Lagrangian coherent structure analysis on transport of Acetes chinensis along coast of Lianyungang,China

Spatial heterogeneity or“patchiness”of plankton distributions in the ocean has always been an attractive and challenging scientific issue to oceanographers.We focused on the accumulation and dynamic mechanism of the Acetes chinensis in the Lianyungang nearshore licensed fishing area.The Lagrangian frame approaches including the Lagrangian coherent structures theory,Lagrangian residual current,and Lagrangian particle-tracking model were applied to find the transport pathways and aggregation characteristics of Acetes chinensis.There exist some material transport pathways for Acetes chinensis passing through the licensed fishing area,and Acetes chinensis is easy to accumulate in the licensed fishing area.The main mechanism forming this distribution pattern is the local circulation induced by the nonlinear interaction of topography and tidal flow.Both the Lagrangian coherent structure analysis and the particle trajectory tracking indicate that Acetes chinensis in the licensed fishing area come from the nearshore estuary.This work contributed to the adjustment of licensed fishing area and the efficient utilization of fishery resources.

Naringin ameliorates H_(2)O_(2)-induced oxidative damage in cells and prolongs the lifespan of female Drosophila melanogaster via the insulin signaling pathway

Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological properties.In this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying mechanisms.The results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in cells.Meanwhile,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde content.Naringin also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem cells.Moreover,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of lysosomes.Furthermore,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.

Resilience Augmentation in Unmanned Weapon Systems via Multi-Layer Attention Graph Convolutional Neural Networks

The collective Unmanned Weapon System-of-Systems(UWSOS)network represents a fundamental element in modern warfare,characterized by a diverse array of unmanned combat platforms interconnected through hetero-geneous network architectures.Despite its strategic importance,the UWSOS network is highly susceptible to hostile infiltrations,which significantly impede its battlefield recovery capabilities.Existing methods to enhance network resilience predominantly focus on basic graph relationships,neglecting the crucial higher-order dependencies among nodes necessary for capturing multi-hop meta-paths within the UWSOS.To address these limitations,we propose the Enhanced-Resilience Multi-Layer Attention Graph Convolutional Network(E-MAGCN),designed to augment the adaptability of UWSOS.Our approach employs BERT for extracting semantic insights from nodes and edges,thereby refining feature representations by leveraging various node and edge categories.Additionally,E-MAGCN integrates a regularization-based multi-layer attention mechanism and a semantic node fusion algo-rithm within the Graph Convolutional Network(GCN)framework.Through extensive simulation experiments,our model demonstrates an enhancement in resilience performance ranging from 1.2% to 7% over existing algorithms.

Thin NASICON Electrolyte to Realize High Energy Density Solid-State Sodium Metal Battery

The solid-state electrolyte in a solid-state battery acts as an electrons'barrier and an ions'bridge between the two electrodes.As solid-state electrolyte does not store the mobile ions,it is necessary to achieve a thin solid-state electrolyte to reduce the internal resistance and enhance the energy density.In this work,a thin NASICON solid-state electrolyte,with a stoichiometry of Na_(3)Zr_(2)Si_(2)PO_(12),is fabricated by the tape-casting method and its thickness can be easily controlled by the gap between substrate and scraper.The areal-specific resistance and the flexural strength increase with the electrolyte thickness.A solid-state sodium metal battery with 86 pm thick Na_(3)Zr_(2)Si_(2)PO_(12)exhibits a reversible specific capacity of 73-78 mAh g^(-1)with a redox potential of 3.4 V at 0.2 C.This work presents the importance of electrolyte thickness to reduce internal resistance and achieve a high energy density for sodium batteries.

媒介补偿:理论溯源与研究路径

媒介技术的发展迭代让媒介介导的传播愈发具有真实、沉浸等属性,这在一定程度上消融了线上与线下、虚拟与现实的边界,塑造并重构着现实。在媒介使用对现实众多的积极影响中,补偿效应(compensation effect)近年来被学者广泛关注。媒介补偿指的是媒介使用户克服时间、空间、个人特质、行为倾向等限制,弥补在线下活动中难以满足的诉求。结合发展心理学的毕生发展视角,现有的媒介补偿理论与实证研究可以归纳为如下议题:社交媒体使用与社会交往、始成年人移动交友软件与亲密关系发展、移民与远程母职养育、老年人的养老与社会适应等。未来的研究可以拓展发展心理学视角,关注成长窗口期的弱势群体的关键心理问题,结合特定媒介的功能和属性,深入挖掘媒介补偿的手段和途径,探讨媒介补偿的机制,推动研究成果的应用。

