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骨桥蛋白通过促血管新生调节心肌梗死后左室重构
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作者 赵学 钟才进 +2 位作者 吴宗贵 Mahipal singh krishna singh 《上海医学》 CAS CSCD 北大核心 2005年第4期301-303,共3页
目的观察骨桥蛋白(OPN)转基因小鼠(OPN -/- )心肌梗死后心肌血管新生能力及其与左室重构的关系.方法采用OPN -/- 小鼠体外心肌内皮细胞管结构形成、体内心肌Matrigel植入及心肌梗死3种模型,以野生型小鼠(WT)作为对照.结果体外培养的OPN ... 目的观察骨桥蛋白(OPN)转基因小鼠(OPN -/- )心肌梗死后心肌血管新生能力及其与左室重构的关系.方法采用OPN -/- 小鼠体外心肌内皮细胞管结构形成、体内心肌Matrigel植入及心肌梗死3种模型,以野生型小鼠(WT)作为对照.结果体外培养的OPN -/- 小鼠心肌血管内皮细胞在Matrigel的管结构生成显著减弱,可溶性OPN能明显改善OPN -/- 内皮细胞的管结构生成能力.在OPN -/- 小鼠心肌Matrigel植入模型,毛细血管样结构生成的体积明显降低.OPN -/- 小鼠心肌梗死后7和14 d,梗死区毛细血管密度和小动脉密度均明显降低.且在梗死后7~14 d,OPN -/- 小鼠小动脉的去血管化速率显著加快.OPN -/- 小鼠心肌梗死后,左室扩大及梗死区室壁变薄均较对照组显著.结论 OPN的促血管新生机制在心肌梗死后左室重构的调节中起重要作用. 展开更多
关键词 后左室重构 心肌梗死 促血管新生 Matrigel 调节 白通 血管新生能力 血管内皮细胞 毛细血管密度 血管新生机制 结构生成 小鼠心肌 转基因小鼠 骨桥蛋白 体外培养 生成能力 左室扩大 OPN 小动脉 梗死区 死后 野生型 可溶性
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Psychosurgery:A History from Prefrontal Lobotomy to Deep Brain Stimulation
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作者 Aisha Yousaf krishna singh +1 位作者 Victoria Tavernor Ashley Baldwin 《Journal of Geriatric Medicine》 2019年第3期1-8,共8页
Neurosurgical treatment for psychiatric disorders features a long and controversial history.This article explores a“spectrum of psychosurgery”,describing how old-fashioned and controversial prefrontal lobotomy gradu... Neurosurgical treatment for psychiatric disorders features a long and controversial history.This article explores a“spectrum of psychosurgery”,describing how old-fashioned and controversial prefrontal lobotomy gradually evolved into modern day,mainstream scientific deep brain stimulation(DBS).We focus on the rise,fall and possible re-emergence of psychosurgery as a therapeutic intervention today.We journey through historic indiscriminate use of prefrontal lobotomy,which evoked stern criticism from both public and professionals,through to the development of modern day DBS-performed for patients suffering from severe,treatment resistant symptoms of obsessive-compulsive disorder(OCD),epilepsy and movement disorders.We hope this article will provide a basis for understanding the availability of existing treatment options and potential future opportunities,whilst simultaneously challenging any public/professional preconceptions of psychosurgery,which may indirectly be obstructing patient care.Additionally,we carried out a qualitative survey displayed in WordCloud Format,capturing the intellection of 38 mental health professionals working for North West Boroughs NHS Healthcare Foundation Trust,on“psychosurgery”,“prefrontal lobotomy”and“DBS”,which may well reflect wider public opinion.In summary,the article provides a brief,yet comprehensive overview of the controversial history of psychosurgery,present-day practice,and future trends of neurosurgery for psychiatric disorders. 展开更多
关键词 PSYCHOSURGERY Prefrontal lobotomy Deep brain stimulation Obsessive compulsive disorder Tourette syndrome EPILEPSY Parkinson's Disease One flew over the cuckoo's nest
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