In a recent study published in Nature,Garcia et al.use a sophisticated approach to identify fitness-enhancing mutations for T cells that was inspired by cancer evolution.1 The identified CARD11-PIK3R3 gene fusion enha...In a recent study published in Nature,Garcia et al.use a sophisticated approach to identify fitness-enhancing mutations for T cells that was inspired by cancer evolution.1 The identified CARD11-PIK3R3 gene fusion enhanced tumor rejection and persistence of engineered T cells in multiple tumor models and might have the potential to improve efficacy of adoptive T-cell therapies in cancer patients.展开更多
基金K.S.is supported by grants from the German Federal Ministry of Education and Research(BMBF,project-IDs 01KI2013 and 031L0290B)the Else Kröner-Fresenius-Stiftung(project-ID 2020_EKEA.127)+4 种基金the German Research Foundation(DFG)through the research training group RTG 2504(project-ID 401821119)the Interdisciplinary Center for Clinical Research of the University Hospital of Erlangen(project-ID A98)the European Union(Yellow4FLAVI consortium,project-ID 101137459)J.R.is supported by grants from the German Research Foundation(DFG)(project-ID 210592381-SFB 1054,project-ID 395357507-SFB 1371,project-ID 369799452-TRR 237,project-ID 452881907-TRR 338,project-ID 435874434-RTG 2668,RU 695/12-1)The Leukemia&Lymphoma Society,and the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation programme(grant agreement No 834154).
文摘In a recent study published in Nature,Garcia et al.use a sophisticated approach to identify fitness-enhancing mutations for T cells that was inspired by cancer evolution.1 The identified CARD11-PIK3R3 gene fusion enhanced tumor rejection and persistence of engineered T cells in multiple tumor models and might have the potential to improve efficacy of adoptive T-cell therapies in cancer patients.
