Systems using numerous cameras are emerging in many fields due to their ease of production and reduced cost, and one of the fields where they are expected to be used more actively in the near future is in image-based ...Systems using numerous cameras are emerging in many fields due to their ease of production and reduced cost, and one of the fields where they are expected to be used more actively in the near future is in image-based rendering （IBR）. Color correction between views is necessary to use multi-view systems in IBR to make audiences feel comfortable when views are switched or when a free viewpoint video is displayed. Color correction usually involves two steps： the first is to adjust camera parameters such as gain, brightness, and aperture before capture, and the second is to modify captured videos through image processing. This paper deals with the latter, which does not need a color pattern board. The proposed method uses scale invariant feature transform （SIFT） to detect correspondences, treats RGB channels independently, calculates lookup tables with an energy-minimization approach, and corrects captured video with these tables. The experimental results reveal that this approach works well.展开更多
Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex.type oligosaccharide attached to Asn297 of the Fc is essen- tial...Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex.type oligosaccharide attached to Asn297 of the Fc is essen- tial for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that gen- erate structural heterogeneity （glycoforms） exhibit unique biological activities. Hence, efficient and quan- titative glycan analysis techniques have been increas- ingly important for the development and quality control of therapeutic antibodies, and g｜ycan profiles of the Fc are recognized as critical quality attributes. In the past decade our understanding of the influence of glycosy- lation on the structure/function of IgG-Fc has grown rapidly through X-ray crystallographic and nuclear magnetic resonance studies, which provides possibili- ties for the design of novel antibody therapeutics. Fur- thermore, the chemoenzymatic glycoengineering approach using endoglycosidase-based glycosyn- thases may facilitate the development of homogeneous IgG glycoforms with desirable functionality as next- generation therapeutic antibodies. Thus, the Fc glycans are fertile ground for the improvement of the safety,functionality, and efficacy of therapeutic IgG antibodies in the era of precision medicine.展开更多
In this paper, some preliminary calculations and the experiments were performed to figure out the flow field, in which some rods were normally inserted into the main flow surrounded by a porous cavity. As a result, it...In this paper, some preliminary calculations and the experiments were performed to figure out the flow field, in which some rods were normally inserted into the main flow surrounded by a porous cavity. As a result, it is found that the starting shock wave severely interacts with the rods, the bow shock wave, its reflections, and the porous wall, which are numerically well predicted at some conditions. Moreover, inserting the rods makes the pressure on the upper wall in the porous region increase when the main flow in the porous region is completely supersonic. The calculations also suggest that three rods cause the widest suction area.展开更多
文摘Systems using numerous cameras are emerging in many fields due to their ease of production and reduced cost, and one of the fields where they are expected to be used more actively in the near future is in image-based rendering （IBR）. Color correction between views is necessary to use multi-view systems in IBR to make audiences feel comfortable when views are switched or when a free viewpoint video is displayed. Color correction usually involves two steps： the first is to adjust camera parameters such as gain, brightness, and aperture before capture, and the second is to modify captured videos through image processing. This paper deals with the latter, which does not need a color pattern board. The proposed method uses scale invariant feature transform （SIFT） to detect correspondences, treats RGB channels independently, calculates lookup tables with an energy-minimization approach, and corrects captured video with these tables. The experimental results reveal that this approach works well.
文摘Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex.type oligosaccharide attached to Asn297 of the Fc is essen- tial for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that gen- erate structural heterogeneity （glycoforms） exhibit unique biological activities. Hence, efficient and quan- titative glycan analysis techniques have been increas- ingly important for the development and quality control of therapeutic antibodies, and g｜ycan profiles of the Fc are recognized as critical quality attributes. In the past decade our understanding of the influence of glycosy- lation on the structure/function of IgG-Fc has grown rapidly through X-ray crystallographic and nuclear magnetic resonance studies, which provides possibili- ties for the design of novel antibody therapeutics. Fur- thermore, the chemoenzymatic glycoengineering approach using endoglycosidase-based glycosyn- thases may facilitate the development of homogeneous IgG glycoforms with desirable functionality as next- generation therapeutic antibodies. Thus, the Fc glycans are fertile ground for the improvement of the safety,functionality, and efficacy of therapeutic IgG antibodies in the era of precision medicine.
文摘In this paper, some preliminary calculations and the experiments were performed to figure out the flow field, in which some rods were normally inserted into the main flow surrounded by a porous cavity. As a result, it is found that the starting shock wave severely interacts with the rods, the bow shock wave, its reflections, and the porous wall, which are numerically well predicted at some conditions. Moreover, inserting the rods makes the pressure on the upper wall in the porous region increase when the main flow in the porous region is completely supersonic. The calculations also suggest that three rods cause the widest suction area.
