We investigated the restorative potential of intensive electrical stimulation in a patient with long-standing quadriceps denervation. Stimulation started 1 8 months after injury. After 26 months, the thighs were visib...We investigated the restorative potential of intensive electrical stimulation in a patient with long-standing quadriceps denervation. Stimulation started 1 8 months after injury. After 26 months, the thighs were visibly less wasted. Mus cle cross-sectional areas, measured by computerized tomography, increased from 36.0 cm2 to 57.9 cm2 (right) and from 36.1 cm2 to 52.4 cm2 (left). Knee torque had become sufficient to maintain standing without upper extremity support. Biop sies revealed evidence of both growth and regeneration of myofibers. The results suggest that electrical stimulation may offer a route to the future development of mobility aids in patients with lower motor neuron lesions.展开更多
文摘We investigated the restorative potential of intensive electrical stimulation in a patient with long-standing quadriceps denervation. Stimulation started 1 8 months after injury. After 26 months, the thighs were visibly less wasted. Mus cle cross-sectional areas, measured by computerized tomography, increased from 36.0 cm2 to 57.9 cm2 (right) and from 36.1 cm2 to 52.4 cm2 (left). Knee torque had become sufficient to maintain standing without upper extremity support. Biop sies revealed evidence of both growth and regeneration of myofibers. The results suggest that electrical stimulation may offer a route to the future development of mobility aids in patients with lower motor neuron lesions.