Nitrogen-Doped Carbon-Encased Bimetallic Selenide for High-Performance Water Electrolysis

Demand of highly efficient earth-abundant transition metal-based electrocatalysts to replace noble metal materials for boosting oxygen evolution reaction(OER)is rapidly growing.Herein,an electrochemically exfoliated graphite(EG)foil supported bimetallic selenide encased in N-doped carbon(EG/(Co,Ni)Se2-NC)hybrid is developed and synthesized by a vapor-phase hydrothermal strategy and subsequent selenization process.The as-prepared EG/(Co,Ni)Se2-NC hybrid exhibits a core-shell structure where the particle diameter of(Co,Ni)Se2 core is about 70 nm and the thickness of N-doped carbon shell is approximately 5 nm.Benefitting from the synergistic effects between the combination of highly active Co species and improved electron transfer from Ni species,and N-doped carbon,the EG/(Co,Ni)Se2-NC hybrid shows remarkable electrocatalytic activity toward OER with a comparatively low overpotential of 258 mV at an current density of 10 mA cm?2 and a small Tafel slope of 73.3 mV dec?1.The excellent OER catalysis performance of EG/(Co,Ni)Se2-NC hybrid is much better than that of commercial Ir/C(343 mV at 10 mA cm?2 and 98.1 mV dec?1),and even almost the best among all previously reported binary CoNi selenide-based OER electrocatalysts.Furthermore,in situ electrochemical Raman spectroscopy combined with ex situ X-ray photoelectron spectroscopy analysis indicates that the superb OER catalysis activity can be attributed to the highly active Co-OOH species and modified electron transfer process from Ni element.

Monitoring microenvironment of Hep G2 cell apoptosis using two-photon fluorescence lifetime imaging microscopy

Apoptosis is very important for the maintenance of cellular homeostasis and is closely related to the occurrence and treatment of many diseases.Mitochondria in cells play a crucial role in programmed cell death and redox processes.Nicotinamide adenine dinucleotide(NAD(P)H)is the primary producer of energy in mitochondria,changing NAD(P)H can directly reflect the physiological state of mitochondria.Therefore,NAD(P)H can be used to evaluate metabolic response.In this paper,we propose a noninvasive detection method that uses two-photon fluorescence lifetime imaging microscopy(TP-FLIM)to characterize apoptosis by observing the binding kinetics of cellular endogenous NAD(P)H.The result shows that the average fluorescence lifetime of NAD(P)H and the fluorescence lifetime of protein-bound NAD(P)H will be affected by the changing pH,serum content,and oxygen concentration in the cell culture environment,and by the treatment with reagents such as H2O2 and paclitaxel.Taxol(PTX).This noninvasive detection method realized the dynamic detection of cellular endogenous substances and the assessment of apoptosis.

Heterogeneous expression of Osa-MIR156bc increases abiotic stress resistance and forage quality of alfalfa

Alfalfa (Medicago sativa L.) is the most widely cultivated perennial leguminous forage crop woldwide.Micro RNA156 (miR156) precursor genes from dicotyledonous species are reportedly useful for improving alfalfa plant architecture and abiotic stress resistance.However,there has been no report on whether a miR156 precursor gene from a monocotyledonous species functions in alfalfa.We introduced two tandem precursor genes of miR156,rice Osa-MIR156b and Osa-MIR156c (Osa-MIR156bc),into alfalfa.The expression of miR156 in the transgenic (TG) alfalfa was significantly elevated.Compared to wild-type plants,the TG plants overexpressing miR156 had more branches and leaves and showed improved salt and drought tolerance.Overexpression of miR156 slightly reduced plant height,but the biomass yield of TG plants grown in flowerpots was still increased.Forage quality of TG plants was markedly improved by reduction of acid detergent lignin (ADL) content and increase in crude protein content.The expression of the putative miR156 target genes Ms SPL6,Ms SPL12,and Ms SPL13 in TG plants was repressed by miR156overexpression,and that of all tested Ms SPLs would be sharply increased under drought or salt stress.RNA sequencing revealed that overexpression of miR156 affected the expression of genes associated with abiotic stress resistance and plant development in multiple pathways.This first report of overexpression of monocot miR156 precursors in alfalfa sheds light on the function of mi RNA156 precursors from the monocot species rice that could be used for genetic improvement of the dicot forage crop alfalfa.

