When accounting the CO_2 emissions responsibility of the electricity sector at the provincial level in China,it is of great significance to consider the scope of both producers' and the consumers' responsibili...When accounting the CO_2 emissions responsibility of the electricity sector at the provincial level in China,it is of great significance to consider the scope of both producers' and the consumers' responsibility,since this will promote fairness in defining emission responsibility and enhance cooperation in emission reduction among provinces.This paper proposes a new method for calculating carbon emissions from the power sector at the provincial level based on the shared responsibility principle and taking into account interregional power exchange.This method can not only be used to account the emission responsibility shared by both the electricity production side and the consumption side,but it is also applicable for calculating the corresponding emission responsibility undertaken by those provinces with net electricity outflow and inflow.This method has been used to account for the carbon emissions responsibilities of the power sector at the provincial level in China since 2011.The empirical results indicate that compared with the production-based accounting method,the carbon emissions of major power-generation provinces in China calculated by the shared responsibility accounting method are reduced by at least 10%,but those of other power-consumption provinces are increased by 20% or more.Secondly,based on the principle of shared responsibility accounting,Inner Mongolia has the highest carbon emissions from the power sector while Hainan has the lowest.Thirdly,four provinces,including Inner Mongolia,Shanxi,Hubei and Anhui,have the highest carbon emissions from net electricity outflow- 14 million t in 2011,accounting for 74.42% of total carbon emissions from net electricity outflow in China.Six provinces,including Hebei,Beijing,Guangdong,Liaoning,Shandong,and Jiangsu,have the highest carbon emissions from net electricity inflow- 11 million t in 2011,accounting for 71.44% of total carbon emissions from net electricity inflow in China.Lastly,this paper has estimated the emission factors of electricity consumption at the provincial level,which can avoid repeated calculations when accounting the emission responsibility of power consumption terminals(e.g.construction,automobile manufacturing and other industries).In addition,these emission factors can also be used to account the emission responsibilities of provincial power grids.展开更多
Background:To explore the application effect of Acknowledge-Introduce-Duration-Explanation-Thank you(AIDET)communication mode in reducing anxiety and improving the care services satisfaction of the patients.Methods:Th...Background:To explore the application effect of Acknowledge-Introduce-Duration-Explanation-Thank you(AIDET)communication mode in reducing anxiety and improving the care services satisfaction of the patients.Methods:The 100 cases undergoing cataract daytime operation from February to July 2019 were divided into test group and control group.The test group conducted health education and nursing care for patients during admission,pre-operation,post-operation,and discharge according to the AIDET communication mode.And the control group was given health education and nursing care to the patients according to the traditional way of communication.Results:The difference of the socioeconomic information between these two groups showed no statistical significance.The care services satisfaction score in the test group was statistically higher than that in the control group(P<0.05).The Self-Rating Anxiety Scale(SAS)score in the test group was significantly lower than that in the control group(P<0.01).This result indicated that the patients suffered less anxiety with the AIDET mode of communication.Conclusions:The application of AIDET communication mode to the nursing service of cataract daytime operation can reduce the tension and anxiety of the patients from the treatment and improve their satisfaction to care services.展开更多
Objective: Hip arthroscopy technique application of diagnosis and treatment of suspected intra-articular infection cases after total hip arthroplasty. Methods: After femoral prosthesis side debridement processing thor...Objective: Hip arthroscopy technique application of diagnosis and treatment of suspected intra-articular infection cases after total hip arthroplasty. Methods: After femoral prosthesis side debridement processing thoroughly, we do skin preparation and draping again for exploring intra-articular using hip arthroscopy technique. Results: Though hip arthroscopy we can see a lot of scar hyperplasia and no obvious signs of infection. Conclusion: Minimally invasive techniques of hip arthroscopy can be applied to the detection of intra-articular infection after total hip arthroplasty.展开更多
