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Dopamine: an immune transmitter 被引量:9
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作者 Sarah Thomas Broome krystal louangaphay +3 位作者 Kevin AKeay Gian Marco Leggio Giuseppe Musumeci Alessandro Castorina 《Neural Regeneration Research》 SCIE CAS CSCD 2020年第12期2173-2185,共13页
The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesi... The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesis of neurodegenerative and psychiatric disorders, in particular Parkinson’s disease, which are associated with a subtle and chronic inflammatory response. A substantial body of evidence has demonstrated the non-neuronal expression of dopamine, its receptors and of the machinery that governs synthesis, secretion and storage of dopamine across several immune cell types. This review aims to summarize current knowledge on the role and expression of dopamine in immune cells. One of the goals is to decipher the complex mechanisms through which these cell types respond to dopamine, in order to address the impact this has on neurodegenerative and psychiatric pathologies such as Parkinson’s disease. A further aim is to illustrate the gaps in our understanding of the physiological roles of dopamine to encourage more targeted research focused on understanding the consequences of aberrant dopamine production on immune regulation. These highlights may prompt scientists in the field to consider alternative functions of this important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies. 展开更多
关键词 ASTROCYTE autoimmune disease DOPAMINE dopamine receptors D3R immune transmitter MICROGLIA multiple sclerosis NEUROINFLAMMATION Parkinson’s disease
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