Thrombosis,a leading cause of cardiovascular morbidity and mortality,involves the formation of blood clots within blood vessels.Current animal models and in vitro systems have limitations in recapitulating the complex...Thrombosis,a leading cause of cardiovascular morbidity and mortality,involves the formation of blood clots within blood vessels.Current animal models and in vitro systems have limitations in recapitulating the complex human vasculature and hemodynamic conditions,limiting the research in understanding the mechanisms of thrombosis.Bioprinting has emerged as a promising approach to construct biomimetic vascular models that closely mimic the structural and mechanical properties of native blood vessels.This review discusses the key considerations for designing bioprinted vascular conduits for thrombosis studies,including the incorporation of key structural,biochemical and mechanical features,the selection of appropriate biomaterials and cell sources,and the challenges and future directions in the field.The advancements in bioprinting techniques,such as multimaterial bioprinting and microfluidic integration,have enabled the development of physiologically relevant models of thrombosis.The future of bioprinted models of thrombosis lies in the integration of patient-specific data,real-time monitoring technologies,and advanced microfluidic platforms,paving the way for personalized medicine and targeted interventions.As the field of bioprinting continues to evolve,these advanced vascular models are expected to play an increasingly important role in unraveling the complexities of thrombosis and improving patient outcomes.The continued advancements in bioprinting technologies and the collaboration between researchers from various disciplines hold great promise for revolutionizing the field of thrombosis research.展开更多
基金supported by the National Health and Medical Research Council(NHMRC)of Australia(APP2003904-L.A.J.)NSW Cardiovascular Capacity Building Program(Early-Mid Career Researcher Grant-L.A.J.,H22/98586-K.L.)+7 种基金MRFF Cardiovascular Health Mission Grants(MRF2016165-L.A.J.,MRF2023977-L.A.J.)MRFF Early to Mid-Career Researchers Grant(MRF2028865-L.A.J.)NSW Government Boosting Business Innovation Program(BBIP)International Stream(L.A.J.)National Heart Foundation Vanguard Grant(106979-L.A.J.)Office of Global and Research Engagement(International Sustainable Development Goal Program-L.A.J.)a Snow Medical Research Foundation Fellow(2022SF176)a National Heart Foundation Future Leader Fellow Level 2(105863)an Australian Research Council Future Fellow(FT230100249).
文摘Thrombosis,a leading cause of cardiovascular morbidity and mortality,involves the formation of blood clots within blood vessels.Current animal models and in vitro systems have limitations in recapitulating the complex human vasculature and hemodynamic conditions,limiting the research in understanding the mechanisms of thrombosis.Bioprinting has emerged as a promising approach to construct biomimetic vascular models that closely mimic the structural and mechanical properties of native blood vessels.This review discusses the key considerations for designing bioprinted vascular conduits for thrombosis studies,including the incorporation of key structural,biochemical and mechanical features,the selection of appropriate biomaterials and cell sources,and the challenges and future directions in the field.The advancements in bioprinting techniques,such as multimaterial bioprinting and microfluidic integration,have enabled the development of physiologically relevant models of thrombosis.The future of bioprinted models of thrombosis lies in the integration of patient-specific data,real-time monitoring technologies,and advanced microfluidic platforms,paving the way for personalized medicine and targeted interventions.As the field of bioprinting continues to evolve,these advanced vascular models are expected to play an increasingly important role in unraveling the complexities of thrombosis and improving patient outcomes.The continued advancements in bioprinting technologies and the collaboration between researchers from various disciplines hold great promise for revolutionizing the field of thrombosis research.