Objective:To study and analyze the clinical efficacy of fixation of the elastic bandage of immobilization of knee-chest position and Pavlik harness fixation in the treatment of neonatal femoral shaft fractures.Methods...Objective:To study and analyze the clinical efficacy of fixation of the elastic bandage of immobilization of knee-chest position and Pavlik harness fixation in the treatment of neonatal femoral shaft fractures.Methods:A retrospective analysis was conducted from May 2010 to March 2017 with a total of 37 cases of femoral shaft fracture of the newborn.Among them,17 newborns with femur shaft fracture were treated using this fixation of the elastic bandage of immobilization of knee-chest position,and 20 newborns were treated utilizing Pavlik harness fixation.All patients were followed up for 24 months.It was compared between the two groups in length of hospitalization,hospitalization cost,the incidence of complications,fracture healing rate and post-operation angulation,rotation and shortening indexes.Results:Compared with the Pavlik harness fixation group,the hospitalization cost of knee-chest elastic bandage fixation group was lower(P<0.05),the difference was statistically significant.There is no significant difference between the two groups in terms of length of hospitalization,complications and fracture healing.The two groups of treatment methods compared in angle formation,rotation and shortness(P>0.05),with no statistical difference.Conclusions:Both knee-chest elastic bandage fixation and Pavlik harness fixation are effective methods for the treatment of neonatal femoral shaft fractures.But the former has lower cost and simpler operation,which is worthy of clinical application.展开更多
Objective:To investigate the effect of luteolin on the Epithelial-mesenchymal transition(EMT)of osteosarcoma cell line U2OS and its molecular mechanism by regulating phosphoinositide 3-kinase/protein kinase B/nuclear ...Objective:To investigate the effect of luteolin on the Epithelial-mesenchymal transition(EMT)of osteosarcoma cell line U2OS and its molecular mechanism by regulating phosphoinositide 3-kinase/protein kinase B/nuclear factor-kappa B(PI3K/AKT/NF-κB)signaling pathway.Methods:U2OS cells were treated in different concentrations(10,20 and 40μmol/L)of luteolin.MTT was used to detect the effect of luteolin on the proliferation of osteosarcoma U2OS cells.Transwell chamber assay was used to detect the influence of luteolin on migration of U2OS cells.qPCR was used to detect the influence of luteolin on the mRNA expression of Bax,Bcl-2 and Caspase-2 in U2OS cells.Western blot was used to observe the change of p-PI3K,p-AKT,p-IKK and NF-κB proteins.Immunofluorescence was used to detect the influence of luteolin on the protein expression of E-cadherin and vimentim.Results:Luteolin inhibited significantly the proliferation of U2OS cells(P<0.05)in a time-concentration-dependent manner.Luteolin inhibited significantly the migration of U2OS cells(P<0.05).After treatment with luteolin,the mRNA expression of Bax and Caspase-2 was increased significantly(P<0.05),but Bcl-2 was reduced significantly(P<0.05)in U2OS cells.The protein expression of p-PI3K,p-AKT,p-IKK,NF-κB,E-cadherin and vimentin was decreased significantly(P<0.05).Conclusions:Luteolin inhibits the proliferation,migration and EMT transformation of osteosarcoma U2OS cells,which may be related to the inhibition of PI3K/AKT/NF-κB signaling pathway.展开更多
Advanced composites are critical materials for the development of high-end equipment,as we say one generation of materials and one generation of equipment.Following materials such as aluminum,steel,and titanium,compos...Advanced composites are critical materials for the development of high-end equipment,as we say one generation of materials and one generation of equipment.Following materials such as aluminum,steel,and titanium,composite materials will become one of the four major materials in the field of aeronautics and astronautics.Usage of advanced composites is expected to exceed 50%in new commercial airplanes to significantly improve the level of lightweight.Thus,innovative devel-opment of high-end equipment in aerospace,rail traffic,biomedical and other fields also have an urgent demand for high-performance and multi-functional composites.展开更多
