The living body is composed of innumerable fine and complex structures.Although these structures have been studied in the past,a vast amount of information pertaining to them still remains unknown.When attempting to o...The living body is composed of innumerable fine and complex structures.Although these structures have been studied in the past,a vast amount of information pertaining to them still remains unknown.When attempting to observe these ultra-structures,the use of electron microscopy(EM)has become indispensable.However,conventional EM settings are limited to a narrow tissue area,which can bias observations.Recently,new trends in EM research have emerged,enabling coverage of far broader,nano-scale fields of view for two-dimensional wide areas and three-dimensional large volumes.Moreover,cutting-edge bioimage informatics conducted via deep learning has accelerated the quantification of complex morphological bioimages.Taken together,these technological and analytical advances have led to the comprehensive acquisition and quantification of cellular morphology,which now arises as a new omics science termed‘morphomics’.展开更多
基金supported by RIKEN Engineering Network Project,RIKEN Aging Project,the Japan Society for the Promotion of Science(JSPS KAKENHI,18K19766 and 15K16536)Prof.Osafune Memorial Scholarship from the Japanese Society of Microscopythe Strategic Core Technology Advancement Program(Supporting Industry Program,SAPOIN)funded by the Ministry of Economy,Trade and Industry in Japan.
文摘The living body is composed of innumerable fine and complex structures.Although these structures have been studied in the past,a vast amount of information pertaining to them still remains unknown.When attempting to observe these ultra-structures,the use of electron microscopy(EM)has become indispensable.However,conventional EM settings are limited to a narrow tissue area,which can bias observations.Recently,new trends in EM research have emerged,enabling coverage of far broader,nano-scale fields of view for two-dimensional wide areas and three-dimensional large volumes.Moreover,cutting-edge bioimage informatics conducted via deep learning has accelerated the quantification of complex morphological bioimages.Taken together,these technological and analytical advances have led to the comprehensive acquisition and quantification of cellular morphology,which now arises as a new omics science termed‘morphomics’.
