An efficient N–H and C(sp~3)-H functionalization of aryl ketones with benzylamines/amino acids was developed under mild conditions by virtue of anodic oxidation. A variety of functionalized 2,5-diaryloxazoles were ob...An efficient N–H and C(sp~3)-H functionalization of aryl ketones with benzylamines/amino acids was developed under mild conditions by virtue of anodic oxidation. A variety of functionalized 2,5-diaryloxazoles were obtained with good to excellent yields. Moreover, some important natural products can be prepared by this method. The reaction features a broad substrate scope, scalability, metal-free and chemical oxidant-free.展开更多
An efficient asymmetric alkenylation between 3-vinylindoles and isatin derivatives was developed under catalysis of a chiral copper complex.A series of optically active 3-alkenyl-3-substituted oxindoles were obtained ...An efficient asymmetric alkenylation between 3-vinylindoles and isatin derivatives was developed under catalysis of a chiral copper complex.A series of optically active 3-alkenyl-3-substituted oxindoles were obtained in excellent yields and stereoselectivities.The reaction mechanism was proposed and supported by DFT calculation.展开更多
A selective electrochemical oxidation was developed under mild condition.Various mono-carbonyl and multi-carbonyl compounds can be prepared from different aromatic hydrocarbons with moderate to excellent yield and sel...A selective electrochemical oxidation was developed under mild condition.Various mono-carbonyl and multi-carbonyl compounds can be prepared from different aromatic hydrocarbons with moderate to excellent yield and selectivity by virtue of this electrochemical oxidation.The produced carbonyl compounds can be further transformed intoα-ketoamides,homoallylic alcohols and oximes in a one-pot reaction.In particular,a series ofα-ketoamides were prepared in a one-pot continuous electrolysis.Mechanistic studies showed that 2,2,2-trifluoroethan-1-ol(TFE)can interact with catalyst species and generate the corresponding hydrogen-bonding complex to enhance the electrochemical oxidation performance.展开更多
基金the financial support from the National Natural Science Foundation of China (Nos.2177218522001241)+1 种基金the support from the Science and Technology Major Project of Anhui Province of China (No.201903a07020003)the Science and Technology Major Project of Fuyang of Anhui Province of China(No.FK20208018)。
文摘An efficient N–H and C(sp~3)-H functionalization of aryl ketones with benzylamines/amino acids was developed under mild conditions by virtue of anodic oxidation. A variety of functionalized 2,5-diaryloxazoles were obtained with good to excellent yields. Moreover, some important natural products can be prepared by this method. The reaction features a broad substrate scope, scalability, metal-free and chemical oxidant-free.
基金support from the National Natural Science Foundation of China(No.21772185)supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000).
文摘An efficient asymmetric alkenylation between 3-vinylindoles and isatin derivatives was developed under catalysis of a chiral copper complex.A series of optically active 3-alkenyl-3-substituted oxindoles were obtained in excellent yields and stereoselectivities.The reaction mechanism was proposed and supported by DFT calculation.
基金supported by the National Natural Science Foundation of China(21672200,21772185)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB20000000)。
文摘A selective electrochemical oxidation was developed under mild condition.Various mono-carbonyl and multi-carbonyl compounds can be prepared from different aromatic hydrocarbons with moderate to excellent yield and selectivity by virtue of this electrochemical oxidation.The produced carbonyl compounds can be further transformed intoα-ketoamides,homoallylic alcohols and oximes in a one-pot reaction.In particular,a series ofα-ketoamides were prepared in a one-pot continuous electrolysis.Mechanistic studies showed that 2,2,2-trifluoroethan-1-ol(TFE)can interact with catalyst species and generate the corresponding hydrogen-bonding complex to enhance the electrochemical oxidation performance.
