Objectives.:To evaluate the association between bcl-2 expression,some pathological factors (lymph-vascular space invasion (LVSI),tumor grade,depth of stromal invasion),and tumor recurrence in cervical cancer. Methods....Objectives.:To evaluate the association between bcl-2 expression,some pathological factors (lymph-vascular space invasion (LVSI),tumor grade,depth of stromal invasion),and tumor recurrence in cervical cancer. Methods.:A matched case-control study was performed in cervical cancer patients who underwent radical hysterectomy and were found to have negative lymph node between January 1992 and June 1998 in Bangkok Metropolitan Administration Medical College and Vajira Hospital and Maharaj Nakorn Chiangmai Hospital,Thailand. Cases were 32 patients who had tumor recurrence within 5 years after surgery. Controls were 63 patients who were disease free for at least 5 years after surgery. Cases and controls were matched for age,stage,histology,and tumor size. All except one case,who had only one matching control,had two controls. Paraffin-embedded cervical cancer tissues of cases and controls were immunohistochemical stained for bcl-2. Results.:Bcl-2 positive was demonstrated in 43.7%of tumor from recurrent cases,which was not different from 50.8%from non-recurrent controls (P = 0.378). Tumor grade and LVSI had significant association with tumor recurrence. From multivariable analysis,the patients with grade 2-3 tumors had the odds ratio of 6.9 for recurrence compared to patients with grade 1 tumors. The patients whose tumors had LVSI had the recurrent odds ratio of 5.4 compared to those without LVSI. Conclusions.:There was no association between bcl-2 expression and tumor recurrence in cervical cancer,while tumor grade and LVSI had significant association with tumor recurrence.展开更多
Objective. To evaluate the usefulness of the recently proposed algorithm (Seidman JD, Kurman RJ, Ronnett BM. Primary and metastatic mucinous adenocarcinomas in the ovaries: incidence in routine practice with a new app...Objective. To evaluate the usefulness of the recently proposed algorithm (Seidman JD, Kurman RJ, Ronnett BM. Primary and metastatic mucinous adenocarcinomas in the ovaries: incidence in routine practice with a new approach to improve intraoperative diagnosis. Am J Surg Pathol 2003; 27: 985- 93 [5]) that classifies mucinous adenocarcinomas of the ovary as primary when they were unilateral ≥ 10 cm and as metastatic when they were unilateral < 10 cm or bilateral. Methods. Malignant ovarian neoplasms, which were resected in Chiang Mai University Hospital between 1992 and 2003, were histologically reviewed. Mucinous adenocarcinomas involving the ovary were identified. The medical records and radiologic materials were reviewed in correlation with the pathologic features to identify the primary site. Results. There were 74 cases of mucinous adenocarcinomas; 16 were primary ovarian; 52, metastatic; and 6 of indeterminate primary site (primary versus metastatic). Primary mucinous adenocarcinomas had a mean size of 16.4 cm and bilateral involvement in 13% . Metastatic mucinous adenocarcinomas had a mean size of 11.7 cm and bilateral involvement in 77% . Excluding the 6 tumors of indeterminate primary site, the proposed algorithm correctly classified primary and metastatic tumors in 84% of 68 cases. Of 21 unilateralmucinous adenocarcinomas ≥ 10 cm, 62% were primary ovarian. Of 5 unilateral tumors < 10 cm, 80% were metastatic. Of 42 bilateral mucinous adenocarcinomas, 95% were metastatic. Conclusion. The algorithm provided high accuracy in the overall prediction of primary and metastatic mucinous adenocarcinomas of the ovary,with major strength in the identification of metastatic tumors by bilaterality or size < 10 cm. However, the prediction of primary mucinous adenocarcinomas by unilaterality and size ≥ 10 cm was less reliable than previously reported. Due to the overlapping features between primary and metastatic tumors and the higher frequency of the latter, the possibility of metastases should always be borne in mind in the evaluation of mucinous adenocarcinomas of the ovary.展开更多
文摘Objectives.:To evaluate the association between bcl-2 expression,some pathological factors (lymph-vascular space invasion (LVSI),tumor grade,depth of stromal invasion),and tumor recurrence in cervical cancer. Methods.:A matched case-control study was performed in cervical cancer patients who underwent radical hysterectomy and were found to have negative lymph node between January 1992 and June 1998 in Bangkok Metropolitan Administration Medical College and Vajira Hospital and Maharaj Nakorn Chiangmai Hospital,Thailand. Cases were 32 patients who had tumor recurrence within 5 years after surgery. Controls were 63 patients who were disease free for at least 5 years after surgery. Cases and controls were matched for age,stage,histology,and tumor size. All except one case,who had only one matching control,had two controls. Paraffin-embedded cervical cancer tissues of cases and controls were immunohistochemical stained for bcl-2. Results.:Bcl-2 positive was demonstrated in 43.7%of tumor from recurrent cases,which was not different from 50.8%from non-recurrent controls (P = 0.378). Tumor grade and LVSI had significant association with tumor recurrence. From multivariable analysis,the patients with grade 2-3 tumors had the odds ratio of 6.9 for recurrence compared to patients with grade 1 tumors. The patients whose tumors had LVSI had the recurrent odds ratio of 5.4 compared to those without LVSI. Conclusions.:There was no association between bcl-2 expression and tumor recurrence in cervical cancer,while tumor grade and LVSI had significant association with tumor recurrence.
文摘Objective. To evaluate the usefulness of the recently proposed algorithm (Seidman JD, Kurman RJ, Ronnett BM. Primary and metastatic mucinous adenocarcinomas in the ovaries: incidence in routine practice with a new approach to improve intraoperative diagnosis. Am J Surg Pathol 2003; 27: 985- 93 [5]) that classifies mucinous adenocarcinomas of the ovary as primary when they were unilateral ≥ 10 cm and as metastatic when they were unilateral < 10 cm or bilateral. Methods. Malignant ovarian neoplasms, which were resected in Chiang Mai University Hospital between 1992 and 2003, were histologically reviewed. Mucinous adenocarcinomas involving the ovary were identified. The medical records and radiologic materials were reviewed in correlation with the pathologic features to identify the primary site. Results. There were 74 cases of mucinous adenocarcinomas; 16 were primary ovarian; 52, metastatic; and 6 of indeterminate primary site (primary versus metastatic). Primary mucinous adenocarcinomas had a mean size of 16.4 cm and bilateral involvement in 13% . Metastatic mucinous adenocarcinomas had a mean size of 11.7 cm and bilateral involvement in 77% . Excluding the 6 tumors of indeterminate primary site, the proposed algorithm correctly classified primary and metastatic tumors in 84% of 68 cases. Of 21 unilateralmucinous adenocarcinomas ≥ 10 cm, 62% were primary ovarian. Of 5 unilateral tumors < 10 cm, 80% were metastatic. Of 42 bilateral mucinous adenocarcinomas, 95% were metastatic. Conclusion. The algorithm provided high accuracy in the overall prediction of primary and metastatic mucinous adenocarcinomas of the ovary,with major strength in the identification of metastatic tumors by bilaterality or size < 10 cm. However, the prediction of primary mucinous adenocarcinomas by unilaterality and size ≥ 10 cm was less reliable than previously reported. Due to the overlapping features between primary and metastatic tumors and the higher frequency of the latter, the possibility of metastases should always be borne in mind in the evaluation of mucinous adenocarcinomas of the ovary.
