Although chemoradiotherapy (CRT) is one curative treatment option for patients with esophageal squamous cell carcinoma (ESCC), local failure after CRT remains a major problem for patients’ curability. The aim of this...Although chemoradiotherapy (CRT) is one curative treatment option for patients with esophageal squamous cell carcinoma (ESCC), local failure after CRT remains a major problem for patients’ curability. The aim of this study was to evaluate the efficacy and safety of photodynamic therapy (PDT) as a salvage treatment for local failure. From August 2007 to March 2012, 193 consecutive ESCC patients were treated with definitive CRT in Kyoto University Hospital. Eighteen of the patients with T2 or earlier T-stage local failure after CRT underwent salvage PDT. After the salvage PDT, 11 patients (61.1%) achieved a complete response at the primary site. Over a median follow-up period of 28.3 months, the 1-year survival and progression-free survival rates were 77.8% and 38.9%, respectively;and the 2-year survival and progression-free survival rates were 60.6% and 33.3%, respectively. Adverse events were mild esophageal stricture in seven (38.9%), esophageal obstruction because of necrotic tissue in nine (50.0%), and photosensitivity in three (16.7%) patients. There were no severe complications or treatment-related deaths. Salvage PDT may be a promising treatment option for the patients with a local residual or recurrent tumor after CRT for ESCC when the lesion is suspected to be in T2 or earlier.展开更多
The rotational frequency tone noise emitted from the automobile turbocharger is called the pulsation noise. The cause of the pulsation noise is not fully understood, but is considered to be due to some manufacturing e...The rotational frequency tone noise emitted from the automobile turbocharger is called the pulsation noise. The cause of the pulsation noise is not fully understood, but is considered to be due to some manufacturing errors, which is called the mistuning. The effects of the mistuning of the impeller blade on the noise field inside the flow passage of the compressor are numerically investigated. Here, the flow passage includes the volute and duct located downstream of the compressor impeller. Our numerical approach is found to successfully capture the wavelength of the pulsation noise at given rotational speeds by the comparison with the experiments. One of the significant findings is that the noise field of the pulsation noise in the duct is highly one-dimensional although the flow fields are highly three-dimensional.展开更多
文摘Although chemoradiotherapy (CRT) is one curative treatment option for patients with esophageal squamous cell carcinoma (ESCC), local failure after CRT remains a major problem for patients’ curability. The aim of this study was to evaluate the efficacy and safety of photodynamic therapy (PDT) as a salvage treatment for local failure. From August 2007 to March 2012, 193 consecutive ESCC patients were treated with definitive CRT in Kyoto University Hospital. Eighteen of the patients with T2 or earlier T-stage local failure after CRT underwent salvage PDT. After the salvage PDT, 11 patients (61.1%) achieved a complete response at the primary site. Over a median follow-up period of 28.3 months, the 1-year survival and progression-free survival rates were 77.8% and 38.9%, respectively;and the 2-year survival and progression-free survival rates were 60.6% and 33.3%, respectively. Adverse events were mild esophageal stricture in seven (38.9%), esophageal obstruction because of necrotic tissue in nine (50.0%), and photosensitivity in three (16.7%) patients. There were no severe complications or treatment-related deaths. Salvage PDT may be a promising treatment option for the patients with a local residual or recurrent tumor after CRT for ESCC when the lesion is suspected to be in T2 or earlier.
文摘The rotational frequency tone noise emitted from the automobile turbocharger is called the pulsation noise. The cause of the pulsation noise is not fully understood, but is considered to be due to some manufacturing errors, which is called the mistuning. The effects of the mistuning of the impeller blade on the noise field inside the flow passage of the compressor are numerically investigated. Here, the flow passage includes the volute and duct located downstream of the compressor impeller. Our numerical approach is found to successfully capture the wavelength of the pulsation noise at given rotational speeds by the comparison with the experiments. One of the significant findings is that the noise field of the pulsation noise in the duct is highly one-dimensional although the flow fields are highly three-dimensional.
