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A new risk assessment method for evaluation of oxidative chemicals using catalase mutant mouse primary hepatocytes
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作者 Da-Hong Wang Yasuo Ishikawa +5 位作者 Masahiro Miyazaki Hirofumi Fujita ken tsutsui Kuniaki Sano Noriyoshi Masuoka Keiki Ogino 《Health》 2011年第5期288-291,共4页
We examined the possibility of developing a new risk assessment method for potentially hazardous chemicals by using mouse primary hepatocytes from acatalasemic mice (Csb) and the wild-type (Csa) as predictive model. C... We examined the possibility of developing a new risk assessment method for potentially hazardous chemicals by using mouse primary hepatocytes from acatalasemic mice (Csb) and the wild-type (Csa) as predictive model. Chemical-induced cytotoxicities, such as hydrogen peroxide and lawsone, a main hair dye ingredient of henna, were examined. We observed the differences in cell survival between the Csa and Csb in a dose-dependant manner after treatment with either hydrogen peroxide or lawsone, supporting the usefulness of this newly established method for hazard identification of oxidative chemicals in a risk assessment process. More chemicals will be tested to confirm the usefulness of this method for the preliminary screening of oxidative chemicals before animal experimentation. 展开更多
关键词 Catalase-Mutant Mouse HEPATOCYTES Reactive Oxygen Species Hydrogen PEROXIDE Hazard Assessment LAWSONE CYTOTOXICITY
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