人格因素如何影响知识在组织内的传播:基于社会网络分析的视角

知识分享是重要的人际传播和组织传播的过程。以往研究已阐明人格特质在组织背景下对知识分享行为的影响,但大多是通过整体方式而非通过调查特定的成对人员的方式来探究知识分享。由于知识分享涉及多种对象和渠道,本研究从社会网络分析的视角出发,研究团队内人格与知识分享网络中心度(出度和入度)之间的关系。本研究把知识划分为新知识、一般知识以及技能知识。研究结果表明:人格各维度与新知识分享网络中心度无关,宜人性与一般知识和技能知识分享网络的出度及入度正相关,责任心与一般知识和技能知识分享网络出度正相关,神经质与技能知识分享网络出度负相关。文章同时从促进知识分享的角度对团队建设给出建议,并对未来研究方向进行了讨论。

Adaptive Evolution of the Ventral Scale Microornamentations among Three Snake Species

Research on the ecological effect of microronamentations on the scale surface in reptiles has been carried out over the past few decades.It is found that the microornamentation pattern in reptiles is related to their habitats.This study examined the wettability on scale surface,as well as the differences in microornamentation on ventral scales from the mid-body region in three snake species,Hypsiscopus plumbea(aquatic),Oocatochus rufodorsata(semi-aquatic) and Elaphe carinata(terricolous).Moreover,the scale specimens were metallized and analyzed using scanning electron microscopy.Our results showed that there are microornamentations on the ventral scale surfaces of the tested species,which showed interspecific differences.To be specific,the aquatic snake shows the narrow,fine and regular denticulations which are connected to reduce friction and dirt shedding.By contrast,the terrestrial snake acquired the wider and shorter denticulation which would render more friction during locomotion but it shows greater water resistance to improve the capacity of dirt shedding and compensate for the disadvantage of short and wide denticulations.Additionally,the denticulation characteristics of the semi-aquatic snake fell in between those of aquatic and terrestrial snakes.Therefore,it is deduced in this study that the ventral scale microornamentations in snakes contribute to ecological adaptation to their preferential microhabitats.

Exploration and Consideration of the Development of Sino-foreign Cooperation of Higher Education——A Comparative Analysis Perspective Based on the Data of Municipal Universities of Wuhan, Hubei Province and China

With the tide of economic globalization and the practice of“One Belt and One Road”Initiative,Sino-foreign cooperation has gradually become one of the effective ways to improve the quality of higher education.This paper based on the statistics and analysis of the data released by the Ministry of Education’s foreign-related supervision information platform,combining with the actual investigation and research on the situation of Sino-foreign cooperation of higher education in municipal universities of Wuhan,has found that the Sino-foreign cooperation programs commonly have problems of non-standardized enrollment of students,insufficient quality of teachers and teaching qualities,and lack of core competitiveness.Therefore,it is essential to upgrade the level of foreign cooperative institutions and the standards of students’recruitment,optimize the curriculum,pay attention to the public welfare of education,improve the teaching model,improve the level of teachers,so as to truly realize the original intention of Sino-foreign cooperation in municipal universities of Wuhan.

The Research of the Development of the Hubei Manufacturing Enterprises in SME Board

As in recent years the deepening reform and opening-up and the accelerated economic development of Hubei region as well as the vigorously advocate of the government for innovation and enterpreneurship,small and medium-sized manufacturing enterprises have already becoming a nucleus of pushing the rapid economic development in Hubei.This paper explores the whole development status of the Hubei Manufacturing Enterprises in SME Board through the analysis of eight aspects of the 186 Hubei Manufacturing Enterprises in SME Board Regularly Operated and Annual Report Disclosure in 2017,which finds out that currently Hubei Manufacturing Enterprises in SME Board concentrate to the developed region,the overall education background of the employees is low and most of the enterprises are private enterprises with labor-intensive economy,the financial situation reflects the characteristics of industry differences.Enterprises should accelerate upgrading and transformation,enhancing the market competitive ability,at the same time the government should carefully study,formulating encouraging and supporting policies suitable for different enterprises and industries,strengthening supervision and management of SME board market in order to attract more outstanding small and medium-sized manufacturing enterprises,accelerating the development of manufacturing industry in Hubei.

Iterative multi-photon adaptive compensation technique for deep tissue two-photon fluorescence lifetime imaging

Fluorescence lifetime imaging can reveal the high-resolution structure of various biophysical and chemical parameters in a microenvironment quantitatively.However,the depth of imaging is generally limited to hundreds of micrometers due to aberration and light scattering in biological tissues.This paper introduces an iterative multi-photon adaptive compensation technique(IMPACT)into a two-photon fluorescence lifetime microscopy system to successfully overcome aberrations and multiple scattering problems in deep tissues.It shows that 400 correction modes can be achieved within 5 min,which was mainly limited by the frame rate of a spatial light modulator.This system was used for high-resolution imaging of mice brain tissue and live zebrafish,further verifying its superior performance in imaging quality and photon accumulation speed.

