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Role of ABC transporters in cancer chemotherapy 被引量:10
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作者 Sun, Yue-Li Patel, Atish +1 位作者 kumar, priyank Chen, Zhe-Sheng 《Chinese Journal of Cancer》 SCIE CAS CSCD 2012年第2期51-57,共7页
Multidrug resistance(MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality.The major mechanism involved in conferring MDR is the overexpression of ATP-b... Multidrug resistance(MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality.The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette(ABC) transporters,which can increase efflux of drugs from cancer cells,thereby decreasing intracellular drug concentration.Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs.This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR. 展开更多
关键词 转运蛋白 ABC 化疗 癌症 多药耐药 药物浓度 过度表达 抗癌药物
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