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In vitro neuroprotective effects of ciliary neurotrophic factor on dorsal root ganglion neurons with glutamate-induced neurotoxicity 被引量:6
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作者 Shu-yun Wen Ai-min Li +4 位作者 kuan-qing mi Rui-zheng Wang Hao Li Hua-xiang Liu Yi Xing 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第10期1716-1723,共8页
Ciliary neurotrophic factor has neuroprotective effects mediated through signal transducer and Janus kinase(JAK) 2/activator of transcription 3(STAT3) and phosphatidylinositol 3-kinase(PI3 K)/Akt signaling pathw... Ciliary neurotrophic factor has neuroprotective effects mediated through signal transducer and Janus kinase(JAK) 2/activator of transcription 3(STAT3) and phosphatidylinositol 3-kinase(PI3 K)/Akt signaling pathways.Whether ciliary neurotrophic factor is neuroprotective for glutamate-induced excitotoxicity of dorsal root ganglion neurons is poorly understood.In the present study,the in vitro neuroprotective effects of ciliary neurotrophic factor against glutamate-induced excitotoxicity were determined in a primary culture of dorsal root ganglion neurons from Wistar rat embryos at embryonic day 15.Whether the JAK2/STAT3 and PI3 K/Akt signaling pathways were related to the protective effects of ciliary neurotrophic factor was also determined.Glutamate exposure inhibited neurite outgrowth,cell viability,and growth-associated protein 43 expression and promoted apoptotic neuronal cell death,all of which were reversed by the administration of exogenous ciliary neurotrophic factor.Additionally,preincubation with either JAK2 inhibitor AG490 or PI3 K inhibitor LY294002 blocked the neuroprotective effect of ciliary neurotrophic factor.These data indicate that the two pathways JAK2/STAT3 and PI3 K/Akt play major roles in mediating the in vitro neuroprotective effects of ciliary neurotrophic factor on dorsal root ganglion neurons with glutamate-induced neurotoxicity. 展开更多
关键词 nerve regeneration ciliary neurotrophic factor JAK2/STAT3 PI3K/Akt glutamate neuron excitotoxicity neuroprotection growth-associated protein 43 neurite outgrowth dorsal root ganglion neural regeneration
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