门控循环单元(gated recurrent unit, GRU)是一种有代表性的深度神经网络,它在众多序列学习任务中达到了国际领先的水平.然而,在门控循环单元的每个时间步之间,输入信息与隐含状态信息缺乏交互,这对更好地挖掘上下文语义信息带来了挑战...门控循环单元(gated recurrent unit, GRU)是一种有代表性的深度神经网络,它在众多序列学习任务中达到了国际领先的水平.然而,在门控循环单元的每个时间步之间,输入信息与隐含状态信息缺乏交互,这对更好地挖掘上下文语义信息带来了挑战.针对这个问题,本文提出了一个新颖的序列学习通用的语义特征提取模型:交互门控循环单元(interactive gated recurrent unit, InterGRU),可以让输入与隐含状态向量在各时间步间进行多轮充分的交互.并且,在到达时间估计(estimated time of arrival, ETA)这个有代表性、有挑战的时空序列预测任务上,本文提出了一套基于交互门控循环单元的深度学习框架(InterGRU-ETA).本文在来自滴滴出行平台真实场景下的海量数据集上充分地实验验证了InterGRU-ETA.结果表明,我们的框架在预测准确率上优于目前国际上最先进的方法.这反映了交互门控循环单元在捕获序列语义信息上的性能优势和广阔前景.展开更多
Background: Chronic kidney disease (CKD) is closely related to the cardiovascular events in vascular calcification (VC). However, little has known about the characteristics of kidney injury caused by VC. Fibrobla...Background: Chronic kidney disease (CKD) is closely related to the cardiovascular events in vascular calcification (VC). However, little has known about the characteristics of kidney injury caused by VC. Fibroblast growth factor 21 (FGF21 ) is an endocrine thctor, which takes part in various metabolic actions with the potential to alleviate metabolic disorder diseases, Even FGF21 has been regarded as a biomarker in CKD, the role of FGF21 in CKD remains unclear. Therefore, in this study, we evaluate the FGF21 on the kidney injury in VC rats. Methods: The male Sprague-Dawley rats were divided into three groups: ( 1 ) control group, (2) Vitamin D3 plus nicotine (VDN)-induced VC group, (3) FGF21-treated VDN group. After 4 weeks, the rats were killed and the blood was collected for serum creatinine, urea nitrogen, calcium, and phosphate measurement. Moreover, the renal tissues were homogenized for alkaline phosphatases (ALPs) activity and calcium content. The levels of FGF21 protein were measured by radioimmunoassay. The levels of β-Klotho and FGF receptor 1 (FGFR1) protein were measured by enzyme-linked immunosorbent assay (EL1SA). The structural damage and calcifications in aortas were stained by Alizarin-red S. Moreover, the structure of kidney was observed by hematoxylin and eosin staining. Results: The renal lhnction impairment caused by VDN modeling was ameliorated by FGF21 treatment, inhibited the elevated serum creatinine and urea level by 20.5% (34.750 ± 4.334 pmol/L vs. 27.630± 2.387pamol/L) and 4.0% (7.038 ± 0.590 mmol/L vs. 6.763 ±0.374 mmol/L; P 〈 0.01 ), respectively, together with the structural damages of glomerular atrophy and renal interstitial fibrosis. FGF21 treatment downregulated the ALP activity, calcium content in the kidney of VC rats by 42.1% (P 〈 0.01 ) and 11.7% (P 〈 0.05) as well as ameliorated the aortic injury and calcification as compared with VDN treatment alone group, indicating an ameliorative effect on VC. EL1SA assays showed that the expression of [3-Klotho, a component of FGF21 receptor system was increased in VDN-treated VC rats by 37.4% (6.588 ± 0.957 pg/mg vs. 9.054 ± 0.963 pg/mg; P 〈 0.01), indicating an FGF2 l-resistant state. Moreover, FGF21 treatment downregulated the level of β-Klotho in renal tissue by 16.7% (9.054 ± 0.963 pg/mg vs. 7.544± 1.362 pg/mg, P 〈 0.05). However, the level of FGFR1, the receptor of FGF21, kept unchanged under VDN and VDN plus FGF21 administration (0.191 ± 0.0376 rig/rag vs. 0.189 ± 0.032 ng/mg rs. 0.181± 0.034 mg/mg; P 〉 0.05). Conclusions: In the present study, FGF21 was observed to ameliorate the kidney injury in VDN-induced VC rats. FGF21 might be a potential therapeutic factor in CKD by cutting offthe vicious circle between VC and kidney injury.展开更多
Thermal management of textiles requires local microclimate control over heat and wet dissipation to create a comfortable thermal-wet environment at the interface of the human body and clothing.Herein,we design a fabri...Thermal management of textiles requires local microclimate control over heat and wet dissipation to create a comfortable thermal-wet environment at the interface of the human body and clothing.Herein,we design a fabric capable of both sweat-and cooling-management using a knitted fabric featuring a bilayer structure consisting of hydrophobic polyethylene terephthalate and hydrophilic cellulose fibers to simultaneously achieve high infrared(IR)transmittance and good thermal-wet comfort.The IR transmission of this cooling textile increased by~twofold in the dry state and~eightfold in the wet state compared to conventional cotton fabric.When the porosity changes from 10 to 47%with the comparison of conventional cotton fabric and our cooling textile,the heat flux is increased from 74.4 to 152.3 W/cm^(2).The cooling effect of the cooling fabric is 105%greater than that of commercial cotton fabric,which displays a better thermal management capacity for personal cooling.This bilayer design controls fast moisture transfer from inside out and provides thermal management,demonstrating high impact not only for garments,but also for other systems requiring heat regulation,such as buildings,which could mitigate energy demand and ultimately contribute to the relief of global energy and climate issues.展开更多
