Metastatic apocrine sweat gland adenocarcinoma in a terrier dog

This report describes the clinical and pathological aspects of an apocrine sweat gland carcinoma with distant metastasis in an aged dog.A 7-year-old male terrier dog was referred to small animal hospital of Shuhid Bahonar University of Kerman with a 5.5×3.5 centimeter pedunculated mass on its head near left auricular region which had been progressively growing since tliree months ago.The radiography showed no local and distant metastasis.Surgical excision and histological evaluation was done.Histologically,the mass was composed of epithelial cells arranged in glandular and solid patterns.The morphologic findings suggested either a primary or metastatic apocrine-gland carcinoma.Immunohistochemically,the tumor cells were intensely positive for cytokeratin 7 and 20 and negative for S100 protein.On the basis of histopathological and clinical findings,the tumor was diagnosed as a malignant apocrine gland tumor,arising from apocrine sweat glands of the skin.Local tumor recurrence with anorexia and weight loss was reported by the owner nine month later.Severe submandibular and prescapular lymphadenomegaly was noted in clinical examination.Several large pulmonary nodules were noted in chest radiographs resembling mediastinal lymph node metastasis.Second surgery and chemotherapy was rejected by the owner due to grave prognosis of the patient.The animal was died 45 days later due to respiratory complications.Tumors of apocrine sweat glands are relatively uncommon in dogs whereas apocrine gland adenocarcinoma with distant metastasis is extremely rare.

Clinical and pathological findings of concurrent poxvirus lesions and aspergillosis infection in canaries

Objective:To investigate clinical,pathological and mycological findings in canaries,in which pox lesions and Aspergillus fumigatus(A.fumigatus)infection were observed simultaneously.Methods:This study was performed on a breeding colony(about 100 canaries)affected by fatal wasting disease.Necropsy was undertaken on 10 severely affected canaries,and gross lesions were recorded.Samples from internal organs displaying lesions were obtained for histopathological evaluation.Tracheal swap samples of internal organs of the all infected animals with lesions at necropsy were cultured in Sabouraud Dextrose Agar for mycological examination.Results:At necropsy,caseous foci were determined in the lungs,on the air sacs,liver,spleen,heart.Swelling of the eyelids,diffuse hemorrhages in the subcutaneous tissue with small papular lesions of the skin were other typical necropsy findings.Histopathologically,pathognomonic eosinophilic intracytoplasmic inclusion bodies,which called Bollinger bodies,in both skin cells and vacuolated air way epithelial cells confirmed canary pox infection.Moreover,histopathological examination of the white-yellowish caseous foci revealed necrotic granulomatous reaction consisting of macrophages,heterophil leukocytes and giant cells encapsulated with a fibrous tissue.After the culture of the tissue samples,the formation of bluish green colonies confirmed A.fumigatus infection.Conclusions:Canary pox has been known as the disease that can result in high losses in a short time,as a re-emerging disease that has not been present during recent years in canary flocks in Iran.So,the current paper provides useful information to prevent misdiagnosed of canary pox disease which can cause secondary mycotic infection.