Plant-derived vesicles(PDVs)are membranous structures that originate from plant cells and are responsible for multiple physiological and pathological functions.In the last decade,PDVs have gained much attention for th...Plant-derived vesicles(PDVs)are membranous structures that originate from plant cells and are responsible for multiple physiological and pathological functions.In the last decade,PDVs have gained much attention for their involvement in different biological processes,including intercellular communication and defense response,and recent scientific evidence has opened a new avenue for their applications in cancer treatment.Nevertheless,much remains unknown about these vesicles,and current research remains inconsistent.This review aims to provide a comprehensive introduction to PDVs,from their biological characteristics to purification methods,and to summarize the status of their potential development for cancer therapy.展开更多
Over thousands of years,natural bioactive compounds derived from plants(bioactive phytocompounds,BPCs)have been used worldwide to address human health issues.Today,they are a significant resource for drug discovery in...Over thousands of years,natural bioactive compounds derived from plants(bioactive phytocompounds,BPCs)have been used worldwide to address human health issues.Today,they are a significant resource for drug discovery in the development of modern medicines.Although many BPCs have promising biological activities,most of them cannot be effectively utilized in drugs for therapeutic applications because of their inherent limitations of low solubility,structural instability,short half-life,poor bioavailability,and non-specific distribution to organs.Researchers have utilized emerging nanoformulation(NF)technologies to overcome these limitations as they have demonstrated great potential to improve the solubility,stability,and pharmacokinetic and pharmacodynamic characteristics of BPCs.This review exemplifies NF strategies for resolving the issues associated with BPCs and summarizes recent advances in their preclinical and clinical applications for imaging and therapy.This review also highlights how innovative NF technologies play a leading role in next-generation BPC-based drug development for extended therapeutic applications.Finally,this review discusses the opportunities to take BPCs with meaningful clinical impact from bench to bedside and extend the patent life of BPC-based medicines with new formulations or application to new adjacent diseases beyond the primary drug indications.展开更多
基金This research was supported by Korea Institute of Science and Technology(KIST)intramural research grant and the Korean Fund for Regenerative Medicine(21A0503L1)of the Korea government(the Ministry of Science and ICT,the Ministry of Health&Welfare).
文摘Plant-derived vesicles(PDVs)are membranous structures that originate from plant cells and are responsible for multiple physiological and pathological functions.In the last decade,PDVs have gained much attention for their involvement in different biological processes,including intercellular communication and defense response,and recent scientific evidence has opened a new avenue for their applications in cancer treatment.Nevertheless,much remains unknown about these vesicles,and current research remains inconsistent.This review aims to provide a comprehensive introduction to PDVs,from their biological characteristics to purification methods,and to summarize the status of their potential development for cancer therapy.
基金supported by Basic Science Research Programs through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(2017R1D1A1B03034888,2021R1A6A3A01086719 and 2015R1A6A3A04059033)a Korea Institute of Science and Technology(KIST)intramural research grant.
文摘Over thousands of years,natural bioactive compounds derived from plants(bioactive phytocompounds,BPCs)have been used worldwide to address human health issues.Today,they are a significant resource for drug discovery in the development of modern medicines.Although many BPCs have promising biological activities,most of them cannot be effectively utilized in drugs for therapeutic applications because of their inherent limitations of low solubility,structural instability,short half-life,poor bioavailability,and non-specific distribution to organs.Researchers have utilized emerging nanoformulation(NF)technologies to overcome these limitations as they have demonstrated great potential to improve the solubility,stability,and pharmacokinetic and pharmacodynamic characteristics of BPCs.This review exemplifies NF strategies for resolving the issues associated with BPCs and summarizes recent advances in their preclinical and clinical applications for imaging and therapy.This review also highlights how innovative NF technologies play a leading role in next-generation BPC-based drug development for extended therapeutic applications.Finally,this review discusses the opportunities to take BPCs with meaningful clinical impact from bench to bedside and extend the patent life of BPC-based medicines with new formulations or application to new adjacent diseases beyond the primary drug indications.