Airborne laser scanning (ALS) is a technique used to obtain Digital Surface Models (DSM) and Digital Terrain Models (DTM) efficiently, and filtering is the key procedure used to derive DTM from point clouds. Gen...Airborne laser scanning (ALS) is a technique used to obtain Digital Surface Models (DSM) and Digital Terrain Models (DTM) efficiently, and filtering is the key procedure used to derive DTM from point clouds. Generating seed points is an initial step for most filtering algorithms, whereas existing algorithms usually define a regular window size to generate seed points. This may lead to an inadequate density of seed points, and further introduce error type I, especially in steep terrain and forested areas. In this study, we propose the use of object- based analysis to derive surface complexity information from ALS datasets, which can then be used to improve seed point generation. We assume that an area is complex if it is composed of many small objects, with no buildings within the area. Using these assumptions, we propose and implement a new segmentation algorithm based on a grid index, which we call the Edge and Slope Restricted Region Growing (ESRGG) algorithm. Surface complexity information is obtained by statistical analysis of the number of objects derived by segmentation in each area. Then, for complex areas, a smaller window size is defined to generate seed points. Experimental results show that the proposed algorithm could greatly improve the filtering results in complex areas, especially in steep terrain and forested areas.展开更多
基金supported by Philosophy and Social Sciences Key Projects of the Ministry of Education,"China's Carbon Emissions Trading System under the Low Carbon Economy"[Grant No.10JZD0018]Program for New Century Excellent Talents of the Ministry of Education[Grant No.NCET-10-0646]+2 种基金National Social Science Fund Project,"Path to Green Economy:China's Carbon Trading Mechanism"[Grant No.12&ZD059]Youth Science Fund Project of National Natural Science Foundation,"Impact of International Trade on China's Carbon Efficiency and Related Policy Research"[Grant No.71303176]Humanities and Social Sciences Youth Fund Project of the Ministry of Education,"Impact of International Trade on China's Carbon Efficiency and Related Policy Research"[Grant No.13YJC790073]
文摘When accounting the CO_2 emissions responsibility of the electricity sector at the provincial level in China,it is of great significance to consider the scope of both producers' and the consumers' responsibility,since this will promote fairness in defining emission responsibility and enhance cooperation in emission reduction among provinces.This paper proposes a new method for calculating carbon emissions from the power sector at the provincial level based on the shared responsibility principle and taking into account interregional power exchange.This method can not only be used to account the emission responsibility shared by both the electricity production side and the consumption side,but it is also applicable for calculating the corresponding emission responsibility undertaken by those provinces with net electricity outflow and inflow.This method has been used to account for the carbon emissions responsibilities of the power sector at the provincial level in China since 2011.The empirical results indicate that compared with the production-based accounting method,the carbon emissions of major power-generation provinces in China calculated by the shared responsibility accounting method are reduced by at least 10%,but those of other power-consumption provinces are increased by 20% or more.Secondly,based on the principle of shared responsibility accounting,Inner Mongolia has the highest carbon emissions from the power sector while Hainan has the lowest.Thirdly,four provinces,including Inner Mongolia,Shanxi,Hubei and Anhui,have the highest carbon emissions from net electricity outflow- 14 million t in 2011,accounting for 74.42% of total carbon emissions from net electricity outflow in China.Six provinces,including Hebei,Beijing,Guangdong,Liaoning,Shandong,and Jiangsu,have the highest carbon emissions from net electricity inflow- 11 million t in 2011,accounting for 71.44% of total carbon emissions from net electricity inflow in China.Lastly,this paper has estimated the emission factors of electricity consumption at the provincial level,which can avoid repeated calculations when accounting the emission responsibility of power consumption terminals(e.g.construction,automobile manufacturing and other industries).In addition,these emission factors can also be used to account the emission responsibilities of provincial power grids.
