肺脏肿瘤是一种高发病率、高致死率疾病[1],在发展早期主要依赖NK细胞等淋巴细胞发挥抗肿瘤作用[2],其中CXCR3^(+)NK细胞可依赖CXCL9/10等趋化因子的招募作用[3]而快速迁移,并大量分泌IFN-γ和穿孔素等效应因子,发挥免疫监视等作用[4]...肺脏肿瘤是一种高发病率、高致死率疾病[1],在发展早期主要依赖NK细胞等淋巴细胞发挥抗肿瘤作用[2],其中CXCR3^(+)NK细胞可依赖CXCL9/10等趋化因子的招募作用[3]而快速迁移,并大量分泌IFN-γ和穿孔素等效应因子,发挥免疫监视等作用[4]。桔梗-姜半夏配伍(the combination of Platycodon Grandiflorum and Pinella Ternata,PG+PT)常用于肿瘤的临床治疗中[5]。本研究旨在探讨PG+PT对肺脏肿瘤微环境中NK细胞、特别是CXCR3+NK的免疫药理作用,以明确该配伍发挥抗肿瘤作用的部分药理机制。展开更多
目的分析联合免疫阻断后乙型肝炎病毒(hepatitis B virus,HBV)母婴传播的影响因素,评价母婴阻断效果,为乙肝母婴阻断相关卫生政策与健康干预措施提供依据。方法以海南省2015—2020年住院分娩的HBsAg阳性孕产妇及其分娩的7~12月龄婴儿共1...目的分析联合免疫阻断后乙型肝炎病毒(hepatitis B virus,HBV)母婴传播的影响因素,评价母婴阻断效果,为乙肝母婴阻断相关卫生政策与健康干预措施提供依据。方法以海南省2015—2020年住院分娩的HBsAg阳性孕产妇及其分娩的7~12月龄婴儿共11363对为研究对象,收集孕产妇围产期一般情况、本次妊娠孕产期保健及分娩情况、乙肝标志物检测情况、抗病毒治疗情况、分娩时母婴一般状况以及乙肝母婴传播阻断措施实施情况进行分析。结果海南省2015—2020年住院分娩的HBsAg阳性孕产妇及其所生婴儿11363对,婴儿出生后7~12个月时,检测婴儿HBsAg阳性率为1.47%,不同年份婴儿HBsAg阳性率差异无统计学意义(P>0.05)。不同民族、文化程度、职业、分娩方式、分娩地点、产科操作、会阴裂伤程度和孕产妇是否孕产期异常、婴儿不同性别、是否早产以及是否围产儿异常的孕产妇所生婴儿HBsAg阳性率差异均无统计学意义(均P>0.05),不同年龄段孕产妇所生婴儿HBsAg阳性率差异有统计学意义(P<0.05),低龄孕产妇所生婴儿HBsAg阳性率高于高龄孕产妇。HBeAg阳性孕产妇抗病毒治疗率低,其所生婴儿HBsAg阳性率2.54%高于HBeAg阴性孕产妇所生婴儿HBsAg阳性率0.83%(P<0.05)。结论乙肝疫苗和乙肝免疫球蛋白联合免疫可有效阻断HBV母婴传播,HBsAg阳性妇女可在适龄期生育,对HBeAg阳性孕妇可实施抗病毒治疗以阻断母婴传播,这为乙肝防控策略和措施的制定提供了重要依据。展开更多
Objective： To observe the clinical efficacy of umbilicus application with Chinese medicine in treating children＇s chronic diarrhea due to food intolerance and the value of healthy diet education. Methods： Eighty ki...Objective： To observe the clinical efficacy of umbilicus application with Chinese medicine in treating children＇s chronic diarrhea due to food intolerance and the value of healthy diet education. Methods： Eighty kids with chronic diarrhea due to food intolerance were recruited from multiple centers and divided by using the random number table into a treatment group of 40 cases and a control group of 40 cases. For both groups, based on the level of serum food-specific immunoglobulin G（Ig-G）, the patients were given unified diet following the healthy diet guidance： safe, alternate, and forbidden, while the treatment group was additionally given umbilicus application with Chinese medicine. The therapeutic efficacy and symptom score of traditional Chinese medicine（TCM） were observed and compared respectively after 1-week, 2-week, 4-week, and 12-week treatment. Results： The diarrhea symptoms and coupled symptoms scores dropped significantly in the two groups after treatment（ all P〈0.05）, and the inter-group comparisons also showed statistical significances（P〈0.05）. The total effective rate was 97.5% in the treatment group versus 77.5% in the control group, and the inter-group difference was statistically significant（P〈0.05）. Conclusion： The healthy diet guidance based on the food intolerance test is effective in helping treat diarrhea, while umbilicus application with Chinese medicine works better in treating diarrhea for kids with chronic diarrhea due to food intolerance and can significantly enhance the therapeutic efficacy.展开更多
