To investigate ovarian function after heterotopic autotransplantation of human ovarian tissue banked at -196°C. A clinical case study. University medical center. A 37-year-old woman with cervical cancer (stage Ib...To investigate ovarian function after heterotopic autotransplantation of human ovarian tissue banked at -196°C. A clinical case study. University medical center. A 37-year-old woman with cervical cancer (stage Ib). Frozenthawed human ovarian tissue was transplanted to two different heterotopic sites. Ovarian function of the grafts was monitored sequentially by blood sampling for the hormonal profiles and by ultrasound. The hormonal profile remained at the postmenopausal level until 10 weeks after transplantation. By 14 weeks, the return of ovarian function was evidenced by the elevation of the serum E2 level (57.5 pg/mL). While monitoring hormonal profiles every 2 days for 5 weeks, we observed the LH surge (69.8 IU/L) followed by the elevation of the P4 concentration (9.6 ng/mL), suggesting presumptive ovulation. The ultrasound revealed a dominant follicle on the rectus muscle in the abdominal site. However, there was no sign of follicle development in the breast site. Ovarian function ceased around 28 weeks after transplantation. Heterotopic autotransplantation of cryobanked human ovarian tissue can be a practical strategy for restoration of ovarian function after cancer treatment. As a site for transplantation, a space between the rectus sheath and the rectus muscle appeared to be effective.展开更多
The spleen arises from a mesenchymal bulge at the 6-mm stage of development. There are a wide variety of splenic anomalies and variations that range from benign to clinically significant, and this article presents a b...The spleen arises from a mesenchymal bulge at the 6-mm stage of development. There are a wide variety of splenic anomalies and variations that range from benign to clinically significant, and this article presents a brief review of splenic embryology and a case report of an anomalous splenic vein that precluded the formation of a Nissen fundoplication.展开更多
Mucinous cystadenomas of the pancreas are uncommon lesions in adults and even more rare in children. This report presents a case of a pancreatic mucinous cystadenoma in a 1-year-old boy and offers a review of the lite...Mucinous cystadenomas of the pancreas are uncommon lesions in adults and even more rare in children. This report presents a case of a pancreatic mucinous cystadenoma in a 1-year-old boy and offers a review of the literature and discussion of the surgical implications.展开更多
文摘To investigate ovarian function after heterotopic autotransplantation of human ovarian tissue banked at -196°C. A clinical case study. University medical center. A 37-year-old woman with cervical cancer (stage Ib). Frozenthawed human ovarian tissue was transplanted to two different heterotopic sites. Ovarian function of the grafts was monitored sequentially by blood sampling for the hormonal profiles and by ultrasound. The hormonal profile remained at the postmenopausal level until 10 weeks after transplantation. By 14 weeks, the return of ovarian function was evidenced by the elevation of the serum E2 level (57.5 pg/mL). While monitoring hormonal profiles every 2 days for 5 weeks, we observed the LH surge (69.8 IU/L) followed by the elevation of the P4 concentration (9.6 ng/mL), suggesting presumptive ovulation. The ultrasound revealed a dominant follicle on the rectus muscle in the abdominal site. However, there was no sign of follicle development in the breast site. Ovarian function ceased around 28 weeks after transplantation. Heterotopic autotransplantation of cryobanked human ovarian tissue can be a practical strategy for restoration of ovarian function after cancer treatment. As a site for transplantation, a space between the rectus sheath and the rectus muscle appeared to be effective.
文摘The spleen arises from a mesenchymal bulge at the 6-mm stage of development. There are a wide variety of splenic anomalies and variations that range from benign to clinically significant, and this article presents a brief review of splenic embryology and a case report of an anomalous splenic vein that precluded the formation of a Nissen fundoplication.
文摘Mucinous cystadenomas of the pancreas are uncommon lesions in adults and even more rare in children. This report presents a case of a pancreatic mucinous cystadenoma in a 1-year-old boy and offers a review of the literature and discussion of the surgical implications.