文摘Background:To explore the application effect of Acknowledge-Introduce-Duration-Explanation-Thank you(AIDET)communication mode in reducing anxiety and improving the care services satisfaction of the patients.Methods:The 100 cases undergoing cataract daytime operation from February to July 2019 were divided into test group and control group.The test group conducted health education and nursing care for patients during admission,pre-operation,post-operation,and discharge according to the AIDET communication mode.And the control group was given health education and nursing care to the patients according to the traditional way of communication.Results:The difference of the socioeconomic information between these two groups showed no statistical significance.The care services satisfaction score in the test group was statistically higher than that in the control group(P<0.05).The Self-Rating Anxiety Scale(SAS)score in the test group was significantly lower than that in the control group(P<0.01).This result indicated that the patients suffered less anxiety with the AIDET mode of communication.Conclusions:The application of AIDET communication mode to the nursing service of cataract daytime operation can reduce the tension and anxiety of the patients from the treatment and improve their satisfaction to care services.
文摘Objective: Hip arthroscopy technique application of diagnosis and treatment of suspected intra-articular infection cases after total hip arthroplasty. Methods: After femoral prosthesis side debridement processing thoroughly, we do skin preparation and draping again for exploring intra-articular using hip arthroscopy technique. Results: Though hip arthroscopy we can see a lot of scar hyperplasia and no obvious signs of infection. Conclusion: Minimally invasive techniques of hip arthroscopy can be applied to the detection of intra-articular infection after total hip arthroplasty.
基金It is supported by Natural Science Foundation in Hainan Province(809046).
文摘Objective:To study and analyze the clinical efficacy of fixation of the elastic bandage of immobilization of knee-chest position and Pavlik harness fixation in the treatment of neonatal femoral shaft fractures.Methods:A retrospective analysis was conducted from May 2010 to March 2017 with a total of 37 cases of femoral shaft fracture of the newborn.Among them,17 newborns with femur shaft fracture were treated using this fixation of the elastic bandage of immobilization of knee-chest position,and 20 newborns were treated utilizing Pavlik harness fixation.All patients were followed up for 24 months.It was compared between the two groups in length of hospitalization,hospitalization cost,the incidence of complications,fracture healing rate and post-operation angulation,rotation and shortening indexes.Results:Compared with the Pavlik harness fixation group,the hospitalization cost of knee-chest elastic bandage fixation group was lower(P<0.05),the difference was statistically significant.There is no significant difference between the two groups in terms of length of hospitalization,complications and fracture healing.The two groups of treatment methods compared in angle formation,rotation and shortness(P>0.05),with no statistical difference.Conclusions:Both knee-chest elastic bandage fixation and Pavlik harness fixation are effective methods for the treatment of neonatal femoral shaft fractures.But the former has lower cost and simpler operation,which is worthy of clinical application.
基金Natural Science Foundation in Hainan Province(No.814357).
