Objective. Syndecan- 1 binds to various extracellular matrix components via its heparan sulfate glycosaminoglycans (HS- GAG) and most of its biological functions are considered to be associated with this process. The ...Objective. Syndecan- 1 binds to various extracellular matrix components via its heparan sulfate glycosaminoglycans (HS- GAG) and most of its biological functions are considered to be associated with this process. The aims of this study are to investigate its expression in cervical neoplasms. Methods. We investigated the expression of both the syndecan- 1 core protein and cell- surface HS- GAG by immunohistochemistry in 53 cervical intraepithelial neoplasm (CIN), 19 microinvasive, 143 invasive cervical cancers, and 29 metastatic lymph node samples, and analyzed correlations with various clinicopathological features. Results. The progression of CIN to early invasive cancer was found to associate with reduced levels of both syndecan- 1 and HS- GAG expression. In squamous cell carcinomas, HS- GAG expression was significantly lower in cases with lymph- vascular space invasion. Additionally, the overall survival rates for patients exhibiting low HS- GAG expression was significantly lower than patients exhibiting high HS- GAG expression (P = 0.019). Low HS- GAG expression in positive nodes was determined to be a disease- free and overall survival prognostic factor (P = 0.028 and P = 0.018, respectively). Conclusion. The loss of syndecan- 1 and HS- GAG expression is an early event in cervical carcinogenesis. The loss of HS- GAG expression particularly in positive nodes can serve as an indicator of aggressive disease potential and poor prognosis in patients with invasive cervical cancer.展开更多
Objective: The purpose of the present study was to identify prognostic factors in surgically treated patients with stage IB- IIB cervical cancers, who also presented with positive pelvic nodes. Method: The patient pop...Objective: The purpose of the present study was to identify prognostic factors in surgically treated patients with stage IB- IIB cervical cancers, who also presented with positive pelvic nodes. Method: The patient population consisted of 68 individuals presenting with stage IB-IIB cervical cancers and with histologically proven pelvic lymph nodes. Result: We found no association between the type of adjuvant therapy and patient outcome. Multivariate analysis revealed that non-squamous histology was an independent prognostic factor for disease-free and overall survival rates. In squamous cell carcinomas, the bilateral nature of the positive nodes was found to be a significant factor for disease-free survival rates. In non-squamous cell carcinomas, positive nodes of more than 2 cm in size were found to be a signi-ficant factor for disease-free survival rates. Conclusion: Non-squamous histology was an independent prognostic factor and chemoradiotherapy did not improve the survival outcomes of the patients in this study population.展开更多
Objective: In this study, we measured both thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels, and then determined the TP/DPD ratios, in a number of invasive cervical cancers. Our aim was to...Objective: In this study, we measured both thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels, and then determined the TP/DPD ratios, in a number of invasive cervical cancers. Our aim was to investigate the association between these values and the clinicopathological features of invasive cervical cancer, including patient prognosis. Study design: Using enzyme-linked immunosorbent assays, the TP and DPD activities were quantitatively measured in 51 patients with cervical cancer who had also undergone a radical hysterectomy. Results: The TP, DPD and TP/DPD values in squamous cell carcinoma (SCC) were found to be significantly higher than the levels in non-SCC. Furthermore, in a SCC subgroup, the TP/DPD levels were significantly higher in cases where parametrial invasion was evident, and in a non-SCC subgroup, these levels were also significantly higher in cases with deep stromal invasion, lymph-vascular space invasion, large tumor size and parametrial invasion. The disease-free survival rate is shown to be significantly higher in patients with low TP/DPD levels indicating that this ratio may be associated with both the progression and recurrence of invasive cervical cancer. Conclusion: TP/DPD ratios may be associated with both the progression and recurrence of invasive cervical cancer.展开更多
Objective: To determine whether patient characteristics and presenting symptoms could be prognostic indicators for endometrial cancer in Japanese women. Methods: Review of the medical charts, which included presenting...Objective: To determine whether patient characteristics and presenting symptoms could be prognostic indicators for endometrial cancer in Japanese women. Methods: Review of the medical charts, which included presenting symptoms and other patient characteristics, of 242 women who underwent surgical treatment for FIGO stage I-IV endometrial cancer. Results: FIGO stage, histologic grade, and lower abdominal pain were found to be significant independent factors for progression-free and overall survival. In contrast, abnormal uterine bleeding, comorbidities, and prior malignancy were not found to be prognostic factors. Conclusion: Lower abdominal pain was found to be an independent prognostic factor in endometrial cancer among Japanese women.展开更多
