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二氧化硅纳米颗粒潜在的神经毒性对神经变性疾病的影响
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作者 何柯欣 郭玲 《阿尔茨海默病及相关病杂志》 2024年第2期151-155,共5页
神经变性疾病是一类慢性疾病,包括常见的阿尔茨海默病(Alzheimer’s disease,AD)、帕金森病(parkinson’s disease,PD)和额颞叶痴呆(frontotemporal dementia,FTD)等。这些疾病的病理生理变化特点均有神经元内出现异常蛋白质聚集、氧化... 神经变性疾病是一类慢性疾病,包括常见的阿尔茨海默病(Alzheimer’s disease,AD)、帕金森病(parkinson’s disease,PD)和额颞叶痴呆(frontotemporal dementia,FTD)等。这些疾病的病理生理变化特点均有神经元内出现异常蛋白质聚集、氧化应激反应、线粒体功能障碍等,最终可导致神经元变性死亡。目前虽无彻底治愈这些疾病的特异性疗法,但是不乏可以帮助缓解症状或延缓疾病进展的药物治疗方法。其中,包括二氧化硅纳米颗粒(silica nanoparticles,SiNPs)作为一种新型材料用于神经保护剂作用的疗法。最近的研究表明,这种材料虽有其优点,但可能对神经变性疾病产生负面影响。因此,本文拟以近年相关报道,从SiNPs的暴露途径以及其与神经炎症、线粒体功能障碍、Aβ和p-Tau的临床前研究进行综述,为充分认识SiNPs潜在神经毒性机制研究以及NRDs的防治提供理论或实践依据。 展开更多
关键词 二氧化硅纳米颗粒 神经变性疾病 神经炎症 线粒体功能障碍
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Exploring Apple’s Stock Price Volatility Using Five GARCH Models
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作者 Sihan Fu kexin he +1 位作者 Jialin Li Zheng Tao 《Proceedings of Business and Economic Studies》 2022年第5期137-145,共9页
The financial market is the core of national economic development,and stocks play an important role in the financial market.Analyzing stock prices has become the focus of investors,analysts,and people in related field... The financial market is the core of national economic development,and stocks play an important role in the financial market.Analyzing stock prices has become the focus of investors,analysts,and people in related fields.This paper evaluates the volatility of Apple Inc.(AAPL)returns using five generalized autoregressive conditional heteroskedasticity(GARCH)models:sGARCH with constant mean,GARCH with sstd,GJR-GARCH,AR(1)GJR-GARCH,and GJR-GARCH in mean.The distribution of AAPL’s closing price and earnings data was analyzed,and skewed student t-distribution(sstd)and normal distribution(norm)were used to further compare the data distribution of the five models and capture the shape,skewness,and loglikelihood in Model 4-AR(1)GJR-GARCH.Through further analysis,the results showed that Model 4,AR(1)GJR-GARCH,is the optimal model to describe the volatility of the return series of AAPL.The analysis of the research process is both,a process of exploration and reflection.By analyzing the stock price of AAPL,we reflect on the shortcomings of previous analysis methods,clarify the purpose of the experiment,and identify the optimal analysis model. 展开更多
关键词 Financial market Stock price VOLATILITY GARCH model
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Prediction of Amazon’s Stock Price Based on ARIMA, XGBoost, and LSTM Models
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作者 Zhe Zhu kexin he 《Proceedings of Business and Economic Studies》 2022年第5期127-136,共10页
