Digestive side effects associated with interferon and ribavirin in the treatme nt of chronic hepatitis C seem to be non specific.So far, inflammatory bowel dis eases have only been rarely described in this context. We...Digestive side effects associated with interferon and ribavirin in the treatme nt of chronic hepatitis C seem to be non specific.So far, inflammatory bowel dis eases have only been rarely described in this context. We report two cases of Cr ohn’s disease which occurred a few months after inter- feron and ribavirin treatment for chronic hepatitis C. The first case was a 43 year old man treated for 7 months with a interferon and ribavirin combination f or chronic hepatitis C who experienced colitis related to Crohn’s disease, with the occurrence of articular and cutaneous manifestations. The second case was a 43 year old women treated for 8 months with a pegylated interferon and ribaviri n combination for chronic hepatitis C who developed Crohn’s disease with right ileo-colic topography and severe evolution requiring an ileo-coecal resection because of the failure of medical treatment. The alpha interferon used for its a ntiviral action against hepatitis C virus, has complex immunomodulationeffects w hich could reveal latent Crohn’s disease.展开更多
文摘Digestive side effects associated with interferon and ribavirin in the treatme nt of chronic hepatitis C seem to be non specific.So far, inflammatory bowel dis eases have only been rarely described in this context. We report two cases of Cr ohn’s disease which occurred a few months after inter- feron and ribavirin treatment for chronic hepatitis C. The first case was a 43 year old man treated for 7 months with a interferon and ribavirin combination f or chronic hepatitis C who experienced colitis related to Crohn’s disease, with the occurrence of articular and cutaneous manifestations. The second case was a 43 year old women treated for 8 months with a pegylated interferon and ribaviri n combination for chronic hepatitis C who developed Crohn’s disease with right ileo-colic topography and severe evolution requiring an ileo-coecal resection because of the failure of medical treatment. The alpha interferon used for its a ntiviral action against hepatitis C virus, has complex immunomodulationeffects w hich could reveal latent Crohn’s disease.
