Hyaluronan is a widely occurring extracellular matrix molecule,which is not only a supporting structural component,but also an active regulator of cellular functions.The chemophysical and biological properties of hyal...Hyaluronan is a widely occurring extracellular matrix molecule,which is not only a supporting structural component,but also an active regulator of cellular functions.The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins,making hyaluronan a fascinating molecule with great functional diversity.This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders,such as atherosclerosis,myocardial infarction,and stroke,with the aim to provide a foundation for future research and clinical trials.展开更多
基金Project supported by the Key Research and Development Program of the Ministry of Science and Technology(No.2017YFC0111902)the Shanghai Natural Science Foundation(No.13ZR1404700),China
文摘Hyaluronan is a widely occurring extracellular matrix molecule,which is not only a supporting structural component,but also an active regulator of cellular functions.The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins,making hyaluronan a fascinating molecule with great functional diversity.This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders,such as atherosclerosis,myocardial infarction,and stroke,with the aim to provide a foundation for future research and clinical trials.
