BACKGROUND A gastrointestinal stromal tumor(GIST)is a mesenchymal tumor of the gastrointestinal tract that is most commonly found in the stomach.Recurrence of GISTs mostly occurs in the liver or peritoneum,and in most...BACKGROUND A gastrointestinal stromal tumor(GIST)is a mesenchymal tumor of the gastrointestinal tract that is most commonly found in the stomach.Recurrence of GISTs mostly occurs in the liver or peritoneum,and in most cases,multiple metastases occur.As a solitary peritoneal metastasis is rare,an appropriate treatment strategy has not been established.Here,we report a case of solitary peritoneal metastasis after complete resection of gastric GIST.CASE SUMMARY A 76-year-old woman was diagnosed with stomach GIST and underwent laparoscopic local resection using the CLEAN-NET method.As the recurrence risk was intermediate,adjuvant imatinib therapy was not administered.Two years after surgery,routine computed tomography revealed an abdominal mass between the dorsal side of the right hepatic lobe and right kidney.Other imaging tests did not reveal any abnormalities.Laparoscopic observation showed that the tumor was located at the retroperitoneum,and intraperitoneal dissemination was not found.Therefore,we performed laparoscopic tumor resection.Immunohistochemically,the tumor was positive for c-kit and CD34 and had a relatively high mitotic index and MIB-1 Labeling index.We administered adjuvant imatinib therapy.There was no evidence of recurrence 3 years after the operation.CONCLUSION This is the first reported case of a solitary recurrence of GIST in the peritoneum treated with complete laparoscopic resection.展开更多
文摘BACKGROUND A gastrointestinal stromal tumor(GIST)is a mesenchymal tumor of the gastrointestinal tract that is most commonly found in the stomach.Recurrence of GISTs mostly occurs in the liver or peritoneum,and in most cases,multiple metastases occur.As a solitary peritoneal metastasis is rare,an appropriate treatment strategy has not been established.Here,we report a case of solitary peritoneal metastasis after complete resection of gastric GIST.CASE SUMMARY A 76-year-old woman was diagnosed with stomach GIST and underwent laparoscopic local resection using the CLEAN-NET method.As the recurrence risk was intermediate,adjuvant imatinib therapy was not administered.Two years after surgery,routine computed tomography revealed an abdominal mass between the dorsal side of the right hepatic lobe and right kidney.Other imaging tests did not reveal any abnormalities.Laparoscopic observation showed that the tumor was located at the retroperitoneum,and intraperitoneal dissemination was not found.Therefore,we performed laparoscopic tumor resection.Immunohistochemically,the tumor was positive for c-kit and CD34 and had a relatively high mitotic index and MIB-1 Labeling index.We administered adjuvant imatinib therapy.There was no evidence of recurrence 3 years after the operation.CONCLUSION This is the first reported case of a solitary recurrence of GIST in the peritoneum treated with complete laparoscopic resection.