Trace Element Compositions of Pyrite from the Shuangwang Gold Breccias,Western Qinling Orogen,China:Implications for Deep Ore Prediction

The Shuangwang gold deposit, located in the Fengxian-Taibai fore-arc basin in the western Qinling Orogen of Central China, has yielded over 70 tons of gold. It is an orogenic gold deposit occurring in an NW-trending breccia belt. Most of the ores are hydrothermal breccia type containing fragments of adjacent strata cemented by ankerite and pyrite. Pyrite is the most abundant metallic mineral and the major gold-bearing mineral in the ores. A total of 58 pyrite samples from main ore bodies of the Shuangwang gold deposit have been analysed for 44 trace elements by HR-ICP-MS. Sb, Ba, Cu, Pb, Zn, Bi, Mo, Co are selected as indicator elements to investigate the potential usefulness of trace elements in pyrite as an indicator in gold exploration. The results show that the supra-ore halo elements Sb and Ba, which may have been more active than other near-ore halo elements and sub-ore halo elements, are best to characterize the shape of ore bodies. Five target areas are pointed out for deep ore exploration based on a comprehensive study of supra-ore, near-ore and sub-ore halos. This study provides evidence that trace elements in pyrite can be used to depict the deep extension of ore bodies and to vector towards undiscovered ore bodies.

水稻叶绿素含量QTL定位与候选基因表达分析

水稻(Oryza sativa)是我国主要粮食作物之一。提高水稻叶片叶绿素含量,进而提高其光合作用效率是实现高产稳产的重要途径之一。该研究以父系籼稻品种华占(HZ)、母系粳稻品种热研2号(Nekken2)及其构建的120个重组自交系(RILs)为实验材料,在分蘖期和成熟期分别对亲本及其后代剑叶的叶绿素含量(SPAD值)进行测定,同时基于已构建的高密度遗传连锁图谱进行QTL定位。结果共挖掘到20个与叶绿素含量相关的QTLs(分蘖期7个,成熟期13个),LOD值最高达4.77。利用qRT-PCR方法检测QTL区间内与叶绿素含量相关的候选基因的表达,发现LOC_Os06g11780、LOC_Os06g12360、LOC_Os06g39716、LOC_Os08g42610、LOC_Os02g18500、LOC_Os03g21240、LOC_Os03g21400、LOC_Os03g21780、LOC_Os03g30950及LOC_Os03g40550基因的表达量在双亲间差异显著。结合基因表达量及亲本叶绿素表型数据,推测LOC_Os06g11780、LOC_Os06g12360和LOC_Os08g42610的高表达极大地提高了水稻叶绿素含量,进而有效提高植物光合产能。研究结果为筛选和培育高光能利用效率的水稻新品种提供了有利的遗传资源,并为揭示水稻叶绿素含量的动态变化规律及分子调控机制奠定了重要基础。

基于KAP理论的石家庄市区居民用药风险调查研究

调查石家庄市区居民用药知识、态度、行为(KAP)现状,分析用药过程中存在的潜在风险和影响因素,为开展公众安全用药教育提供参考依据。本样本采用线上问卷法对石家庄市区居民用药现状进行调查,用单因素方差分析、T检验、Logistic回归分析影响KAP的因素,同时采用Spearman相关分析对其相关性进行统计。结果表明居民用药的知识、态度和行为分别为(110.4±18.3)分、(39.0±12.2)分和(91.3±11.5)分。Logistic回归结果表明,年龄、受教育程度、职业是影响用药知识的主要因素,受教育程度、职业是影响用药态度的主要因素,用药行为主要受性别、年龄的影响。随着年龄增长,居民用药知识和用药行为水平均有所提高,36–65岁年龄段知识水平较高。男性用药知识、态度、行为均低于女性,非医药卫生行业、受教育程度低是居民用药知识匮乏、用药态度较差的重要因素。居民用药知识和行为的相关系数为0.331(P<0.01)。总之,石家庄市区居民安全用药的KAP现状总体为中等水平,需加强重点高危人群(个别年龄段、受教育程度低、非医药卫生行业、男性)的用药教育,以促进安全、合理用药。