Finding the best model to predict the trend of stock prices is an issue that has always garnered attention,and it is also closely related to investors’investment dynamics.Even the commonly used autoregressive integra... Finding the best model to predict the trend of stock prices is an issue that has always garnered attention,and it is also closely related to investors’investment dynamics.Even the commonly used autoregressive integrated moving average(ARIMA),extreme gradient boosting(XGBoost),and long short-term memory(LSTM)have their own advantages and disadvantages.We use mean squared error(MSE)to judge the most suitable model for predicting Amazon’s stock price from many aspects and find that LSTM is the model with the best fitting effect and the closest to the real curve.However,the LSTM model still needs to improve in terms of performance so as to reduce the bias.We anticipate the discovery of more models that are apt for predicting stocks in the future. 展开更多
关键词 AMAZON ARIMA XGBoost LSTM
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具有大电导动态范围和多级电导态的铁电Hf_(0.5)Zr_(0.5)O_(2)栅控突触晶体管 被引量:1
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作者 罗春来 张岩 +11 位作者 帅文韬 贺可心 李明 陶瑞强 陈德扬 樊贞 张斌 周小元 戴吉岩 周国富 陆旭兵 刘俊明 《Science China Materials》 SCIE EI CAS CSCD 2023年第6期2372-2382,共11页
得益于铁电材料的非易失性和快速擦写,铁电突触晶体管(FST)在神经形态计算应用中很有前景.然而,在低能耗下同时实现大电导动态范围(G_(max)/G_(min))和多级有效电导态仍是一个挑战.在此,本文首次提出了由铁电Hf_(0.5)Zr_(0.5)O_(2)(HZO... 得益于铁电材料的非易失性和快速擦写,铁电突触晶体管(FST)在神经形态计算应用中很有前景.然而,在低能耗下同时实现大电导动态范围(G_(max)/G_(min))和多级有效电导态仍是一个挑战.在此,本文首次提出了由铁电Hf_(0.5)Zr_(0.5)O_(2)(HZO)栅介质结合溶液处理的氧化铟(In_(2)O_(3))突触晶体管以解决上述问题.通过精细调控的铁电相以及对铁电体和铁电/半导体界面的电荷注入良好抑制,实现了优异的突触特性.在每个尖峰事件490 fJ的低能耗下,该FST成功模拟了高达101个有效电导状态的长时程增强/抑制(LTP/D),且具有大电导动态范围(G_(max)/G_(min)=32.2)和优异耐久性(>1000个循环).此外,模拟实现了96.5%的手写数字识别准确率,这是现有报道的FST的最高记录.这项工作为开发低成本、高性能和节能的铁电突触晶体管提供了一条新途径. 展开更多
关键词 动态范围 半导体界面 电荷注入 栅介质 氧化铟 非易失性 铁电材料 电突触
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Laser trimming for lithography-free fabrications of MoS_(2)devices
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作者 Yong Xie OnurÇakıroğlu +7 位作者 Wenshuai Hu kexin he Sergio Puebla Thomas Pucher Qinghua Zhao Xiaohua Ma Carmen Munuera Andres Castellanos-Gomez 《Nano Research》 SCIE EI CSCD 2023年第4期5042-5046,共5页
Single-layer MoS_(2)produced by mechanical exfoliation is usually connected to thicker and multilayer regions.We show a facile laser trimming method to insulate single-layer MoS_(2)regions from thicker ones.We demonst... Single-layer MoS_(2)produced by mechanical exfoliation is usually connected to thicker and multilayer regions.We show a facile laser trimming method to insulate single-layer MoS_(2)regions from thicker ones.We demonstrate,through electrical characterization,that the laser trimming method can be used to pattern single-layer MoS_(2)channels with regular geometry and electrically disconnected from the thicker areas.Scanning photocurrent microscope further confirms that in the as-deposited flake(connected to a multilayer area)most of the photocurrent is being generated in the thicker flake region.After laser trimming,scanning photocurrent microscopy shows how only the single-layer MoS_(2)region contributes to the photocurrent generation.The presented method is a direct-write and lithography-free(no need of resist or wet chemicals)alternative to reactive ion etching process to pattern the flakes that can be easily adopted by many research groups fabricating devices with MoS_(2) and similar twodimensional materials. 展开更多
关键词 2D materials transition metal dichalcogenides laser trimming differential reflectance
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