With the development of nanomedicine,nanomaterials have been widely used,offering specific drug delivery to target sites,minimal side effects,and significant therapeutic effects.The kidneys have filtration and reabsor...With the development of nanomedicine,nanomaterials have been widely used,offering specific drug delivery to target sites,minimal side effects,and significant therapeutic effects.The kidneys have filtration and reabsorption functions,with various potential target cell types and a complex structural environment,making the strategies for kidney function protection and recovery after injury complex.This also lays the foundation for the application of nanomedicine in kidney diseases.Currently,evidence in preclinical and clinical settings supports the feasibility of targeted therapy for kidney diseases using drug delivery based on nanomaterials.The prerequisite for nanomedicine in treating kidney diseases is the use of carriers with good biocompatibility,including nanoparticles,hydrogels,liposomes,micelles,dendrimer polymers,adenoviruses,lysozymes,and elastin-like polypeptides.These carriers have precise renal uptake,longer half-life,and targeted organ distribution,protecting and improving the efficacy of the drugs they carry.Additionally,attention should also be paid to the toxicity and solubility of the carriers.While the carriers mentioned above have been used in preclinical studies for targeted therapy of kidney diseases both in vivo and in vitro,extensive clinical trials are still needed to ensure the short-term and long-term effects of nano drugs in the human body.This review will discuss the advantages and limitations of nanoscale drug carrier materials in treating kidney diseases,provide a more comprehensive catalog of nanocarrier materials,and offer prospects for their drug-loading efficacy and clinical applications.展开更多
基金supported by Beijing Hospitals Authority Clinical medicine Development of special funding support (ZLRK202308)National High Level Hospital Clinical Research Funding (2023-NHLHCRF-YS-01)+8 种基金Elite Medical Professionals Project of China-Japan Friendship Hospital (ZRJY2023-GG06)the China Postdoctoral Science Foundation (2023M733986 and 2023T160741)Cross-sectional project of China-Japan Friendship Hospital (2023-HX-JC-10 and 2023-HX-103)International Association of Chinese Nephrologists Research Grant (No.IACNRG-01)the Open Grant from the Pingyuan Laboratory (2023PY-OP-0203)Young Elite Scientists Sponsorship Program by CAST (2023QNRC001 and 2022QNRC001)Beijing Natural Science Foundation (7244407)Independent innovation science fund for young scholar (QNFC034)National Natural Science Foundation (82274327).
文摘With the development of nanomedicine,nanomaterials have been widely used,offering specific drug delivery to target sites,minimal side effects,and significant therapeutic effects.The kidneys have filtration and reabsorption functions,with various potential target cell types and a complex structural environment,making the strategies for kidney function protection and recovery after injury complex.This also lays the foundation for the application of nanomedicine in kidney diseases.Currently,evidence in preclinical and clinical settings supports the feasibility of targeted therapy for kidney diseases using drug delivery based on nanomaterials.The prerequisite for nanomedicine in treating kidney diseases is the use of carriers with good biocompatibility,including nanoparticles,hydrogels,liposomes,micelles,dendrimer polymers,adenoviruses,lysozymes,and elastin-like polypeptides.These carriers have precise renal uptake,longer half-life,and targeted organ distribution,protecting and improving the efficacy of the drugs they carry.Additionally,attention should also be paid to the toxicity and solubility of the carriers.While the carriers mentioned above have been used in preclinical studies for targeted therapy of kidney diseases both in vivo and in vitro,extensive clinical trials are still needed to ensure the short-term and long-term effects of nano drugs in the human body.This review will discuss the advantages and limitations of nanoscale drug carrier materials in treating kidney diseases,provide a more comprehensive catalog of nanocarrier materials,and offer prospects for their drug-loading efficacy and clinical applications.