文摘Objective:To investigate the effect of luteolin on the Epithelial-mesenchymal transition(EMT)of osteosarcoma cell line U2OS and its molecular mechanism by regulating phosphoinositide 3-kinase/protein kinase B/nuclear factor-kappa B(PI3K/AKT/NF-κB)signaling pathway.Methods:U2OS cells were treated in different concentrations(10,20 and 40μmol/L)of luteolin.MTT was used to detect the effect of luteolin on the proliferation of osteosarcoma U2OS cells.Transwell chamber assay was used to detect the influence of luteolin on migration of U2OS cells.qPCR was used to detect the influence of luteolin on the mRNA expression of Bax,Bcl-2 and Caspase-2 in U2OS cells.Western blot was used to observe the change of p-PI3K,p-AKT,p-IKK and NF-κB proteins.Immunofluorescence was used to detect the influence of luteolin on the protein expression of E-cadherin and vimentim.Results:Luteolin inhibited significantly the proliferation of U2OS cells(P<0.05)in a time-concentration-dependent manner.Luteolin inhibited significantly the migration of U2OS cells(P<0.05).After treatment with luteolin,the mRNA expression of Bax and Caspase-2 was increased significantly(P<0.05),but Bcl-2 was reduced significantly(P<0.05)in U2OS cells.The protein expression of p-PI3K,p-AKT,p-IKK,NF-κB,E-cadherin and vimentin was decreased significantly(P<0.05).Conclusions:Luteolin inhibits the proliferation,migration and EMT transformation of osteosarcoma U2OS cells,which may be related to the inhibition of PI3K/AKT/NF-κB signaling pathway.
文摘Advanced composites are critical materials for the development of high-end equipment,as we say one generation of materials and one generation of equipment.Following materials such as aluminum,steel,and titanium,composite materials will become one of the four major materials in the field of aeronautics and astronautics.Usage of advanced composites is expected to exceed 50%in new commercial airplanes to significantly improve the level of lightweight.Thus,innovative devel-opment of high-end equipment in aerospace,rail traffic,biomedical and other fields also have an urgent demand for high-performance and multi-functional composites.
文摘门控循环单元(gated recurrent unit, GRU)是一种有代表性的深度神经网络,它在众多序列学习任务中达到了国际领先的水平.然而,在门控循环单元的每个时间步之间,输入信息与隐含状态信息缺乏交互,这对更好地挖掘上下文语义信息带来了挑战.针对这个问题,本文提出了一个新颖的序列学习通用的语义特征提取模型:交互门控循环单元(interactive gated recurrent unit, InterGRU),可以让输入与隐含状态向量在各时间步间进行多轮充分的交互.并且,在到达时间估计(estimated time of arrival, ETA)这个有代表性、有挑战的时空序列预测任务上,本文提出了一套基于交互门控循环单元的深度学习框架(InterGRU-ETA).本文在来自滴滴出行平台真实场景下的海量数据集上充分地实验验证了InterGRU-ETA.结果表明,我们的框架在预测准确率上优于目前国际上最先进的方法.这反映了交互门控循环单元在捕获序列语义信息上的性能优势和广阔前景.
基金This study was funded by grants from National Natural Science Fund of China (No. 81570388), Beijing Natural Science Foundation (No. 7142048), and the Major State Basic Research Development Program of China (973 Program, No. 2015CB554404).
文摘Background: Chronic kidney disease (CKD) is closely related to the cardiovascular events in vascular calcification (VC). However, little has known about the characteristics of kidney injury caused by VC. Fibroblast growth factor 21 (FGF21 ) is an endocrine thctor, which takes part in various metabolic actions with the potential to alleviate metabolic disorder diseases, Even FGF21 has been regarded as a biomarker in CKD, the role of FGF21 in CKD remains unclear. Therefore, in this study, we evaluate the FGF21 on the kidney injury in VC rats. Methods: The male Sprague-Dawley rats were divided into three groups: ( 1 ) control group, (2) Vitamin D3 plus nicotine (VDN)-induced VC group, (3) FGF21-treated VDN group. After 4 weeks, the rats were killed and the blood was collected for serum creatinine, urea nitrogen, calcium, and phosphate measurement. Moreover, the renal tissues were homogenized for alkaline phosphatases (ALPs) activity and calcium content. The levels of FGF21 protein were measured by radioimmunoassay. The levels of β-Klotho and FGF receptor 1 (FGFR1) protein were measured by enzyme-linked immunosorbent assay (EL1SA). The structural damage and calcifications in aortas were stained by Alizarin-red S. Moreover, the structure of kidney was observed by hematoxylin and eosin staining. Results: The renal lhnction impairment caused by VDN modeling was ameliorated by FGF21 treatment, inhibited the elevated serum creatinine and urea level by 20.5% (34.750 ± 4.334 pmol/L vs. 27.630± 2.387pamol/L) and 4.0% (7.038 ± 0.590 mmol/L vs. 6.763 ±0.374 mmol/L; P 〈 0.01 ), respectively, together with the structural damages of glomerular atrophy and renal