文摘Objective. Syndecan- 1 binds to various extracellular matrix components via its heparan sulfate glycosaminoglycans (HS- GAG) and most of its biological functions are considered to be associated with this process. The aims of this study are to investigate its expression in cervical neoplasms. Methods. We investigated the expression of both the syndecan- 1 core protein and cell- surface HS- GAG by immunohistochemistry in 53 cervical intraepithelial neoplasm (CIN), 19 microinvasive, 143 invasive cervical cancers, and 29 metastatic lymph node samples, and analyzed correlations with various clinicopathological features. Results. The progression of CIN to early invasive cancer was found to associate with reduced levels of both syndecan- 1 and HS- GAG expression. In squamous cell carcinomas, HS- GAG expression was significantly lower in cases with lymph- vascular space invasion. Additionally, the overall survival rates for patients exhibiting low HS- GAG expression was significantly lower than patients exhibiting high HS- GAG expression (P = 0.019). Low HS- GAG expression in positive nodes was determined to be a disease- free and overall survival prognostic factor (P = 0.028 and P = 0.018, respectively). Conclusion. The loss of syndecan- 1 and HS- GAG expression is an early event in cervical carcinogenesis. The loss of HS- GAG expression particularly in positive nodes can serve as an indicator of aggressive disease potential and poor prognosis in patients with invasive cervical cancer.
文摘Objective: The purpose of the present study was to identify prognostic factors in surgically treated patients with stage IB- IIB cervical cancers, who also presented with positive pelvic nodes. Method: The patient population consisted of 68 individuals presenting with stage IB-IIB cervical cancers and with histologically proven pelvic lymph nodes. Result: We found no association between the type of adjuvant therapy and patient outcome. Multivariate analysis revealed that non-squamous histology was an independent prognostic factor for disease-free and overall survival rates. In squamous cell carcinomas, the bilateral nature of the positive nodes was found to be a significant factor for disease-free survival rates. In non-squamous cell carcinomas, positive nodes of more than 2 cm in size were found to be a signi-ficant factor for disease-free survival rates. Conclusion: Non-squamous histology was an independent prognostic factor and chemoradiotherapy did not improve the survival outcomes of the patients in this study population.
文摘Objective: In this study, we measured both thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) levels, and then determined the TP/DPD ratios, in a number of invasive cervical cancers. Our aim was to investigate the association between these values and the clinicopathological features of invasive cervical cancer, including patient prognosis. Study design: Using enzyme-linked immunosorbent assays, the TP and DPD activities were quantitatively measured in 51 patients with cervical cancer who had also undergone a radical hysterectomy. Results: The TP, DPD and TP/DPD values in squamous cell carcinoma (SCC) were found to be significantly higher than the levels in non-SCC. Furthermore, in a SCC subgroup, the TP/DPD levels were significantly higher in cases where parametrial invasion was evident, and in a non-SCC subgroup, these levels were also significantly higher in cases with deep stromal invasion, lymph-vascular space invasion, large tumor size and parametrial invasion. The disease-free survival rate is shown to be significantly higher in patients with low TP/DPD levels indicating that this ratio may be associated with both the progression and recurrence of invasive cervical cancer. Conclusion: TP/DPD ratios may be associated with both the progression and recurrence of invasive cervical cancer.
文摘Objective: To determine whether patient characteristics and presenting symptoms could be prognostic indicators for endometrial cancer in Japanese women. Methods: Review of the medical charts, which included presenting symptoms and other patient characteristics, of 242 women who underwent surgical treatment for FIGO stage I-IV endometrial cancer. Results: FIGO stage, histologic grade, and lower abdominal pain were found to be significant independent factors for progression-free and overall survival. In contrast, abnormal uterine bleeding, comorbidities, and prior malignancy were not found to be prognostic factors. Conclusion: Lower abdominal pain was found to be an independent prognostic factor in endometrial cancer among Japanese women.
