Objective. To assess the possibility of quantitative determination of bowel wall vascularity using contrast-enhanced (SonoVue ) wideband harmonic imaging ultrasound and the HDI-Lab software in patients with Crohn’ ...Objective. To assess the possibility of quantitative determination of bowel wall vascularity using contrast-enhanced (SonoVue ) wideband harmonic imaging ultrasound and the HDI-Lab software in patients with Crohn’ s disease. Material andmethods. Twenty-one patients (13 F, 8 M, average age 33.8 ± 12.7 years, range 21-60 years) with histologically confirmed Crohn’ s disease and bowel wall thickness≥ 5mm were recruited for the study. All ultrasound examinations were performed using a Philips HDI 5000 scanner. Bowel wall vascularity was determined at the site of maximum bowel wall thickness at baseline and at 30, 60, 90 and 120 s following application of the contrast enhancer SonoVue (1.2 ml) using the HDI-Lab software. Results. The mean length of bowel segments exhibiting increased wall thickness was 122.3 mm (range: 23-350 ± 74.7 mm), with a mean wall thickness of 7.6 ± 1.2 mm. Onset of echo enhancement secondary to contrast medium application was observed after an average 13.4 s (range 7-19 ± 4.2 s).Echo intensity corresponding to maxi.mum vascularity was measured 30 s after application of contrast medium. Maximum average contrast medium uptake was 217.5% (range 118-466 ± 100.1% ). Conclusions. It is possible to quantify bowel wall vascularity accurately in patients with Crohn’ s disease using contrast-enhanced pulse inversion ultrasound (low-MI).展开更多
文摘Objective. To assess the possibility of quantitative determination of bowel wall vascularity using contrast-enhanced (SonoVue ) wideband harmonic imaging ultrasound and the HDI-Lab software in patients with Crohn’ s disease. Material andmethods. Twenty-one patients (13 F, 8 M, average age 33.8 ± 12.7 years, range 21-60 years) with histologically confirmed Crohn’ s disease and bowel wall thickness≥ 5mm were recruited for the study. All ultrasound examinations were performed using a Philips HDI 5000 scanner. Bowel wall vascularity was determined at the site of maximum bowel wall thickness at baseline and at 30, 60, 90 and 120 s following application of the contrast enhancer SonoVue (1.2 ml) using the HDI-Lab software. Results. The mean length of bowel segments exhibiting increased wall thickness was 122.3 mm (range: 23-350 ± 74.7 mm), with a mean wall thickness of 7.6 ± 1.2 mm. Onset of echo enhancement secondary to contrast medium application was observed after an average 13.4 s (range 7-19 ± 4.2 s).Echo intensity corresponding to maxi.mum vascularity was measured 30 s after application of contrast medium. Maximum average contrast medium uptake was 217.5% (range 118-466 ± 100.1% ). Conclusions. It is possible to quantify bowel wall vascularity accurately in patients with Crohn’ s disease using contrast-enhanced pulse inversion ultrasound (low-MI).