文摘肺脏肿瘤是一种高发病率、高致死率疾病[1],在发展早期主要依赖NK细胞等淋巴细胞发挥抗肿瘤作用[2],其中CXCR3^(+)NK细胞可依赖CXCL9/10等趋化因子的招募作用[3]而快速迁移,并大量分泌IFN-γ和穿孔素等效应因子,发挥免疫监视等作用[4]。桔梗-姜半夏配伍(the combination of Platycodon Grandiflorum and Pinella Ternata,PG+PT)常用于肿瘤的临床治疗中[5]。本研究旨在探讨PG+PT对肺脏肿瘤微环境中NK细胞、特别是CXCR3+NK的免疫药理作用,以明确该配伍发挥抗肿瘤作用的部分药理机制。
文摘目的分析联合免疫阻断后乙型肝炎病毒(hepatitis B virus,HBV)母婴传播的影响因素,评价母婴阻断效果,为乙肝母婴阻断相关卫生政策与健康干预措施提供依据。方法以海南省2015—2020年住院分娩的HBsAg阳性孕产妇及其分娩的7~12月龄婴儿共11363对为研究对象,收集孕产妇围产期一般情况、本次妊娠孕产期保健及分娩情况、乙肝标志物检测情况、抗病毒治疗情况、分娩时母婴一般状况以及乙肝母婴传播阻断措施实施情况进行分析。结果海南省2015—2020年住院分娩的HBsAg阳性孕产妇及其所生婴儿11363对,婴儿出生后7~12个月时,检测婴儿HBsAg阳性率为1.47%,不同年份婴儿HBsAg阳性率差异无统计学意义(P>0.05)。不同民族、文化程度、职业、分娩方式、分娩地点、产科操作、会阴裂伤程度和孕产妇是否孕产期异常、婴儿不同性别、是否早产以及是否围产儿异常的孕产妇所生婴儿HBsAg阳性率差异均无统计学意义(均P>0.05),不同年龄段孕产妇所生婴儿HBsAg阳性率差异有统计学意义(P<0.05),低龄孕产妇所生婴儿HBsAg阳性率高于高龄孕产妇。HBeAg阳性孕产妇抗病毒治疗率低,其所生婴儿HBsAg阳性率2.54%高于HBeAg阴性孕产妇所生婴儿HBsAg阳性率0.83%(P<0.05)。结论乙肝疫苗和乙肝免疫球蛋白联合免疫可有效阻断HBV母婴传播,HBsAg阳性妇女可在适龄期生育,对HBeAg阳性孕妇可实施抗病毒治疗以阻断母婴传播,这为乙肝防控策略和措施的制定提供了重要依据。
基金supported by the Key Special Program of Science and Technology During the National Twelfth Five-year Plan(No.2012ZX10005004-003)National Natural Science Foundati on of China(No.81302924)+1 种基金Program of Shanghai Science and Technology Committee(No.15401971100)Special Plan of Shanghai Chinese Medicine Experts(No.ZY3-RCPY-3-1027)~~
文摘Objective： To observe the clinical efficacy of umbilicus application with Chinese medicine in treating children＇s chronic diarrhea due to food intolerance and the value of healthy diet education. Methods： Eighty kids with chronic diarrhea due to food intolerance were recruited from multiple centers and divided by using the random number table into a treatment group of 40 cases and a control group of 40 cases. For both groups, based on the level of serum food-specific immunoglobulin G（Ig-G）, the patients were given unified diet following the healthy diet guidance： safe, alternate, and forbidden, while the treatment group was additionally given umbilicus application with Chinese medicine. The therapeutic efficacy and symptom score of traditional Chinese medicine（TCM） were observed and compared respectively after 1-week, 2-week, 4-week, and 12-week treatment. Results： The diarrhea symptoms and coupled symptoms scores dropped significantly in the two groups after treatment（ all P〈0.05）, and the inter-group comparisons also showed statistical significances（P〈0.05）. The total effective rate was 97.5% in the treatment group versus 77.5% in the control group, and the inter-group difference was statistically significant（P〈0.05）. Conclusion： The healthy diet guidance based on the food intolerance test is effective in helping treat diarrhea, while umbilicus application with Chinese medicine works better in treating diarrhea for kids with chronic diarrhea due to food intolerance and can significantly enhance the therapeutic efficacy.
