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Primary Extra-Gastrointestinal Stromal Tumors (E-GIST) of the Liver, about Two Cases and Review of the Literature Oncology Hospital Experience at Chu Hassan II in FES
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作者 Oumaima Siyouri Mohammed ismaili +8 位作者 khaoula alaoui ismaili Imane Stitou Hajar Medyouni Jihane Chouef Lamiae Amaadour Karima Oualla Zineb Benbrahim Samia Arifi Nawfel Mellas 《Journal of Cancer Therapy》 CAS 2023年第3期117-126,共10页
Introduction: Primary extra-gastrointestinal stromal tumors (E-GIST) of the liver are rare. The clinical presentation can range from asymptomatic to bleeding or manifestations of mass effect. Cancer surgery followed b... Introduction: Primary extra-gastrointestinal stromal tumors (E-GIST) of the liver are rare. The clinical presentation can range from asymptomatic to bleeding or manifestations of mass effect. Cancer surgery followed by adjuvant treatment with imatinib is the standard of care. However, in special circumstances, a cytoreductive approach may represent a therapeutic option. We describe here the case of two patients who presented with a painful and protruding epigastric mass, the first case was a localized E-GIST candidate for neoadjuvant treatment with imatinib with complete resection surgery thereafter with very good evolution, and the second is that of an E-GIST of the liver at an advanced stage with an evolution very quick to death. Conclusion: Primary liver E-GIST is a rare condition. Treatment is based on systemic therapy and total resection surgery. However, cytoreductive surgery will be required when complete resection is not possible. 展开更多
关键词 Extra GIST Foie IMATINIB
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Pre-Sacral Chordomas, about Two Cases and Review of the Literature
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作者 Oumaima Siyouri khaoula alaoui ismaili +8 位作者 Imane Stitou Mohammed ismaili Hajar Medyouni Jihane Chouef Lamiae Amaadour Karima Oualla Zineb Benbrahim Samia Arifi Nawfel Mellas 《Journal of Cancer Therapy》 CAS 2023年第4期152-160,共9页
The World Health Organization (WHO) defines chordoma as a malignant tumor of intermediate or low grade, developing at the expense of embryonic remnants of the notochord. These tumors represent 8.4% of all malignant bo... The World Health Organization (WHO) defines chordoma as a malignant tumor of intermediate or low grade, developing at the expense of embryonic remnants of the notochord. These tumors represent 8.4% of all malignant bone tumors. We report 2 cases collected in the medical oncology department at the CHU Hassan II in Fes. In whom the clinical examination revealed a mass and/or signs of loco-regional compression. The tumor was located in the sacrum in both patients. The diagnosis was based on the data of the anatomopathological examination showing the association of a lobulated architecture with classic physaliphore cells and a mucoid intercellular substance. Immunohistochemistry was performed for both patients. The principle of therapeutic management was based on radiotherapy and targeted therapy since surgery was difficult given the local tumor extension. 展开更多
关键词 Chordomas IMATINIB RADIOTHERAPY
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