基金We thank Dr Ramin Shiekhattar (Wistar Institute, USA) for the baculoviruses expressing Flag-LSD1 and Drs Jianguo Song and Degui Chen (Shanghai Institute of Biochemistry and Cell Biol- ogy, China) for anti-HDAC1 antibody and H3K36me2 antibody, respectively. This study was partially supported by grants from the National Natural Science Foundation of China (90919025, 30871381), the Ministry of Science and Technology of China (2009CB918402, 2009CB825601) and the Research Platform for Cell Signaling Networks from the Science and Technology Com- mission of Shanghai Municipality (06DZ22923).