Oxidative stress and cyclic adenosine 3′,5′-monophosphate(cAMP)/protein kinase A(PKA)pathway in the optic nerve head astrocytes:Glaucoma is a leading cause of blindness worldwide in individuals 60 years of age and o...Oxidative stress and cyclic adenosine 3′,5′-monophosphate(cAMP)/protein kinase A(PKA)pathway in the optic nerve head astrocytes:Glaucoma is a leading cause of blindness worldwide in individuals 60 years of age and older.Despite the widely appreciated disease relevance of structural and functional abnormalities of astrocyte in the optic nerve head(ONH)that is associated with retinal ganglion cell(RGC)axon degeneration,the molecular mechanisms underlying astrocyte dysfunction in glaucomatous ONH degeneration are poorly understood.Oxidative stress is strongly linked to glaucoma pathogenesis,and astrocytes are the responsible cell type that is mostly related to oxidative stress and glaucomatous ONH degeneration.展开更多
This is a complete and exhaustive review on the so-called holographic axion model—a bottom-up holographic system characterized by the presence of a set of shift symmetric scalar bulk fields whose profiles are taken t...This is a complete and exhaustive review on the so-called holographic axion model—a bottom-up holographic system characterized by the presence of a set of shift symmetric scalar bulk fields whose profiles are taken to be linear in the spatial coordinates.This simple model implements the breaking of translational invariance of the dual field theory by retaining the homogeneity of the background geometry and therefore allowing for controllable and fast computations. The usages of this model are very vast and they are a proof of the spectacular versatility of the framework. In this review, we touch upon all the up-to-date aspects of this model from its connection with massive gravity and effective field theories, to its role in modeling momentum dissipation and elastic properties ending with all the phenomenological features and its hydrodynamic description. In summary, this is a complete guide to one of the most used models in Applied Holography and a must-read for any researcher entering this field.展开更多
文摘Oxidative stress and cyclic adenosine 3′,5′-monophosphate(cAMP)/protein kinase A(PKA)pathway in the optic nerve head astrocytes:Glaucoma is a leading cause of blindness worldwide in individuals 60 years of age and older.Despite the widely appreciated disease relevance of structural and functional abnormalities of astrocyte in the optic nerve head(ONH)that is associated with retinal ganglion cell(RGC)axon degeneration,the molecular mechanisms underlying astrocyte dysfunction in glaucomatous ONH degeneration are poorly understood.Oxidative stress is strongly linked to glaucoma pathogenesis,and astrocytes are the responsible cell type that is mostly related to oxidative stress and glaucomatous ONH degeneration.
基金the support of the Shanghai Municipal Science and Technology Major Project (Grant No. 2019SHZDZX01)the Spanish MINECO “Centro de Excelencia Severo Ochoa” Program (Grant No. SEV-2012-0249)+5 种基金supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, Information and Communication Technology (ICT) & Future Planning (Grant No. NRF2017R1A2B4004810)the Gwangju Institute of Science and Technology (GIST) Research Institute (GRI) grant funded by the GIST in 2020supported in part by the National Natural Science Foundation of China (Grant Nos. 12075298, 11991052, and 12047503)supported in part by the National Natural Science Foundation of China (Grant No. 11905024)Dalian University of Technology (Grant No. DUT19LK20)。
文摘This is a complete and exhaustive review on the so-called holographic axion model—a bottom-up holographic system characterized by the presence of a set of shift symmetric scalar bulk fields whose profiles are taken to be linear in the spatial coordinates.This simple model implements the breaking of translational invariance of the dual field theory by retaining the homogeneity of the background geometry and therefore allowing for controllable and fast computations. The usages of this model are very vast and they are a proof of the spectacular versatility of the framework. In this review, we touch upon all the up-to-date aspects of this model from its connection with massive gravity and effective field theories, to its role in modeling momentum dissipation and elastic properties ending with all the phenomenological features and its hydrodynamic description. In summary, this is a complete guide to one of the most used models in Applied Holography and a must-read for any researcher entering this field.
