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Brilliant blue G attenuates lipopolysaccharide-mediated microglial activation and inflammation 被引量:1
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作者 kui lu Jue Wang +4 位作者 Bin Hu Xiaolei Shi Junyi Zhou Yamei Tang Ying Peng 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第7期599-608,共10页
Previous studies have confirmed that oxidized adenosine triphosphate, a P2X7 receptor antagonist, attenuates lipopolysaccharide-mediated microglial activation and inflammatory expression following neuronal damage in r... Previous studies have confirmed that oxidized adenosine triphosphate, a P2X7 receptor antagonist, attenuates lipopolysaccharide-mediated microglial activation and inflammatory expression following neuronal damage in rat brain. NaCI and temperature may affect the potency of oxidized adenosine triphosphate. Brilliant blue G is a derivative of a widely used food additive and has little toxicity. This study explored the effects of brilliant blue G, a selective P2X7 receptor antagonist, on microglial activation and inflammation. Results demonstrated that brilliant blue G inhibited the release of cydooxygenase-2 and interleukin-6 in BV2 cells. Immunofluorescence displayed that brilliant blue G could suppress lipopolysaccharide-induced microglial activation. This study used RNA interference to block P2X7 receptor expression and found that small interfering RNA also suppressed the release of cyclooxygenase-2 and interleukin-6 in BV2 cells. These results suggested that downregulation of the P2X7 receptor by brilliant blue G was involved in the inhibition of microglial activation and inflammation. 展开更多
关键词 neural regeneration neurodegenerative disease brilliant blue G P2X7 receptor LIPOPOLYSACCHARIDE microglia inflammatory cytokines RNA interference CYCLOOXYGENASE-2 interleukin-6 grants-supported paper photographs-containing paper NEUROREGENERATION
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Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria 被引量:13
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作者 Li Li Hong-Ping Tan +8 位作者 Cheng-Yong Liu Lin-Tao Yu Da-Nian Wei Zi-Chen Zhang kui lu Ke-Sen Zhao Marc Maegele Dao-Zhang Cai Zheng-Tao Gu 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第9期1573-1582,共10页
Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To inve... Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To investigate the protective effect of polydatin after traumatic brain injury,a rat brain injury model of lateral fluid percussion was established to mimic traumatic brain injury insults.Rat models were intraperitoneally injected with polydatin(30 mg/kg)or the SIRT1 activator SRT1720(20 mg/kg,as a positive control to polydatin).At 6 hours post-traumatic brain injury insults,western blot assay was used to detect the expression of SIRT1,endoplasmic reticulum stress related proteins and p38 phosphorylation in cerebral cortex on the injured side.Flow cytometry was used to analyze neuronal mitochondrial superoxide,mitochondrial membrane potential and mitochondrial permeability transition pore opened.Ultrastructural damage in neuronal mitochondria was measured by transmission electron microscopy.Our results showed that after treatment with polydatin,release of reactive oxygen species in neuronal mitochondria was markedly reduced;swelling of mitochondria was alleviated;mitochondrial membrane potential was maintained;mitochondrial permeability transition pore opened.Also endoplasmic reticulum stress related proteins were inhibited,including the activation of p-PERK,spliced XBP-1 and cleaved ATF6.SIRT1 expression and activity were increased;p38 phosphorylation and cleaved caspase-9/3 activation were inhibited.Neurological scores of treated rats were increased and the mortality was reduced compared with the rats only subjected to traumatic brain injury.These results indicated that polydatin protectrd rats from the consequences of traumatic brain injury and exerted a protective effect on neuronal mitochondria.The mechanisms may be linked to increased SIRT1 expression and activity,which inhibits the p38 phosphorylation-mediated mitochondrial apoptotic pathway.This study was approved by the Animal Care and Use Committee of the Southern Medical University,China(approval number:L2016113)on January 1,2016. 展开更多
关键词 nerve REGENERATION TRAUMATIC brain injury POLYDATIN MITOCHONDRIA endoplasmic reticulum stress SIRT1 reactive oxygen species p38 MITOCHONDRIAL membrane potential MITOCHONDRIAL permeability transition pore lateral fluid PERCUSSION neural REGENERATION
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Synthesis and Characterization of Boron Complex of Calix[4]arene
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作者 kui lu Yang Jie WU Zhi Xian ZHOU(Department of Chemistry, Zhengzhou University, 450052) 《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第2期99-100,共2页
A new boron complex of calix[4]arene was synthesized by the reaction of calix[4]arene with BMS; and the structure of the product was characterized by IR- (HNMR)-H-1. (CNMR)-C-13, (BNMR)-B-11 and MS spectra.
关键词 boron complex CALIX[4]ARENE SYNTHESIS CHARACTERIZATION
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A mix & act liposomes of phospholipase A2-phosphatidylserine for acute brain detoxification by blood‒brain barrier selective-opening
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作者 Zinan Zhang Wenbin Cao +8 位作者 Huanchun Xing Shuai Guo Lijuan Huang Lin Wang Xin Sui kui lu Yuan luo Yongan Wang Jun Yang 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2024年第4期1827-1844,共18页
In the treatment of central nervous system disease,the blood-brain barrier(BBB)is a major obstruction to drug delivery that must be overcome.In this study,we propose a brain-targeted delivery strat-egy based on select... In the treatment of central nervous system disease,the blood-brain barrier(BBB)is a major obstruction to drug delivery that must be overcome.In this study,we propose a brain-targeted delivery strat-egy based on selective opening of the BBB.This strategy allows some simple bare nanoparticles to enter the brain when mixed with special opening material;however,the BBB still maintains the ability to completely block molecules from passing through.Based on the screening of BBB opening and matrix delivery mate-rials,we determined that phospholipase A2-catalyzed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine li-posomes can efficiently carry drugs into the brain immediately.At an effective dose,this delivery system is safe,especially with its effect on the BBB being reversible.This mix&act delivery system has a simple structure and rapid preparation,making it a strong potential candidate for drug delivery across the BBB. 展开更多
关键词 Liposomes Phospholipase A2 PHOSPHOSERINE Blood-brainbarrier Selectively open Mix&act
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S-Trifluoroethyl Benzenesulfonothioate:A Bench-Stable Reagent for Electrophilic Trifluoroethylthiolation 被引量:1
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作者 Shuai Huang Ziheng Xi +3 位作者 kui lu Haifeng lu Chen-Ho Tung Zhenghu Xu 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2020年第12期1625-1628,共4页
of main observation and conclusion We report herein a practical approach for synthesis of an electrophilic trifluoroethylthiolation reagent PhSO2SCH2CF3(1)from easily available materials.The reaction proceeded through... of main observation and conclusion We report herein a practical approach for synthesis of an electrophilic trifluoroethylthiolation reagent PhSO2SCH2CF3(1)from easily available materials.The reaction proceeded through a protonation and nucleophilic substitution cascade of the in situ formed trifluorodiazoethane.This bench-stable reagent could easily be applied to introduce trifluoroethylthio group into small organic molecules. 展开更多
关键词 materials. REAGENT SUBSTITUTION
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