interstitial fibrosis. FGF21 treatment downregulated the ALP activity, calcium content in the kidney of VC rats by 42.1% (P 〈 0.01 ) and 11.7% (P 〈 0.05) as well as ameliorated the aortic injury and calcification as compared with VDN treatment alone group, indicating an ameliorative effect on VC. EL1SA assays showed that the expression of [3-Klotho, a component of FGF21 receptor system was increased in VDN-treated VC rats by 37.4% (6.588 ± 0.957 pg/mg vs. 9.054 ± 0.963 pg/mg; P 〈 0.01), indicating an FGF2 l-resistant state. Moreover, FGF21 treatment downregulated the level of β-Klotho in renal tissue by 16.7% (9.054 ± 0.963 pg/mg vs. 7.544± 1.362 pg/mg, P 〈 0.05). However, the level of FGFR1, the receptor of FGF21, kept unchanged under VDN and VDN plus FGF21 administration (0.191 ± 0.0376 rig/rag vs. 0.189 ± 0.032 ng/mg rs. 0.181± 0.034 mg/mg; P 〉 0.05). Conclusions: In the present study, FGF21 was observed to ameliorate the kidney injury in VDN-induced VC rats. FGF21 might be a potential therapeutic factor in CKD by cutting offthe vicious circle between VC and kidney injury.
基金This project was made possible by financial support from the Delivering Efficient Local Thermal Amenities(DELTA)Program of the Advanced Research Projects Agency-Energy(ARPA-E),U.S.Department of Energy.
文摘Thermal management of textiles requires local microclimate control over heat and wet dissipation to create a comfortable thermal-wet environment at the interface of the human body and clothing.Herein,we design a fabric capable of both sweat-and cooling-management using a knitted fabric featuring a bilayer structure consisting of hydrophobic polyethylene terephthalate and hydrophilic cellulose fibers to simultaneously achieve high infrared(IR)transmittance and good thermal-wet comfort.The IR transmission of this cooling textile increased by~twofold in the dry state and~eightfold in the wet state compared to conventional cotton fabric.When the porosity changes from 10 to 47%with the comparison of conventional cotton fabric and our cooling textile,the heat flux is increased from 74.4 to 152.3 W/cm^(2).The cooling effect of the cooling fabric is 105%greater than that of commercial cotton fabric,which displays a better thermal management capacity for personal cooling.This bilayer design controls fast moisture transfer from inside out and provides thermal management,demonstrating high impact not only for garments,but also for other systems requiring heat regulation,such as buildings,which could mitigate energy demand and ultimately contribute to the relief of global energy and climate issues.
基金Acknowledgements The authors would like m thank the anonymous reviewers for providing comments to improve the quality of this paper, and iSPACE of Research Studios Austria FG (RSA) (http://ispace.researchstudio. at/) for providing the ALS datasets. The study described in this paper is funded by the National Natural Science Foundation of China (Grant No. 41301493), the High Resolution Earth Observation Science Foundation of China (GFZX04060103-5-17), and Special Fund for Surveying and Mapping Scientific Research in the Public Interest (201412007).
文摘Airborne laser scanning (ALS) is a technique used to obtain Digital Surface Models (DSM) and Digital Terrain Models (DTM) efficiently, and filtering is the key procedure used to derive DTM from point clouds. Generating seed points is an initial step for most filtering algorithms, whereas existing algorithms usually define a regular window size to generate seed points. This may lead to an inadequate density of seed points, and further introduce error type I, especially in steep terrain and forested areas. In this study, we propose the use of object- based analysis to derive surface complexity information from ALS datasets, which can then be used to improve seed point generation. We assume that an area is complex if it is composed of many small objects, with no buildings within the area. Using these assumptions, we propose and implement a new segmentation algorithm based on a grid index, which we call the Edge and Slope Restricted Region Growing (ESRGG) algorithm. Surface complexity information is obtained by statistical analysis of the number of objects derived by segmentation in each area. Then, for complex areas, a smaller window size is defined to generate seed points. Experimental results show that the proposed algorithm could greatly improve the filtering results in complex areas, especially in steep terrain and forested areas.