continued investigation of fluorouracil modulating agents,which may further enhance the recent progress made with fluorouracil-based combination chemo-therapy for colorectal cancer.