Stafne骨腔10例:从影像分析到诊疗思路

目的探讨Stafne骨腔(SBC)的疾病来源、临床特点、影像学诊断方式及治疗方案,以减少临床中对SBC的漏诊和误诊。方法回顾性分析2018年2月至2022年10月青岛大学附属医院口腔颌面外科就诊的10例SBC病例的临床表现、影像学特点及治疗方案,采用随机数字表法选取同期拍摄CBCT的年龄相仿、位置相近、形态相似,并经病理确诊为下颌骨根尖囊肿的患者10例,采用SPSS 22.0统计软件进行统计分析,对SBC与下颌根尖囊肿在锥形束计算机体层摄影术(CBCT)中灰度值(HU值)的大小进行比较,结合文献分析、总结其可能的病因及临床诊疗思路。结果根据临床表现及影像学检查结果,10例确诊为SBC的患者中,9例位于下颌骨体后部、1例位于下颌升支。10例患者均无疼痛、肿胀和生理功能异常等表现,遂未行治疗,密切随访。SBC与下颌根尖囊肿的HU值之间差异具有统计学意义[HUSBC=-86(-113,-78),HU根尖囊肿=19(-12,37),Z=-3.311,P<0.001]。结论SBC是一种相对罕见的发生于下颌骨的骨腔,因其位置和影像学的特殊性,临床上应高度重视,并结合相应检查方式来减少误诊和漏诊的发生,其中CBCT中的HU值大小可作为一种辅助判别SBC的手段。

Multifunctional magnesium organic framework-based photothermal and pH dual-responsive mouthguard for caries prevention and tooth self-healing promotion

Caries is considered to be the most prevalent non-communicable disease in humans, mainly deriving from acidogenic bacterial biofilm and resulting in the demineralization and decomposition of hard dental tissue. Herein, a composite responsive foam brace loaded with magnesium organic framework (MPC) is designed for caries prevention and tooth remineralization. MPC can intelligently release organic antibacterial molecules (gallic acid) and mineralized ions (Mg2+, Ca2+ and PO43 ) under acidic conditions (pH < 5.5) of biofilm infection, regulating pH and killing bacteria. Additionally, due to the excellent photothermal conversion efficiency, MPC can further enhance the destruction of bacterial biofilm by inhibiting virulence genes and destroying bacterial adhesion under near-infrared light irradiation (808 nm). More importantly, MPC can not only reverse the cariogenic environment at both pH and microbial levels, but also promote self-healing of demineralized teeth in terms of both the micro-structure and mechanical properties.

Electric vehicle adoption delivers public health and environmental benefits

Large-scale electric vehicle(EV)deployment powered by renewable electricity has the potential to drastically change the environmental impacts of road transportation.The transportation sector is a major contributor to global greenhouse gas(GHG)emissions[1,2],air pollution,and related health impacts[3].Renewable-powered EVs substantially decrease fossil fuel consumption and are a pivotal technology to reduce transportation’s climate burden while also substantially improving air quality and public health.However.

水稻叶片水势的QTL定位与候选基因分析

为探究叶片水势(LWP)相关基因在水稻(Oryzasativa)抗旱中的作用及其遗传机制,以热研2号(Nekken2)和华占(HZ)为亲本以及构建的120个重组自交系(RILs)群体为实验材料,对水稻分蘖期叶片水势进行检测,并利用前期基于高通量测序构建的分子遗传连锁图谱进行数量性状基因座(QTL)分析。结果表明,共检测到5个与水稻分蘖期叶片水势相关的QTLs,分别位于第2、3、4、11和12号染色体上,LOD值均达2.5以上,其中位于4号染色体物理距离24066261–30847136 bp内QTL的LOD值高达5.15。对这些QTL区间内与水势相关的候选基因进行定量分析,发现LOCOs02g56630、LOCOs02g57720、LOCOs02g57580、LOCOs04g43730、LOCOs04g46490、LOCOs04g44570和LOCOs04g44060这7个基因在双亲间表达量差异显著。位于4号染色体QTL区间内LOCOs04g46490基因的表达在两亲本间存在显著差异。对基因LOCOs04g46490进行测序分析,发现该基因在两亲本间共存在6处差异,从而导致氨基酸序列的改变。通过QTL挖掘及相关基因表达分析,发现这些基因与水稻叶片水势调控相关,可能间接影响水稻的抗旱性。检测到的QTL位点对水势相关基因精细定位和克隆具有重要参考价值,有助于进一步理解水稻叶片水势的遗传基础,并为培育耐旱水稻新品种提供有利的基因资源。